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Sökning: onr:"swepub:oai:DiVA.org:umu-203194" > Genetically Determi...

Genetically Determined Reproductive Aging and Coronary Heart Disease : A Bidirectional 2-sample Mendelian Randomization

Dam, Veerle (författare)
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands; Netherlands Heart Institute, Utrecht, Netherlands,Interuniversity Cardiology Institute of the Netherlands
Onland-Moret, N. Charlotte (författare)
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
Burgess, Stephen (författare)
MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Homerton College, Cambridge, United Kingdom
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Chirlaque, Maria-Dolores (författare)
Department of Epidemiology, Regional Health Authority, IMIB-Arrixaca, Murcia University, Murcia, Spain
Peters, Sanne A. E (författare)
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands; The George Institute for Global Health, Imperial College London, London, United Kingdom
Schuit, Ewoud (författare)
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
Tikk, Kaja (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany; German Cancer Consortium, DKFZ, Heidelberg, Germany
Weiderpass, Elisabete (författare)
International Agency for Research on Cancer, World Health Organization, Lyon, France
Oliver-Williams, Clare (författare)
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Homerton College, Cambridge, United Kingdom
Wood, Angela M (författare)
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Tjønneland, Anne (författare)
Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Dahm, Christina C (författare)
Department of Public Health, Aarhus University, Aarhus, Denmark
Overvad, Kim (författare)
Department of Public Health, Aarhus University, Aarhus, Denmark; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark
Boutron-Ruault, Marie-Christine (författare)
INSERM, Centre for Research in Epidemiology and Population Health, U1018, Nutrition, Hormones, and Women's Health Team, Institut Gustave Roussy, Villejuif, France
Schulze, Matthias B (författare)
Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
Trichopoulou, Antonia (författare)
Hellenic Health Foundation, Athens, Greece; WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Ferrari, Pietro (författare)
International Agency for Research on Cancer, World Health Organization, Lyon, France
Masala, Giovanna (författare)
Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy
Krogh, Vittorio (författare)
Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
Tumino, Rosario (författare)
Cancer Registry and Histopathology Department, "Civic - M.P. Arezzo" hospital, ASP Ragusa, Ragusa, Italy
Matullo, Giuseppe (författare)
Department of Medical Sciences, University of Torino, Torino, Italy; Italian Institute for Genomic Medicine–IIGM/HuGeF, Torino, Italy
Panico, Salvatore (författare)
Dipartimento di medicina clinica e chirurgia, Federico II University, Naples, Italy
Boer, Jolanda M. A (författare)
National Institute for Public Health and the Environment, Bilthoven, Netherlands
Verschuren, W. M. Monique (författare)
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands; National Institute for Public Health and the Environment, Bilthoven, Netherlands
Waaseth, Marit (författare)
Department of Pharmacy, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromsø, Norway
PCrossed D sign©rez, Maria JosCrossed D sign© Sánchez (författare)
Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA, Universidad de Granada, Granada, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Amiano, Pilar (författare)
CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Public Health Division of Gipuzkoa, Biodonostia Research Institute, San Sebastian, Spain
Imaz, Liher (författare)
CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Public Health Division of Gipuzkoa, Biodonostia Research Institute, San Sebastian, Spain
Moreno-Iribas, Conchi (författare)
Instituto de Salud Pública de Navarra, IdiSNA, Navarre Institute for Health Research, REDISSEC, Pamplona, Spain
Melander, O. (författare)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Harlid, Sophia, 1978- (författare)
Umeå universitet,Onkologi
Nordendahl, Maria (författare)
Umeå universitet,Onkologi,Allmänmedicin
Wennberg, Patrik, 1972- (författare)
Umeå universitet,Allmänmedicin
Key, Timothy J (författare)
Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Riboli, Elio (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Santiuste, Carmen (författare)
CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Authority, IMIB-Arrixaca, Murcia, Spain
Kaaks, Rudolf (författare)
Division of Cancer Epidemiology, DKFZ, Foundation under Public Law, Heidelberg, Germany
Katzke, Verena (författare)
Division of Cancer Epidemiology, DKFZ, Foundation under Public Law, Heidelberg, Germany
Langenberg, Claudia (författare)
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
Wareham, Nicholas J (författare)
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
Schunkert, Heribert (författare)
Deutsches Herzzentrum München, Technische Universität München, Munich, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany
Erdmann, Jeanette (författare)
Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany
Willenborg, Christina (författare)
Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany
Hengstenberg, Christian (författare)
Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria
Kleber, Marcus E (författare)
Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Delgado, Graciela (författare)
Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
März, Winfried (författare)
Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
Kanoni, Stavroula (författare)
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
Dedoussis, George (författare)
Department of Nutrition-Dietetics/Harokopio University, Athens, Greece
Deloukas, Panos (författare)
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; Centre for Genomic Health, Queen Mary University of London, London, United Kingdom; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia
Nikpay, Majid (författare)
Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, ON, Ottawa, Canada
Mcpherson, Ruth (författare)
Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, ON, Ottawa, Canada
Scholz, Markus (författare)
Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
Teren, Andrej (författare)
LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Heart Center Leipzig, Leipzig, Germany
Butterworth, Adam S (författare)
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Van Der Schouw, Yvonne T (författare)
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
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 (creator_code:org_t)
2022-03-20
2022
Engelska.
Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 107:7, s. E2952-E2961
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Accelerated reproductive aging, in women indicated by early natural menopause, is associated with increased coronary heart disease (CHD) risk in observational studies. Conversely, an adverse CHD risk profile has been suggested to accelerate menopause. Objectives: To study the direction and evidence for causality of the relationship between reproductive aging and (non-)fatal CHD and CHD risk factors in a bidirectional Mendelian randomization (MR) approach, using age at natural menopause (ANM) genetic variants as a measure for genetically determined reproductive aging in women. We also studied the association of these variants with CHD risk (factors) in men. Design: Two-sample MR, using both cohort data as well as summary statistics, with 4 methods: simple and weighted median-based, standard inverse-variance weighted (IVW) regression, and MR-Egger regression. Participants: Data from EPIC-CVD and summary statistics from UK Biobank and publicly available genome-wide association studies were pooled for the different analyses. Main Outcome Measures: CHD, CHD risk factors, and ANM. Results: Across different methods of MR, no association was found between genetically determined reproductive aging and CHD risk in women (relative risk estimateIVW = 0.99; 95% confidence interval (CI), 0.97-1.01), or any of the CHD risk factors. Similarly, no associations were found in men. Neither did the reversed analyses show evidence for an association between CHD (risk factors) and reproductive aging. Conclusion: Genetically determined reproductive aging is not causally associated with CHD risk (factors) in women, nor were the genetic variants associated in men. We found no evidence for a reverse association in a combined sample of women and men.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

coronary heart disease
Mendelian Randomization
reproductive aging
risk factors
coronary heart disease
Mendelian Randomization
reproductive aging
risk factors
aging
coronary artery disease
female
genetics
genome-wide association study
human
male
Mendelian randomization analysis
procedures
single nucleotide polymorphism
Aging
Coronary Disease
Female
Genome-Wide Association Study
Humans
Male
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

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