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Is high vitamin B12...
Is high vitamin B12 status a cause of lung cancer?
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- Fanidi, Anouar (author)
- International Agency for Research on Cancer, World Health Organization,University of Cambridge
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Carreras-Torres, Robert (author)
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Larose, Tricia L. (author)
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show more...
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Yuan, Jian-Min (author)
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Stevens, Victoria L. (author)
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Weinstein, Stephanie J. (author)
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Albanes, Demetrius (author)
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Prentice, Ross (author)
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Pettinger, Mary (author)
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Cai, Qiuyin (author)
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Blot, William J. (author)
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Arslan, Alan A. (author)
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Zeleniuch-Jacquotte, Anne (author)
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McCullough, Marjorie L. (author)
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Le Marchand, Loic (author)
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Wilkens, Lynne R. (author)
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Haiman, Christopher A. (author)
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Zhang, Xuehong (author)
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Stampfer, Meir J. (author)
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Smith-Warner, Stephanie A. (author)
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Giovannucci, Edward (author)
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Giles, Graham G. (author)
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Hodge, Allison M. (author)
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Severi, Gianluca (author)
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- Johansson, Mikael (author)
- Umeå universitet,Onkologi
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- Grankvist, Kjell (author)
- Umeå universitet,Klinisk kemi
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Langhammer, Arnulf (author)
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Brumpton, Ben M. (author)
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Wang, Renwei (author)
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Gao, Yu-Tang (author)
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- Ericson, Ulrika (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Bojesen, Stig E. (author)
- Lund University
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Arnold, Susanne M. (author)
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Koh, Woon-Puay (author)
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Shu, Xiao-Ou (author)
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Xiang, Yong-Bing (author)
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Li, Honglan (author)
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Zheng, Wei (author)
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Lan, Qing (author)
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Visvanathan, Kala (author)
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Hoffman-Bolton, Judith (author)
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Ueland, Per M. (author)
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Midttun, Oivind (author)
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Caporaso, Neil E. (author)
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Purdue, Mark (author)
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Freedman, Neal D. (author)
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Buring, Julie E. (author)
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Lee, I-Min (author)
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Sesso, Howard D. (author)
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Gaziano, J. Michael (author)
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital
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Relton, Caroline L. (author)
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Hung, Rayjean J. (author)
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Amos, Chris, I (author)
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Johansson, Mattias (author)
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- Brennan, Paul (author)
- International Agency for Research on Cancer, World Health Organization
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(creator_code:org_t)
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- 2019-01-15
- 2019
- English.
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In: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 145:6, s. 1499-1503
- Related links:
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https://onlinelibrar...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Vitamin B supplementation can have side effects for human health, including cancer risk. We aimed to elucidate the role of vitamin B12 in lung cancer etiology via direct measurements of pre‐diagnostic circulating vitamin B12 concentrations in a nested case–control study, complemented with a Mendelian randomization (MR) approach in an independent case–control sample. We used pre‐diagnostic biomarker data from 5183 case–control pairs nested within 20 prospective cohorts, and genetic data from 29,266 cases and 56,450 controls. Exposures included directly measured circulating vitamin B12 in pre‐diagnostic blood samples from the nested case–control study, and 8 single nucleotide polymorphisms associated with vitamin B12 concentrations in the MR study. Our main outcome of interest was increased risk for lung cancer, overall and by histological subtype, per increase in circulating vitamin B12 concentrations. We found circulating vitamin B12 to be positively associated with overall lung cancer risk in a dose response fashion (odds ratio for a doubling in B12 [ORlog2B12] = 1.15, 95% confidence interval (95%CI) = 1.06–1.25). The MR analysis based on 8 genetic variants also indicated that genetically determined higher vitamin B12 concentrations were positively associated with overall lung cancer risk (OR per 150 pmol/L standard deviation increase in B12 [ORSD] = 1.08, 95%CI = 1.00–1.16). Considering the consistency of these two independent and complementary analyses, these findings support the hypothesis that high vitamin B12 status increases the risk of lung cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Fanidi, Anouar
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Carreras-Torres, ...
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Larose, Tricia L ...
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Yuan, Jian-Min
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Stevens, Victori ...
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Weinstein, Steph ...
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show more...
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Albanes, Demetri ...
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Prentice, Ross
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Pettinger, Mary
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Cai, Qiuyin
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Blot, William J.
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Arslan, Alan A.
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Zeleniuch-Jacquo ...
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McCullough, Marj ...
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Le Marchand, Loi ...
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Wilkens, Lynne R ...
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Haiman, Christop ...
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Zhang, Xuehong
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Stampfer, Meir J ...
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Smith-Warner, St ...
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Giovannucci, Edw ...
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Giles, Graham G.
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Hodge, Allison M ...
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Severi, Gianluca
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Johansson, Mikae ...
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Grankvist, Kjell
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Langhammer, Arnu ...
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Brumpton, Ben M.
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Wang, Renwei
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Gao, Yu-Tang
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Ericson, Ulrika
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Bojesen, Stig E.
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Arnold, Susanne ...
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Koh, Woon-Puay
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Shu, Xiao-Ou
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Xiang, Yong-Bing
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Li, Honglan
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Zheng, Wei
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Lan, Qing
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Visvanathan, Kal ...
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Hoffman-Bolton, ...
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Ueland, Per M.
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Midttun, Oivind
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Caporaso, Neil E ...
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Purdue, Mark
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Freedman, Neal D ...
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Buring, Julie E.
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Lee, I-Min
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Sesso, Howard D.
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Gaziano, J. Mich ...
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Manjer, Jonas
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Relton, Caroline ...
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Hung, Rayjean J.
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Amos, Chris, I
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Johansson, Matti ...
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Brennan, Paul
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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Umeå University
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Lund University