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Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci.

Tragante, Vinicius (author)
Barnes, Michael R (author)
Ganesh, Santhi K (author)
show more...
Lanktree, Matthew B (author)
Guo, Wei (author)
Franceschini, Nora (author)
Smith, Erin N (author)
Johnson, Toby (author)
Holmes, Michael V (author)
Padmanabhan, Sandosh (author)
Karczewski, Konrad J (author)
Almoguera, Berta (author)
Barnard, John (author)
Baumert, Jens (author)
Chang, Yen-Pei Christy (author)
Elbers, Clara C (author)
Farrall, Martin (author)
Fischer, Mary E (author)
Gaunt, Tom R (author)
Gho, Johannes M I H (author)
Gieger, Christian (author)
Goel, Anuj (author)
Gong, Yan (author)
Isaacs, Aaron (author)
Kleber, Marcus E (author)
Leach, Irene Mateo (author)
McDonough, Caitrin W (author)
Meijs, Matthijs F L (author)
Melander, Olle (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Nelson, Christopher P (author)
Nolte, Ilja M (author)
Pankratz, Nathan (author)
Price, Tom S (author)
Shaffer, Jonathan (author)
Shah, Sonia (author)
Tomaszewski, Maciej (author)
van der Most, Peter J (author)
Van Iperen, Erik P A (author)
Vonk, Judith M (author)
Witkowska, Kate (author)
Wong, Caroline O L (author)
Zhang, Li (author)
Beitelshees, Amber L (author)
Berenson, Gerald S (author)
Bhatt, Deepak L (author)
Brown, Morris (author)
Burt, Amber (author)
Cooper-Dehoff, Rhonda M (author)
Connell, John M (author)
Cruickshanks, Karen J (author)
Curtis, Sean P (author)
Davey-Smith, George (author)
Delles, Christian (author)
Gansevoort, Ron T (author)
Guo, Xiuqing (author)
Haiqing, Shen (author)
Hastie, Claire E (author)
Hofker, Marten H (author)
Hovingh, G Kees (author)
Kim, Daniel S (author)
Kirkland, Susan A (author)
Klein, Barbara E (author)
Klein, Ronald (author)
Li, Yun R (author)
Maiwald, Steffi (author)
Newton-Cheh, Christopher (author)
O'Brien, Eoin T (author)
Onland-Moret, N Charlotte (author)
Palmas, Walter (author)
Parsa, Afshin (author)
Penninx, Brenda W (author)
Pettinger, Mary (author)
Vasan, Ramachandran S (author)
Ranchalis, Jane E (author)
M Ridker, Paul (author)
Rose, Lynda M (author)
Sever, Peter (author)
Shimbo, Daichi (author)
Steele, Laura (author)
Stolk, Ronald P (author)
Thorand, Barbara (author)
Trip, Mieke D (author)
van Duijn, Cornelia M (author)
Verschuren, W Monique (author)
Wijmenga, Cisca (author)
Wyatt, Sharon (author)
Young, J Hunter (author)
Zwinderman, Aeilko H (author)
Bezzina, Connie R (author)
Boerwinkle, Eric (author)
Casas, Juan P (author)
Caulfield, Mark J (author)
Chakravarti, Aravinda (author)
Chasman, Daniel I (author)
Davidson, Karina W (author)
Doevendans, Pieter A (author)
Dominiczak, Anna F (author)
Fitzgerald, Garret A (author)
Gums, John G (author)
Fornage, Myriam (author)
Hakonarson, Hakon (author)
Halder, Indrani (author)
Hillege, Hans L (author)
Illig, Thomas (author)
Jarvik, Gail P (author)
Johnson, Julie A (author)
Kastelein, John J P (author)
Koenig, Wolfgang (author)
Kumari, Meena (author)
März, Winfried (author)
Murray, Sarah S (author)
O'Connell, Jeffery R (author)
Oldehinkel, Albertine J (author)
Pankow, James S (author)
Rader, Daniel J (author)
Redline, Susan (author)
Reilly, Muredach P (author)
Schadt, Eric E (author)
Kottke-Marchant, Kandice (author)
Snieder, Harold (author)
Snyder, Michael (author)
Stanton, Alice V (author)
Tobin, Martin D (author)
Uitterlinden, André G (author)
van der Harst, Pim (author)
van der Schouw, Yvonne T (author)
Samani, Nilesh J (author)
Watkins, Hugh (author)
Johnson, Andrew D (author)
Reiner, Alex P (author)
Zhu, Xiaofeng (author)
de Bakker, Paul I W (author)
Levy, Daniel (author)
Asselbergs, Folkert W (author)
Munroe, Patricia B (author)
Keating, Brendan J (author)
show less...
 (creator_code:org_t)
Elsevier BV, 2014
2014
English.
In: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297. ; 94:3, s. 349-360
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ∼50,000 SNPs in up to 87,736 individuals of European ancestry and combined these in a meta-analysis. We replicated findings in an independent set of 68,368 individuals of European ancestry. Our analyses identified 11 previously undescribed associations in independent loci containing 31 genes including PDE1A, HLA-DQB1, CDK6, PRKAG2, VCL, H19, NUCB2, RELA, HOXC@ complex, FBN1, and NFAT5 at the Bonferroni-corrected array-wide significance threshold (p < 6 × 10(-7)) and confirmed 27 previously reported associations. Bioinformatic analysis of the 11 loci provided support for a putative role in hypertension of several genes, such as CDK6 and NUCB2. Analysis of potential pharmacological targets in databases of small molecules showed that ten of the genes are predicted to be a target for small molecules. In summary, we identified previously unknown loci associated with BP. Our findings extend our understanding of genes involved in BP regulation, which may provide new targets for therapeutic intervention or drug response stratification.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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Tragante, Vinici ...
Barnes, Michael ...
Ganesh, Santhi K
Lanktree, Matthe ...
Guo, Wei
Franceschini, No ...
show more...
Smith, Erin N
Johnson, Toby
Holmes, Michael ...
Padmanabhan, San ...
Karczewski, Konr ...
Almoguera, Berta
Barnard, John
Baumert, Jens
Chang, Yen-Pei C ...
Elbers, Clara C
Farrall, Martin
Fischer, Mary E
Gaunt, Tom R
Gho, Johannes M ...
Gieger, Christia ...
Goel, Anuj
Gong, Yan
Isaacs, Aaron
Kleber, Marcus E
Leach, Irene Mat ...
McDonough, Caitr ...
Meijs, Matthijs ...
Melander, Olle
Nelson, Christop ...
Nolte, Ilja M
Pankratz, Nathan
Price, Tom S
Shaffer, Jonatha ...
Shah, Sonia
Tomaszewski, Mac ...
van der Most, Pe ...
Van Iperen, Erik ...
Vonk, Judith M
Witkowska, Kate
Wong, Caroline O ...
Zhang, Li
Beitelshees, Amb ...
Berenson, Gerald ...
Bhatt, Deepak L
Brown, Morris
Burt, Amber
Cooper-Dehoff, R ...
Connell, John M
Cruickshanks, Ka ...
Curtis, Sean P
Davey-Smith, Geo ...
Delles, Christia ...
Gansevoort, Ron ...
Guo, Xiuqing
Haiqing, Shen
Hastie, Claire E
Hofker, Marten H
Hovingh, G Kees
Kim, Daniel S
Kirkland, Susan ...
Klein, Barbara E
Klein, Ronald
Li, Yun R
Maiwald, Steffi
Newton-Cheh, Chr ...
O'Brien, Eoin T
Onland-Moret, N ...
Palmas, Walter
Parsa, Afshin
Penninx, Brenda ...
Pettinger, Mary
Vasan, Ramachand ...
Ranchalis, Jane ...
M Ridker, Paul
Rose, Lynda M
Sever, Peter
Shimbo, Daichi
Steele, Laura
Stolk, Ronald P
Thorand, Barbara
Trip, Mieke D
van Duijn, Corne ...
Verschuren, W Mo ...
Wijmenga, Cisca
Wyatt, Sharon
Young, J Hunter
Zwinderman, Aeil ...
Bezzina, Connie ...
Boerwinkle, Eric
Casas, Juan P
Caulfield, Mark ...
Chakravarti, Ara ...
Chasman, Daniel ...
Davidson, Karina ...
Doevendans, Piet ...
Dominiczak, Anna ...
Fitzgerald, Garr ...
Gums, John G
Fornage, Myriam
Hakonarson, Hako ...
Halder, Indrani
Hillege, Hans L
Illig, Thomas
Jarvik, Gail P
Johnson, Julie A
Kastelein, John ...
Koenig, Wolfgang
Kumari, Meena
März, Winfried
Murray, Sarah S
O'Connell, Jeffe ...
Oldehinkel, Albe ...
Pankow, James S
Rader, Daniel J
Redline, Susan
Reilly, Muredach ...
Schadt, Eric E
Kottke-Marchant, ...
Snieder, Harold
Snyder, Michael
Stanton, Alice V
Tobin, Martin D
Uitterlinden, An ...
van der Harst, P ...
van der Schouw, ...
Samani, Nilesh J
Watkins, Hugh
Johnson, Andrew ...
Reiner, Alex P
Zhu, Xiaofeng
de Bakker, Paul ...
Levy, Daniel
Asselbergs, Folk ...
Munroe, Patricia ...
Keating, Brendan ...
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
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American Journal ...
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Lund University

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