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Assessment of interactions between 205 breast cancer susceptibility loci and 13 established risk factors in relation to breast cancer risk, in the Breast Cancer Association Consortium

Kapoor, Pooja Middha (författare)
German Cancer Research Centre,Heidelberg University,German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.;Heidelberg Univ, Fac Med, Heidelberg, Germany.
Lindström, Sara (författare)
University of Washington,Fred Hutchinson Cancer Research Center,Univ Washington, Dept Epidemiol, Sch Publ Hlth, Seattle, WA 98195 USA.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
Behrens, Sabine (författare)
German Cancer Research Centre,German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.
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Wang, Xiaoliang (författare)
Fred Hutchinson Cancer Research Center,University of Washington,Univ Washington, Dept Epidemiol, Sch Publ Hlth, Seattle, WA 98195 USA.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
Michailidou, Kyriaki (författare)
Cyprus Institute of Neurology and Genetics,University of Cambridge,Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.;Cyprus Inst Neurol & Genet, Dept Electron Microscopy Mol Pathol, Nicosia, Cyprus.;Cyprus Inst Neurol & Genet, Cyprus Sch Mol Med, Nicosia, Cyprus.
Bolla, Manjeet K. (författare)
University of Cambridge,Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.
Wang, Qin (författare)
University of Cambridge,Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.
Dennis, Joe (författare)
University of Cambridge,Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.
Dunning, Alison M. (författare)
University of Cambridge,Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England.
Pharoah, Paul D.P. (författare)
University of Cambridge,Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England.
Schmidt, Marjanka K. (författare)
Antoni Van Leeuwenhoek Hospital,Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands.;Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Psychosocial Res & Epidemiol, Amsterdam, Netherlands.
Kraft, Peter (författare)
Harvard University,Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
García-Closas, Montserrat (författare)
National Cancer Institute, USA,Institute of Cancer Research London,NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.;Inst Canc Res, Div Genet & Epidemiol, London, England.
Easton, Douglas F. (författare)
University of Cambridge,Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England.
Milne, Roger L. (författare)
Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.;Monash Univ, Precis Med, Clayton, Vic, Australia.,Monash University
Chang-Claude, Jenny (författare)
University Medical Center Hamburg-Eppendorf,German Cancer Research Centre,German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.;UCCH, Canc Epidemiol Grp, Hamburg, Germany.
Augustinsson, Annelie (författare)
Lund University,Lunds universitet,Vård i högteknologisk miljö,Forskargrupper vid Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Biomarkörer och Epi,Institutionen för kliniska vetenskaper, Lund,Care in high technological environments,Lund University Research Groups,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Biomarkers and epidemiology,Department of Clinical Sciences, Lund
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 (creator_code:org_t)
 
2019-10-12
2020
Engelska 17 s.
Ingår i: International Journal of Epidemiology. - : Oxford University Press (OUP). - 0300-5771 .- 1464-3685. ; 49:1, s. 216-232
Relaterad länk:
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Previous gene-environment interaction studies of breast cancer risk have provided sparse evidence of interactions. Using the largest available dataset to date, we performed a comprehensive assessment of potential effect modification of 205 common susceptibility variants by 13 established breast cancer risk factors, including replication of previously reported interactions. Methods: Analyses were performed using 28 176 cases and 32 209 controls genotyped with iCOGS array and 44 109 cases and 48 145 controls genotyped using OncoArray from the Breast Cancer Association Consortium (BCAC). Gene-environment interactions were assessed using unconditional logistic regression and likelihood ratio tests for breast cancer risk overall and by estrogen-receptor (ER) status. Bayesian false discovery probability was used to assess the noteworthiness of the meta-analysed array-specific interactions. Results: Noteworthy evidence of interaction at ≤1% prior probability was observed for three single nucleotide polymorphism (SNP)-risk factor pairs. SNP rs4442975 was associated with a greater reduction of risk of ER-positive breast cancer [odds ratio (OR)int = 0.85 (0.78-0.93), Pint = 2.8 x 10-4] and overall breast cancer [ORint = 0.85 (0.78-0.92), Pint = 7.4 x 10-5) in current users of estrogen-progesterone therapy compared with non-users. This finding was supported by replication using OncoArray data of the previously reported interaction between rs13387042 (r2 = 0.93 with rs4442975) and current estrogen-progesterone therapy for overall disease (Pint = 0.004). The two other interactions suggested stronger associations between SNP rs6596100 and ER-negative breast cancer with increasing parity and younger age at first birth. Conclusions: Overall, our study does not suggest strong effect modification of common breast cancer susceptibility variants by established risk factors.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Breast cancer
Epidemiology
Europeans
Gene-environment interaction
Risk factors
Single nucleotide polymorphism
Gene-environment interaction

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