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Analyzing DNA methy...
Analyzing DNA methylation patterns in subjects diagnosed with schizophrenia using machine learning methods
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- Moghadam, Behrooz Torabi (författare)
- Uppsala universitet,Beräkningsbiologi och bioinformatik
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- Etemadikhah, Mitra (författare)
- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab
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- Rajkowska, Grazyna (författare)
- Univ Mississippi, Med Ctr, Dept Psychiat & Human Behav, Jackson, MS 39216 USA
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- Stocluneier, Craig (författare)
- Univ Mississippi, Med Ctr, Dept Psychiat & Human Behav, Jackson, MS 39216 USA
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- Grabherr, Manfred (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Komorowski, Jan (författare)
- Uppsala universitet,Beräkningsbiologi och bioinformatik,Polish Acad Sci, Inst Comp Sci, PL-01248 Warsaw, Poland
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- Feuk, Lars (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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- Lindholm Carlström, Eva (författare)
- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- PERGAMON-ELSEVIER SCIENCE LTD, 2019
- 2019
- Engelska.
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Ingår i: Journal of Psychiatric Research. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0022-3956 .- 1879-1379. ; 114, s. 41-47
- Relaterad länk:
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https://www.ncbi.nlm...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Schizophrenia is a common mental disorder with high heritability. It is genetically complex and to date more than a hundred risk loci have been identified. Association of environmental factors and schizophrenia has also been reported, while epigenetic analyses have yielded ambiguous and sometimes conflicting results. Here, we analyzed fresh frozen post-mortem brain tissue from a cohort of 73 subjects diagnosed with schizophrenia and 52 control samples, using the Illumina Infinium HumanMethylation450 Bead Chip, to investigate genome-wide DNA methylation patterns in the two groups. Analysis of differential methylation was performed with the Bioconductor Minfi package and modern machine-learning and visualization techniques, which were shown previously to be successful in detecting and highlighting differentially methylated patterns in case-control studies. In this dataset, however, these methods did not uncover any significant signals discerning the patient group and healthy controls, suggesting that if there are methylation changes associated with schizophrenia, they are heterogeneous and complex with small effect.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- DNA methylation
- Schizophrenia
- Machine learning
- Classification
- Clustering
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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