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Sensitivity of simu...
Sensitivity of simulated knee joint mechanics to selected human and bovine fibril-reinforced poroelastic material properties
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- Jahangir, Sana (author)
- University of Eastern Finland
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- Esrafilian, Amir (author)
- University of Eastern Finland
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- Ebrahimi, Mohammadhossein (author)
- University of Eastern Finland
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- Stenroth, Lauri (author)
- University of Copenhagen,University of Eastern Finland
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- Alkjær, Tine (author)
- University of Copenhagen,Frederiksberg Hospital
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- Henriksen, Marius (author)
- Frederiksberg Hospital
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- Englund, Martin (author)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund OsteoArthritis Division - Clinical Epidemiology Unit,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas
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- Mononen, Mika E. (author)
- University of Eastern Finland
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- Korhonen, Rami K. (author)
- University of Eastern Finland
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- Tanska, Petri (author)
- University of Eastern Finland
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Journal of Biomechanics. - 0021-9290. ; 160
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Fibril-reinforced poroviscoelastic material models are considered state-of-the-art in modeling articular cartilage biomechanics. Yet, cartilage material parameters are often based on bovine tissue properties in computational knee joint models, although bovine properties are distinctly different from those of humans. Thus, we aimed to investigate how cartilage mechanical responses are affected in the knee joint model during walking when fibril-reinforced poroviscoelastic properties of cartilage are based on human data instead of bovine. We constructed a finite element knee joint model in which tibial and femoral cartilages were modeled as fibril-reinforced poroviscoelastic material using either human or bovine data. Joint loading was based on subject-specific gait data. The resulting mechanical responses of knee cartilage were compared between the knee joint models with human or bovine fibril-reinforced poroviscoelastic cartilage properties. Furthermore, we conducted a sensitivity analysis to determine which fibril-reinforced poroviscoelastic material parameters have the greatest impact on cartilage mechanical responses in the knee joint during walking. In general, bovine cartilage properties yielded greater maximum principal stresses and fluid pressures (both up to 30%) when compared to the human cartilage properties during the loading response in both femoral and tibial cartilage sites. Cartilage mechanical responses were very sensitive to the collagen fibril-related material parameter variations during walking while they were unresponsive to proteoglycan matrix or fluid flow-related material parameter variations. Taken together, human cartilage material properties should be accounted for when the goal is to compare absolute mechanical responses of knee joint cartilage as bovine material parameters lead to substantially different cartilage mechanical responses.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Keyword
- Articular cartilage
- Fibril-reinforced poroelastic
- Finite element modeling
- Knee joint
- Material properties
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Jahangir, Sana
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Esrafilian, Amir
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Ebrahimi, Mohamm ...
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Stenroth, Lauri
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Alkjær, Tine
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Henriksen, Mariu ...
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show more...
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Englund, Martin
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Mononen, Mika E.
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Korhonen, Rami K ...
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Tanska, Petri
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Orthopaedics
- Articles in the publication
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Journal of Biome ...
- By the university
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Lund University