SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:umu-208256"
 

Sökning: onr:"swepub:oai:DiVA.org:umu-208256" > The role of inflamm...

The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts

Hou, Ruihua (författare)
Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, United Kingdom
Ye, Gang (författare)
Suzhou Guangji Hospital, Jiangsu, Suzhou, China
Cheng, Xiaojing (författare)
Shandong Mental Health Centre, Shandong, China
visa fler...
Shaw, Dominick E. (författare)
Respiratory Research Unit, University of Nottingham, Nottingham, United Kingdom
Bakke, Per S. (författare)
Department of Clinical Science, University of Bergen, Bergen, Norway
Caruso, Massimo (författare)
Dept of Clinical and Experimental, Medicine Hospital University, University of Catania, Catania, Italy
Dahlen, Barbro (författare)
The Centre for Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Dahlen, Sven-Erik (författare)
The Centre for Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Fowler, Stephen J. (författare)
Faculty of Biology, Medicine and Health, School of Biological Sciences, Division of Infection, Immunity & Respiratory Medicine, The University of Manchester and Manchester Academic Health Science Centre and NIHR Manchester Biomedical Research Unit and Manchester University NHS Foundation Trust, United Kingdom
Horváth, Ildikó (författare)
Dept of Pulmonology, Semmelweis University, Budapest, Hungary
Howarth, Peter (författare)
Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, United Kingdom
Krug, Norbert (författare)
Fraunhofer Institute for Toxicology and Experimental Medicine Hannover, Hannover, Germany
Montuschi, Paolo (författare)
Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy
Sanak, Marek (författare)
Department of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland
Sandström, Thomas, 1957- (författare)
Umeå universitet,Lungmedicin
Auffray, Charles (författare)
European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL-INSERM, Université de Lyon, France
De Meulder, Bertrand (författare)
European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL-INSERM, Université de Lyon, France
Sousa, Ana R. (författare)
Respiratory Therapeutic Unit, GlaxoSmithKline, Stockley Park, United Kingdom
Adcock, Ian M. (författare)
National Heart and Lung Institute, Imperial College London, United Kingdom
Fan Chung, Kian (författare)
National Heart and Lung Institute, Imperial College London, United Kingdom
Sterk, Peter J. (författare)
Amsterdam UMC, University of Amsterdam, Holland, Netherlands
Skipp, Paul J. (författare)
Biological Sciences, University of Southampton, Southampton, United Kingdom
Schofield, James (författare)
Biological Sciences, University of Southampton, Southampton, United Kingdom; NIHR Southampton Respiratory Biomedical Research Centre, United Kingdom
Djukanović, Ratko (författare)
Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, United Kingdom; NIHR Southampton Respiratory Biomedical Research Centre, United Kingdom
visa färre...
 (creator_code:org_t)
Academic Press, 2023
2023
Engelska.
Ingår i: Brain, behavior, and immunity. - : Academic Press. - 0889-1591 .- 1090-2139. ; 111, s. 249-258
Relaterad länk:
https://doi.org/10.1...
visa fler...
https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Growing evidence indicates high comorbid anxiety and depression in patients with asthma. However, the mechanisms underlying this comorbid condition remain unclear. The aim of this study was to investigate the role of inflammation in comorbid anxiety and depression in three asthma patient cohorts of the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) project. Methods: U-BIOPRED was conducted by a European Union consortium of 16 academic institutions in 11 European countries. A subset dataset from subjects with valid anxiety and depression measures and a large blood biomarker dataset were analysed, including 198 non-smoking patients with severe asthma (SAn), 65 smoking patients with severe asthma (SAs), 61 non-smoking patients with mild-to-moderate asthma (MMA), and 20 healthy non-smokers (HC). The Hospital Anxiety and Depression Scale was used to measure anxiety and depression and a series of inflammatory markers were analysed by the SomaScan v3 platform (SomaLogic, Boulder, Colo). ANOVA and the Kruskal-Wallis test were used for multiple-group comparisons as appropriate. Results: There were significant group effects on anxiety and depression among the four cohort groups (p < 0.05). Anxiety and depression of SAn and SAs groups were significantly higher than that of MMA and HC groups (p < 0.05. There were significant differences in serum IL6, MCP1, CCL18, CCL17, IL8, and Eotaxin among the four groups (p < 0.05). Depression was significantly associated with IL6, MCP1, CCL18 level, and CCL17; whereas anxiety was associated with CCL17 only (p < 0.05). Conclusions: The current study suggests that severe asthma patients are associated with higher levels of anxiety and depression, and inflammatory responses may underlie this comorbid condition.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Nyckelord

Anxiety
Asthma
Depression
Inflammation
U-BIOPRED

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy