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Sökning: onr:"swepub:oai:DiVA.org:oru-67268" > A Genetic Investiga...

A Genetic Investigation of Sex Bias in the Prevalence of Attention-Deficit/Hyperactivity Disorder

Martin, Joanna (författare)
Karolinska Institutet
Walters, Raymond K. (författare)
Stanley Center for Psychiatric Research, Broad Institute, Cambridge Massachusetts, United States; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston Massachusetts, United States
Demontis, Ditte (författare)
Centre for Integrative Sequencing [iSEQ], Aarhus University, Aarhus, Roskilde, Denmark; Department of Biomedicine–Human Genetics, Aarhus University, Aarhus, Roskilde, Denmark
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Mattheisen, Manuel (författare)
Karolinska Institutet
Lee, S. Hong (författare)
Queensland Brain Institute, University of Queensland, Brisbane Queensland, Australia; School of Environmental and Rural Science, University of New England, Armidale NSW, Australia; Centre for Population Health Research, School of Health Sciences and Sansom Institute of Health Research, University of South Australia, Adelaide, Australia
Robinson, Elise (författare)
Stanley Center for Psychiatric Research, Broad Institute, Cambridge Massachusetts, United States; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston Massachusetts, United States
Brikell, Isabell (författare)
Karolinska Institutet
Ghirardi, Laura (författare)
Karolinska Institutet
Larsson, Henrik, 1975- (författare)
Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, Sweden
Lichtenstein, Paul (författare)
Karolinska Institutet
Eriksson, Nicholas (författare)
23andMe Inc., Mountain View California, United States
Werge, Thomas (författare)
Lundbeck Foundation Initiative for Integrative Psychiatric Research [iPSYCH], Aarhus, Roskilde, Denmark; Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
Mortensen, Preben Bo (författare)
Lundbeck Foundation Initiative for Integrative Psychiatric Research [iPSYCH], Aarhus, Roskilde, Denmark; Centre for Integrative Sequencing [iSEQ], Aarhus University, Aarhus, Roskilde, Denmark; National Centre for Register-Based Research, Aarhus University, Aarhus, Roskilde, Denmark; Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Roskilde, Denmark
Pedersen, Marianne Giortz (författare)
Lundbeck Foundation Initiative for Integrative Psychiatric Research [iPSYCH], Aarhus, Roskilde, Denmark; National Centre for Register-Based Research, Aarhus University, Aarhus, Roskilde, Denmark; Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Roskilde, Denmark
Mors, Ole (författare)
Lundbeck Foundation Initiative for Integrative Psychiatric Research [iPSYCH], Aarhus, Roskilde, Denmark; Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark
Nordentoft, Merete (författare)
Lundbeck Foundation Initiative for Integrative Psychiatric Research [iPSYCH], Aarhus, Roskilde, Denmark; Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark
Hougaard, David M. (författare)
Lundbeck Foundation Initiative for Integrative Psychiatric Research [iPSYCH], Aarhus, Roskilde, Denmark; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark
Bybjerg-Grauholm, Jonas (författare)
Lundbeck Foundation Initiative for Integrative Psychiatric Research [iPSYCH], Aarhus, Roskilde, Denmark; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark
Wray, Naomi R. (författare)
Queensland Brain Institute, University of Queensland, Brisbane Queensland, Australia
Franke, Barbara (författare)
Departments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands
Faraone, Stephen V. (författare)
Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse NY, United States; K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway
O'Donovan, Michael C. (författare)
MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom
Thapar, Anita (författare)
MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom
Børglum, Anders D. (författare)
Lundbeck Foundation Initiative for Integrative Psychiatric Research [iPSYCH], Aarhus, Roskilde, Denmark; Centre for Integrative Sequencing [iSEQ], Aarhus University, Aarhus, Roskilde, Denmark; Department of Biomedicine–Human Genetics, Aarhus University, Aarhus, Roskilde, Denmark
Neale, Benjamin M. (författare)
Stanley Center for Psychiatric Research, Broad Institute, Cambridge Massachusetts, United States; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston Massachusetts, United States
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 (creator_code:org_t)
Elsevier, 2018
2018
Engelska.
Ingår i: Biological Psychiatry. - : Elsevier. - 0006-3223 .- 1873-2402. ; 83:12, s. 1044-1053
Relaterad länk:
https://doi.org/10.1...
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http://www.biologica...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) shows substantial heritability and is two to seven times more common in male individuals than in female individuals. We examined two putative genetic mechanisms underlying this sex bias: sex-specific heterogeneity and higher burden of risk in female cases.METHODS: We analyzed genome-wide autosomal common variants from the Psychiatric Genomics Consortium and iPSYCH Project (n = 20,183 cases, n = 35,191 controls) and Swedish population register data (n = 77,905 cases, n = 1,874,637 population controls).RESULTS: Genetic correlation analyses using two methods suggested near complete sharing of common variant effects across sexes, with r(g) estimates close to 1. Analyses of population data, however, indicated that female individuals with ADHD may be at especially high risk for certain comorbid developmental conditions (i.e., autism spectrum disorder and congenital malformations), potentially indicating some clinical and etiological heterogeneity. Polygenic risk score analysis did not support a higher burden of ADHD common risk variants in female cases (odds ratio [confidence interval] = 1.02 [0.98-1.06], p = .28). In contrast, epidemiological sibling analyses revealed that the siblings of female individuals with ADHD are at higher familial risk for ADHD than the siblings of affected male individuals (odds ratio [confidence interval] = 1.14 [1.11-1.18], p = 1.5E-15).CONCLUSIONS: Overall, this study supports a greater familial burden of risk in female individuals with ADHD and some clinical and etiological heterogeneity, based on epidemiological analyses. However, molecular genetic analyses suggest that autosomal common variants largely do not explain the sex bias in ADHD prevalence.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Nyckelord

ADHD
Epidemiology
GWAS
Neurodevelopmental disorders
Polygenic risk score analysis
Sex bias

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