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Cognitively defined...
Cognitively defined Alzheimer's dementia subgroups have distinct atrophy patterns
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- Crane, Paul K. (författare)
- Washington University School of Medicine
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- Groot, Colin (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Ossenkoppele, Rik (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Mukherjee, Shubhabrata (författare)
- Washington University School of Medicine
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- Choi, Seo Eun (författare)
- Washington University School of Medicine
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- Lee, Michael (författare)
- Washington University School of Medicine
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- Scollard, Phoebe (författare)
- Washington University School of Medicine
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- Gibbons, Laura E. (författare)
- Washington University School of Medicine
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- Sanders, R. Elizabeth (författare)
- Washington University School of Medicine
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- Trittschuh, Emily (författare)
- University of Washington
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- Saykin, Andrew J. (författare)
- Indiana University
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- Mez, Jesse (författare)
- Boston University
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- Nakano, Connie (författare)
- Washington University School of Medicine
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- Donald, Christine Mac (författare)
- University of Washington
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- Sohi, Harkirat (författare)
- University of Washington,Pacific Northwest National Laboratory
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- Risacher, Shannon (författare)
- Indiana University
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(creator_code:org_t)
- 2024
- 2024
- Engelska 14 s.
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Ingår i: Alzheimer's and Dementia. - 1552-5260. ; 20:3, s. 1739-1752
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- INTRODUCTION: We sought to determine structural magnetic resonance imaging (MRI) characteristics across subgroups defined based on relative cognitive domain impairments using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and to compare cognitively defined to imaging-defined subgroups. METHODS: We used data from 584 people with Alzheimer's disease (AD) (461 amyloid positive, 123 unknown amyloid status) and 118 amyloid-negative controls. We used voxel-based morphometry to compare gray matter volume (GMV) for each group compared to controls and to AD-Memory. RESULTS: There was pronounced bilateral lower medial temporal lobe atrophy with relative cortical sparing for AD-Memory, lower left hemisphere GMV for AD-Language, anterior lower GMV for AD-Executive, and posterior lower GMV for AD-Visuospatial. Formal asymmetry comparisons showed substantially more asymmetry in the AD-Language group than any other group (p = 1.15 × 10−10). For overlap between imaging-defined and cognitively defined subgroups, AD-Memory matched up with an imaging-defined limbic predominant group. DISCUSSION: MRI findings differ across cognitively defined AD subgroups.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimer's disease dementia
- asymmetry
- atrophy
- cognitive heterogeneity
- neurodegeneration
- subgroups
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Crane, Paul K.
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Groot, Colin
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Ossenkoppele, Ri ...
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Mukherjee, Shubh ...
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Choi, Seo Eun
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Lee, Michael
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visa fler...
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Scollard, Phoebe
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Gibbons, Laura E ...
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Sanders, R. Eliz ...
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Trittschuh, Emil ...
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Saykin, Andrew J ...
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Mez, Jesse
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Nakano, Connie
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Donald, Christin ...
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Sohi, Harkirat
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Risacher, Shanno ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Alzheimer's and ...
- Av lärosätet
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Lunds universitet