Sökning: WFRF:(Munck Lars Kristian) >
Efficacy and Safety...
Efficacy and Safety of Budesonide, vs Mesalazine or Placebo, as Induction Therapy for Lymphocytic Colitis
-
- Miehlke, Stephan (författare)
- Internal Med Ctr Eppendorf, Germany
-
- Aust, Daniela (författare)
- Tech Univ Dresden, Germany
-
- Mihaly, Emese (författare)
- Semmelweis Univ, Hungary
-
visa fler...
-
- Armerding, Peter (författare)
- Gastroenterology, Private Practice, Berlin, Germany
-
- Boehm, Guenther (författare)
- Internal Medicine and Cardiology, Private Practice, Ludwigshafen am Rhein, Germany
-
- Bonderup, Ole (författare)
- Reg Hosp Silkeborg, Denmark
-
- Fernandez-Banares, Fernando (författare)
- Hosp Univ Mutua Terrassa, Spain
-
- Kupcinskas, Juozas (författare)
- Lithuanian Univ Hlth Sci, Lithuania
-
- Munck, Lars Kristian (författare)
- Zealand Univ Hosp, Denmark; Univ Copenhagen, Denmark
-
- Rehbehn, Kai-Uwe (författare)
- Gastroenterology, Private Practice, Solingen, Germany
-
- Nacak, Tanju (författare)
- Dr Falk Pharma GmbH, Germany
-
- Greinwald, Roland (författare)
- Dr Falk Pharma GmbH, Germany
-
- Münch, Andreas, 1970- (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Magtarmmedicinska kliniken
-
visa färre...
-
(creator_code:org_t)
- W B SAUNDERS CO-ELSEVIER INC, 2018
- 2018
- Engelska.
-
Ingår i: Gastroenterology. - : W B SAUNDERS CO-ELSEVIER INC. - 0016-5085 .- 1528-0012. ; 155:6, s. 1795-
- Relaterad länk:
-
http://www.gastrojou...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND amp; AIMS: Lymphocytic colitis is a common cause of chronic, nonbloody diarrhea. However, the effects of treatment are unclear and randomized placebo-controlled trials were requested in a Cochrane review. We performed a randomized, placebo-controlled, multicenter study to evaluate budesonide and mesalazine as induction therapy for lymphocytic colitis. METHODS: Patients with active lymphocytic colitis were randomly assigned to groups given budesonide 9 mg once daily (Budenofalk granules), mesalazine 3 g once daily (Salofalk granules), or placebo for 8 weeks in a double-blind, double-dummy design. The primary endpoint was clinical remission, defined as amp;lt;= 21 stools (including amp;lt;= 6 watery stools), in the 7 days before week 8. RESULTS: The final analysis included 57 patients (19 per group). Most patients were female (72%) and the mean age was 59 years. The proportion of patients in clinical remission at week 8 was significantly higher in the budesonide group than in the placebo group (intention-to-treat analysis, 79% vs 42%; P=.01). The difference in proportions of patients in clinical remission at week 8 between the mesalazine (63%) and placebo groups was not significant (P=.09). The proportion of patients with histologic remission at week 8 was significantly higher in the budesonide group (68%) vs the mesalazine (26%; P=.02) or placebo (21%; P=.008) groups. The incidence of adverse events was 47.4% in the budesonide group, 68.4% in the mesalazine group, and 42.1% in the placebo group. CONCLUSIONS: In a randomized multicenter study, we found oral budesonide 9 mg once daily to be effective and safe for induction of clinical and histologic remission in patients with lymphocytic colitis, compared with placebo. Oral mesalazine 3 g once daily was not significantly better than placebo. ClinicalTrials.gov no: NCT01209208.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Corticosteroid; 5-Aminosalicylic Acid; Microscopic Colitis; Intraepithelial Lymphocytes
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Miehlke, Stephan
-
Aust, Daniela
-
Mihaly, Emese
-
Armerding, Peter
-
Boehm, Guenther
-
Bonderup, Ole
-
visa fler...
-
Fernandez-Banare ...
-
Kupcinskas, Juoz ...
-
Munck, Lars Kris ...
-
Rehbehn, Kai-Uwe
-
Nacak, Tanju
-
Greinwald, Rolan ...
-
Münch, Andreas, ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Gastroenterologi
- Artiklar i publikationen
-
Gastroenterology
- Av lärosätet
-
Linköpings universitet