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Sökning: onr:"swepub:oai:DiVA.org:oru-68770" > Outcome measures in...

Outcome measures in coeliac disease trials : the Tampere recommendations

Ludvigsson, Jonas F., 1969- (författare)
Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical epidemiology and Biostatistics, Karolinska institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden
Ciacci, Carolina (författare)
Coeliac Center at Department of Medicine and Surgery, Scuola Medica Salernitana, University of Salerno, Salerno, Italy
Green, Peter H. R. (författare)
Celiac Disease Center at Columbia University, New York, USA
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Kaukinen, Katri (författare)
Celiac Disease Research Center, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
Korponay-Szabo, Ilma R. (författare)
Coeliac Disease Centre, Heim Pál Children’s Hospital, Budapest, Hungary; Department of Paediatrics, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Kurppa, Kalle (författare)
Celiac Disease Research Center, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; Department of Paediatrics, Tampere University Hospital, Tampere, Finland
Murray, Joseph A. (författare)
The Mayo Clinic, Rochester Minnesota, USA
Lundin, Knut Erik Aslaksen (författare)
Institute of Clinical Medicine and K. G. Jebsen Coeliac Disease Research Centre, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway
Maki, Markku J. (författare)
Science Center, Tampere University Hospital, Tampere, Finland; Tampere Centre for Child Health Research, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
Popp, Alina (författare)
Institute for Mother and Child Health Bucharest, University of Medicine and Pharmacy ’Carol Davila’, Bucharest, Romania; Tampere Centre for Child Health Research, University of Tampere, Tampere University Hospital, Tampere,Finland
Reilly, Norelle R. (författare)
Division of Pediatric Gastroenterology, Columbia University Medical Center, New York, USA; Celiac Disease Center, Department of Medicine, Columbia University Medical Center, New York, USA
Rodriguez-Herrera, Alfonso (författare)
Gupo IHP Pediatria, Sevilla, Spain
Sanders, David S. (författare)
Academic Unit of Gastroenterology, Royal Hallamshire Hospital, University of Sheffield, Sheffield, UK
Schuppan, Detlef (författare)
Celiac Center, University Medical Center, Johannes-Gutenberg University, Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Sleet, Sarah (författare)
Coeliac UK, Buckinghamshire, UK
Taavela, Juha (författare)
Tampere Centre for Child Health Research, University of Tampere, Tampere University Hospital, Tampere, Finland
Voorhees, Kristin (författare)
Continuum Clinical, Northbrook, Illinois, USA
Walker, Marjorie M. (författare)
Faculty of Health and Medicine, School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia
Leffler, Daniel A. (författare)
Celiac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
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 (creator_code:org_t)
2018-02-13
2018
Engelska.
Ingår i: Gut. - : BMJ Publishing Group Ltd. - 0017-5749 .- 1468-3288. ; 67:8, s. 1410-1424
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Objective: A gluten-free diet is the only treatment option of coeliac disease, but recently an increasing number of trials have begun to explore alternative treatment strategies. We aimed to review the literature on coeliac disease therapeutic trials and issue recommendations for outcome measures.Design: Based on a literature review of 10 062 references, we (17 researchers and 2 patient representatives from 10 countries) reviewed the use and suitability of both clinical and non-clinical outcome measures. We then made expert-based recommendations for use of these outcomes in coeliac disease trials and identified areas where research is needed. Results: We comment on the use of histology, serology, clinical outcome assessment (including patient-reported outcomes), quality of life and immunological tools including gluten immunogenic peptides for trials in coeliac disease.Conclusion: Careful evaluation and reporting of outcome measures will increase transparency and comparability of coeliac disease therapeutic trials, and will benefit patients, healthcare and the pharmaceutical industry.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

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