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Sökning: onr:"swepub:oai:DiVA.org:oru-33895" > CYP2D6 Genotype and...

CYP2D6 Genotype and Adjuvant Tamoxifen : Meta-Analysis of Heterogeneous Study Populations

Province, M. A. (författare)
Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis MO, USA
Goetz, M. P. (författare)
Department of Oncology and Pharmacology, Mayo Clinic, Rochester MN, USA
Brauch, H. (författare)
Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; Tübingen University, Tübingen, Germany
visa fler...
Flockhare, D. A. (författare)
Division of Clinical Pharmacology, School of Medicine, Indiana University, Bloomington IN, USA
Hebert, J. M. (författare)
Department of Genetics, School of Medicine, Stanford University, Stanford CA, USA
Whaley, R. (författare)
Department of Genetics, School of Medicine, Stanford University, Stanford CA, USA
Suman, V. J. (författare)
Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester MO, USA
Schroth, W. (författare)
Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; Tübingen University, Tübingen, Germany
Winter, S. (författare)
Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology and University, Tuebingen, Germany
Zembutsu, H. (författare)
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Mushiroda, T. (författare)
Laboratory for Pharmacogenetics, RIKEN Center for Genomic Medicine, Yokohama, Japan
Newman, W. G. (författare)
Centre for Genetic Medicine, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK
Lee, M-TM. (författare)
Laboratory for International Alliance, RIKEN Center for Genomic Medicine, Yokohama, Japan
Ambrosone, C. B. (författare)
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo NY, USA
Beckmann, M. W. (författare)
Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
Choi, J-Y (författare)
Department of Biomedical Science, Graduate School, Seoul National University, Seoul, Korea
Dieudonne, A-S (författare)
Department of Oncology, Catholic University Leuven, Leuven, Belgium
Fasching, P. A. (författare)
Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany; Division of Hematology/Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles CA, USA
Ferraldeschi, R. (författare)
Centre for Genetic Medicine, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK
Gong, L. (författare)
Department of Genetics, School of Medicine, Stanford University, Stanford CA, USA
Haschke-Becher, E. (författare)
University Institute of Medical and Chemical Laboratory Diagnostics, Paracelsus Private Medical University, Salzburg, Austria
Howel, A. (författare)
The Christie NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
Jordan, L. B. (författare)
Department of Pathology, Ninewells Hospital and Medical School, Dundee, UK
Hamann, U. (författare)
Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Kiyotani, K. (författare)
Laboratory for Pharmacogenetics, RIKEN Center for Genomic Medicine, Yokohama, Japan
Krippl, P. (författare)
Medical University Graz, Graz, Austria
Lambrechts, D. (författare)
Vesalius Research Center, VIB and Laboratory of Translational Genetics, Department of Oncology, Catholic University Leuven, Leuven, Belgium
Latif, A. (författare)
Centre for Genetic Medicine, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK
Langsenlehner, U. (författare)
Medical University Graz, Graz, Austria
Lorizio, W. (författare)
Division of General Internal Medicine, Department of Medicine and Clinical Pharmacology and Experimental Therapeutics, and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco CA, USA
Neven, P. (författare)
Department of Gynecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium
Nguyen, A. T. (författare)
Division of Clinical Pharmacology, School of Medicine, Indiana University, Bloomington IN, USA
Park, B-W. (författare)
Department of Surgery, Yonsei University Health System, Seoul, Korea
Purdie, C. A. (författare)
Department of Pathology, Ninewells Hospital and Medical School, Dundee, UK
Quinlan, P. (författare)
Dundee Cancer Centre, Dundee, UK
Renner, W. (författare)
Medical University Graz, Graz, Austria
Schmidt, M. (författare)
Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; University Tübingen, Tübingen, Germany; Department of Gynecology and Obstetrics, University of Mainz, Mainz, Germany
Schwab, M. (författare)
Department of Clinical Pharmacology and Toxicology, University Hospital Tuebingen, Tuebingen, Germany
Shin, J-G (författare)
Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, Korea; Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, Korea
Stingl, J. C. (författare)
Division of Research, Federal Institute for Drugs and Medical Devices, University of Bonn Medical Faculty, Bonn, Germany
Wegman, Pia, 1964- (författare)
Örebro universitet,Hälsoakademin
Wingren, Sten, 1950- (författare)
Örebro universitet,Institutionen för läkarutbildning
Wu, A. H. B. (författare)
Department of Laboratory Medicine, University of California, San Francisco CA, USA
Ziv, E. (författare)
Division of General Internal Medicine, Department of Medicine and Clinical Pharmacology and Experimental Therapeutics, University of California, San Francisco CA, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco CA, USA
Zirpoli, G. (författare)
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo NY, USA
Thompson, A. M. (författare)
Dundee Cancer Centre, Dundee, UK
Jordan, V. C. (författare)
Department of Oncology, Georgetown University, Washington DC, USA
Nakamura, Y. (författare)
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Altman, R. B. (författare)
Department of Genetics, School of Medicine, Stanford University, Stanford CA, USA; Department of Bioengineering, Stanford University, Stanford CA, USA
Ames, M. M. (författare)
Department of Pharmacology, Mayo Clinic, Rochester MN, USA
Klein, T. E. (författare)
Department of Genetics, School of Medicine, Stanford University, Stanford CA, USA
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Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis MO, USA Department of Oncology and Pharmacology, Mayo Clinic, Rochester MN, USA (creator_code:org_t)
2013-09-23
2014
Engelska.
Ingår i: Clinical Pharmacology and Therapeutics. - New York, USA : Nature Publishing Group. - 0009-9236 .- 1532-6535. ; 95:2, s. 216-227
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The International Tamoxifen Pharmacogenomics Consortium was established to address the controversy regarding cytochrome P450 2D6 (CYP2D6) status and clinical outcomes in tamoxifen therapy. We performed a meta-analysis on data from 4,973 tamoxifen-treated patients (12 globally distributed sites). Using strict eligibility requirements (postmenopausal women with estrogen receptor-positive breast cancer, receiving 20 mg/day tamoxifen for 5 years, criterion 1), CYP2D6 poor metabolizer status was associated with poorer invasive disease-free survival (IDFS: hazard ratio = 1.25; 95% confidence interval = 1.06, 1.47; P = 0.009). However, CYP2D6 status was not statistically significant when tamoxifen duration, menopausal status, and annual follow-up were not specified (criterion 2, n = 2,443; P = 0.25) or when no exclusions were applied (criterion 3, n = 4,935; P = 0.38). Although CYP2D6 is a strong predictor of IDFS using strict inclusion criteria, because the results are not robust to inclusion criteria (these were not defined a priori), prospective studies are necessary to fully establish the value of CYP2D6 genotyping in tamoxifen therapy.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

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Medicine
Medicin

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