Consumption of Fish and Long-chain n-3 Polyunsaturated Fatty Acids Is Associated With Reduced Risk of Colorectal Cancer in a Large European Cohort

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Consumption of Fish and Long-chain n-3 Polyunsaturated Fatty Acids Is Associated With Reduced Risk of Colorectal Cancer in a Large European Cohort

Aglago, Elom K. (författare): International Agency for Research on Cancer, World Health Organization

Huybrechts, Inge (författare): International Agency for Research on Cancer, World Health Organization

Murphy, Neil (författare): International Agency for Research on Cancer, World Health Organization

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Casagrande, Corinne (författare): International Agency for Research on Cancer, World Health Organization,Aarhus University

Nicolas, Genevieve (författare): International Agency for Research on Cancer, World Health Organization

Pischon, Tobias (författare): Max Delbrück Center for Molecular Medicine (MDC)

Fedirko, Veronika (författare): Emory University Rollins School of Public Health

Severi, Gianluca (författare): University of Paris-Saclay

Boutron-Ruault, Marie Christine (författare): University of Paris-Saclay

Fournier, Agnès (författare): University of Paris-Saclay

Katzke, Verena (författare): German Cancer Research Centre

Kühn, Tilman (författare): German Cancer Research Centre

Olsen, Anja (författare): Danish Cancer Society

Tjønneland, Anne (författare): University of Copenhagen,Danish Cancer Society

Dahm, Christina C. (författare): Aarhus University

Overvad, Kim (författare): Aalborg University Hospital,Aarhus University

Lasheras, Cristina (författare): University of Oviedo

Agudo, Antonio (författare): L'Hospitalet de Llobregat, Barcelona,Catalan Institute of Oncology

Sánchez, Maria Jose (författare): University of Granada,CIBER Epidemiology and Public Health (CIBERESP)

Amiano, Pilar (författare): Biodonostia Health Research Institute

Huerta, José Maria (författare): CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council

Ardanaz, Eva (författare): CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)

Perez-Cornago, Aurora (författare): University of Oxford

Trichopoulou, Antonia (författare): National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens

Karakatsani, Anna (författare): International Agency for Research on Cancer, World Health Organization,Aalborg University Hospital,National and Kapodistrian University of Athens

Martimianaki, Georgia (författare): Hellenic Health Foundation, Athens

Palli, Domenico (författare): Institute for Cancer Research, Prevention and Clinical Network (ISPRO)

Pala, Valeria (författare): Istituto Nazionale dei Tumori

Tumino, Rosario (författare): Civic and M.P Arezzo Hospital

Naccarati, Alessio (författare): Italian Institute for Genomic Medicine (IIGM)

Panico, Salvatore (författare): University of Naples Federico II

Bueno-de-Mesquita, Bas (författare): National Institute for Public Health and the Environment (RIVM),University Medical Center Utrecht,University of Malaya,Imperial College London

May, Anne (författare): University Medical Center Utrecht

Derksen, Jeroen W.G. (författare): University Medical Center Utrecht

Hellstrand, Sophie (författare): Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups

Ohlsson, Bodil (författare): Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital

Wennberg, Maria, 1974- (författare): Umeå universitet,Umeå University,Avdelningen för hållbar hälsa

van Guelpen, Bethany (författare): Umeå universitet,Umeå University,Onkologi

Skeie, Guri (författare): UiT The Arctic University of Norway, Tromsø

Brustad, Magritt (författare): UiT The Arctic University of Norway, Tromsø

Weiderpass, Elisabete (författare): International Agency for Research on Cancer, World Health Organization

Cross, Amanda J. (författare): Imperial College London

Ward, Heather (författare): Imperial College London

Riboli, Elio (författare): Imperial College London

Norat, Teresa (författare): Imperial College London

Chajes, Veronique (författare): International Agency for Research on Cancer, World Health Organization

Gunter, Marc J. (författare): International Agency for Research on Cancer, World Health Organization

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(creator_code:org_t)

Elsevier BV, 2020
2020
Engelska.
Ingår i: Clinical Gastroenterology and Hepatology. - : Elsevier BV. - 1542-3565 .- 1542-7714. ; 18:3, s. 6-666

Relaterad länk:: http://dx.doi.org/10...; visa fler...; http://www.cghjourna...; https://www.cghjourn...; https://lup.lub.lu.s...; https://doi.org/10.1...; https://urn.kb.se/re...; visa färre...

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Background & Aims: There is an unclear association between intake of fish and long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFAs) and colorectal cancer (CRC). We examined the association between fish consumption, dietary and circulating levels of n-3 LC-PUFAs, and ratio of n-6:n-3 LC-PUFA with CRC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Dietary intake of fish (total, fatty/oily, lean/white) and n-3 LC-PUFA were estimated by food frequency questionnaires given to 521,324 participants in the EPIC study; among these, 6291 individuals developed CRC (median follow up, 14.9 years). Levels of phospholipid LC-PUFA were measured by gas chromatography in plasma samples from a sub-group of 461 CRC cases and 461 matched individuals without CRC (controls). Multivariable Cox proportional hazards and conditional logistic regression models were used to calculate hazard ratios (HRs) and odds ratios (ORs), respectively, with 95% CIs. Results: Total intake of fish (HR for quintile 5 vs 1, 0.88; 95% CI, 0.80–0.96; Ptrend = .005), fatty fish (HR for quintile 5 vs 1, 0.90; 95% CI, 0.82–0.98; Ptrend = .009), and lean fish (HR for quintile 5 vs 1, 0.91; 95% CI, 0.83–1.00; Ptrend = .016) were inversely associated with CRC incidence. Intake of total n-3 LC-PUFA (HR for quintile 5 vs 1, 0.86; 95% CI, 0.78–0.95; Ptrend = .010) was also associated with reduced risk of CRC, whereas dietary ratio of n-6:n-3 LC-PUFA was associated with increased risk of CRC (HR for quintile 5 vs 1, 1.31; 95% CI, 1.18–1.45; Ptrend < .001). Plasma levels of phospholipid n-3 LC-PUFA was not associated with overall CRC risk, but an inverse trend was observed for proximal compared with distal colon cancer (Pheterogeneity = .026). Conclusions: In an analysis of dietary patterns of participants in the EPIC study, we found regular consumption of fish, at recommended levels, to be associated with a lower risk of CRC, possibly through exposure to n-3 LC-PUFA. Levels of n-3 LC-PUFA in plasma were not associated with CRC risk, but there may be differences in risk at different regions of the colon.

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Av författaren/redakt...: Aglago, Elom K.; Huybrechts, Inge; Murphy, Neil; Casagrande, Cori ...; Nicolas, Genevie ...; Pischon, Tobias; visa fler...; Fedirko, Veronik ...; Severi, Gianluca; Boutron-Ruault, ...; Fournier, Agnès; Katzke, Verena; Kühn, Tilman; Olsen, Anja; Tjønneland, Anne; Dahm, Christina ...; Overvad, Kim; Lasheras, Cristi ...; Agudo, Antonio; Sánchez, Maria J ...; Amiano, Pilar; Huerta, José Mar ...; Ardanaz, Eva; Perez-Cornago, A ...; Trichopoulou, An ...; Karakatsani, Ann ...; Martimianaki, Ge ...; Palli, Domenico; Pala, Valeria; Tumino, Rosario; Naccarati, Aless ...; Panico, Salvator ...; Bueno-de-Mesquit ...; May, Anne; Derksen, Jeroen ...; Hellstrand, Soph ...; Ohlsson, Bodil; Wennberg, Maria, ...; van Guelpen, Bet ...; Skeie, Guri; Brustad, Magritt; Weiderpass, Elis ...; Cross, Amanda J.; Ward, Heather; Riboli, Elio; Norat, Teresa; Chajes, Veroniqu ...; Gunter, Marc J.; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Näringslära

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: Clinical Gastroe ...

Av lärosätet: Lunds universitet; Umeå universitet

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Consumption of Fish and Long-chain n-3 Polyunsaturated Fatty Acids Is Associated With Reduced Risk of Colorectal Cancer in a Large European Cohort

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