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Carfilzomib and dex...
Carfilzomib and dexamethasone maintenance following salvage ASCT in multiple myeloma : A randomised phase 2 trial by the Nordic Myeloma Study Group
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- Gregersen, Henrik (author)
- Aalborg Univ Hosp, Dept Haematol, Molleparkvej 4, DK-9000 Aalborg, Denmark.
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- Peceliunas, Valdas (author)
- Vilnius Univ, Hosp Santaros Klin, Dept Haematol, Vilnius, Lithuania.
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- Remes, Kari (author)
- Turku Univ Hosp, Dept Haematol, Turku, Finland.
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- Schjesvold, Fredrik (author)
- Oslo Univ Hosp, Oslo Myeloma Ctr, Oslo, Norway.;Univ Oslo, KG Jebsen Ctr B Cell Malignancies, Oslo, Norway.
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- Abildgaard, Niels (author)
- Odense Univ Hosp, Dept Haematol, Odense, Denmark.;Univ Southern Denmark, Dept Clin Res, Odense, Denmark.
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- Nahi, Hareth (author)
- Karolinska Institutet
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- Andersen, Niels Frost (author)
- Aarhus Univ Hosp, Dept Haematol, Aarhus, Denmark.
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- Vangsted, Annette Juul (author)
- Rigshosp, Dept Haematol, Copenhagen, Denmark.
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- Klausen, Tobias Wirenfeldt (author)
- Herlev Hosp, Dept Haematol, Herlev, Denmark.
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- Helleberg, Carsten (author)
- Herlev Hosp, Dept Haematol, Herlev, Denmark.
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- Carlson, Kristina (author)
- Uppsala universitet,Hematologi
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- Frolund, Ulf Christian (author)
- Zealand Univ Hosp, Dept Haematol, Roskilde, Denmark.
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- Axelsson, Per (author)
- Helsingborg Hosp, Dept Haematol, Helsingborg, Sweden.
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- Stromberg, Olga (author)
- Karolinska Univ Hosp, Dept Haematol, Stockholm, Sweden.
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- Blimark, Cecilie Hveding (author)
- Sahlgrens Univ Hosp, Dept Haematol, Gothenburg, Sweden.
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- Crafoord, Jacob (author)
- Örebro Univ Hosp, Dept Haematol, Örebro, Sweden.
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- Tsykunova, Galina (author)
- Haukeland Hosp, Dept Haematol, Bergen, Norway.
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- Eshoj, Henrik Rode (author)
- Odense Univ Hosp, Qual Life Res Ctr, Dept Haematol, Odense, Denmark.;Odense Univ Hosp, Open Patient Data Explorat Network, OPEN, Odense, Denmark.
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- Waage, Anders (author)
- Norwegian Univ Sci & Technol, St Olavs Hosp, Dept Haematol, Trondheim, Norway.;Norwegian Univ Sci & Technol, Inst Clin & Mol Med, Trondheim, Norway.
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- Hansson, Markus (author)
- Skane Univ Hosp, Dept Haematol, Lund, Sweden.
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- Gulbrandsen, Nina (author)
- Oslo Univ Hosp, Oslo Myeloma Ctr, Oslo, Norway.
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Aalborg Univ Hosp, Dept Haematol, Molleparkvej 4, DK-9000 Aalborg, Denmark Vilnius Univ, Hosp Santaros Klin, Dept Haematol, Vilnius, Lithuania. (creator_code:org_t)
- 2021-10-11
- 2022
- English.
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In: European Journal of Haematology. - : John Wiley & Sons. - 0902-4441 .- 1600-0609. ; 108:1, s. 34-44
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Abstract
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- Objective We investigated the efficacy and safety of carfilzomib-containing induction before salvage high-dose melphalan with autologous stem-cell transplantation (salvage ASCT) and maintenance with carfilzomib and dexamethasone after salvage ASCT in multiple myeloma. Methods This randomised, open-label, phase 2 trial included patients with first relapse of multiple myeloma after upfront ASCT who were re-induced with four cycles of carfilzomib, cyclophosphamide and dexamethasone. Two months after salvage, ASCT patients were randomised to either observation or maintenance therapy with iv carfilzomib 27 -> 56 mg/sqm and p.o. dexamethasone 20 mg every second week. The study enrolled 200 patients of which 168 were randomised to either maintenance with carfilzomib and dexamethasone (n = 82) or observation (n = 86). Results Median time to progression (TTP) after randomisation was 25.1 months (22.5-NR) in the carfilzomib-dexamethasone maintenance group and 16.7 months (14.4-21.8) in the control group (HR 0.46, 95% CI 0.30-0.71; P = .0004). The most common adverse events during maintenance were thrombocytopenia, anaemia, hypertension, dyspnoea and bacterial infections. Conclusion In summary, maintenance therapy with carfilzomib and dexamethasone after salvage ASCT prolonged TTP with 8 months. The maintenance treatment was in general well-tolerated with manageable toxicity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- carfilzomib
- induction chemotherapy
- maintenance chemotherapy
- multiple myeloma
- salvage therapy
Publication and Content Type
- ref (subject category)
- art (subject category)
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Gregersen, Henri ...
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Peceliunas, Vald ...
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Remes, Kari
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Schjesvold, Fred ...
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Abildgaard, Niel ...
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Nahi, Hareth
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Andersen, Niels ...
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Vangsted, Annett ...
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Klausen, Tobias ...
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Helleberg, Carst ...
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Carlson, Kristin ...
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Frolund, Ulf Chr ...
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Axelsson, Per
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Stromberg, Olga
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Blimark, Cecilie ...
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Crafoord, Jacob
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Tsykunova, Galin ...
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Eshoj, Henrik Ro ...
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Waage, Anders
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Hansson, Markus
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Gulbrandsen, Nin ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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European Journal ...
- By the university
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Uppsala University
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Karolinska Institutet