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Sökning: onr:"swepub:oai:DiVA.org:oru-95676" > Sex-Specific Metabo...

Sex-Specific Metabolic Pathways Were Associated with Alzheimer's Disease (AD) Endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery Cohort

Xu, Jin (författare)
Institute of Pharmaceutical Science, King's College London, London, UK; Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK
Green, Rebecca (författare)
Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK; NIHR Maudsley Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK
Kim, Min (författare)
Steno Diabetes Center, Gentofte, Denmark
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Lord, Jodie (författare)
Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK
Ebshiana, Amera (författare)
Institute of Pharmaceutical Science, King's College London, London, UK
Westwood, Sarah (författare)
Department of Psychiatry, University of Oxford, Oxford, UK
Baird, Alison L. (författare)
Department of Psychiatry, University of Oxford, Oxford, UK
Nevado-Holgado, Alejo J. (författare)
Department of Psychiatry, University of Oxford, Oxford, UK
Shi, Liu (författare)
Department of Psychiatry, University of Oxford, Oxford, UK
Hye, Abdul (författare)
Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK
Snowden, Stuart G. (författare)
Institute of Pharmaceutical Science, King's College London, London, UK
Bos, Isabelle (författare)
Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands
Vos, Stephanie J. B. (författare)
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands
Vandenberghe, Rik (författare)
Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
Teunissen, Charlotte E. (författare)
Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
Kate, Mara Ten (författare)
Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands; Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
Scheltens, Philip (författare)
Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
Gabel, Silvy (författare)
Department of Clinical Chemistry, Neurochemistry Laboratory, Amsterdam Neuroscience, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, The Netherlands; Department of Neurosciences, Laboratory for Cognitive Neurology, KU Leuven, Leuven, Belgium; University Hospital Leuven, Leuven, Belgium
Meersmans, Karen (författare)
Department of Neurosciences, Laboratory for Cognitive Neurology, KU Leuven, Leuven, Belgium; University Hospital Leuven, Leuven, Belgium
Blin, Olivier (författare)
Clinical Pharmacology & Pharmacovigilance Department, Aix-Marseille University-CNRS, Marseille, France
Richardson, Jill (författare)
Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage, UK
De Roeck, Ellen Elisa (författare)
Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium
Engelborghs, Sebastiaan (författare)
Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; Department of Neurology and Center for Neurosciences (C4N), UZ Brussel and Vrije Universiteit Brussel (VUB), 1050 Brussels, Belgium
Sleegers, Kristel (författare)
Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, University of Antwerp, Antwerp, Belgium; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium
Bordet, Régis (författare)
Department of Medical Pharmacology, Université de Lille, Lille, France
Rami, Lorena (författare)
Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic of Barcelona, August Pi Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain
Kettunen, Petronella (författare)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Tsolaki, Magda (författare)
1st Department of Neurology, AHEPA University Hospital, Thessaloniki, Greece
Verhey, Frans R. J. (författare)
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands
Alcolea, Daniel (författare)
Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Lleó, Alberto (författare)
Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Peyratout, Gwendoline (författare)
Lausanne University Hospital, Lausanne, Switzerland
Tainta, Mikel (författare)
Fundación CITA-Alzhéimer Fundazioa, San Sebastian, Spain
Johannsen, Peter (författare)
Danish Dementia Research Centre, Rigshospitalet, Copenhagen, Denmark
Freund-Levi, Yvonne, 1956- (författare)
Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Frölich, Lutz (författare)
Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Dobricic, Valerija (författare)
Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany
Frisoni, Giovanni B. (författare)
Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Molinuevo, José Luis (författare)
Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic of Barcelona, August Pi Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain; Barcelona Beta Brain Research Center, Unversitat Pompeu Fabra, Barcelona, Spain
Wallin, Anders, 1950 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre for Ageing and Health (Agecap)
Popp, Julius (författare)
Old Age Psychiatry, Department of Psychiatry, University Hospital Lausanne, Lausanne, Switzerland; Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, Zürich, Switzerland
Martinez-Lage, Pablo (författare)
Center for Research and Advanced Therapies, CITA-Alzheimer Foundation, San Sebastian, Spain
Bertram, Lars (författare)
Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany; Department of Psychology, University of Oslo, Oslo, Norway
Blennow, Kaj, 1958 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Zetterberg, Henrik, 1973 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Streffer, Johannes (författare)
Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium
Visser, Pieter Jelle (författare)
Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands
Lovestone, Simon (författare)
Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK; Department of Psychiatry, University of Oxford, Oxford, UK; Janssen-Cilag UK Ltd., Oxford, UK
Proitsi, Petroula (författare)
Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK
Legido-Quigley, Cristina (författare)
Institute of Pharmaceutical Science, King's College London, London, UK; Steno Diabetes Center, Gentofte, Denmark
The European Medical Information Framework Consortium, - (bidragsgivare)
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 (creator_code:org_t)
2021-11-03
2021
Engelska.
Ingår i: Biomedicines. - : MDPI. - 2227-9059. ; 9:11
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: physiological differences between males and females could contribute to the development of Alzheimer's Disease (AD). Here, we examined metabolic pathways that may lead to precision medicine initiatives.METHODS: We explored whether sex modifies the association of 540 plasma metabolites with AD endophenotypes including diagnosis, cerebrospinal fluid (CSF) biomarkers, brain imaging, and cognition using regression analyses for 695 participants (377 females), followed by sex-specific pathway overrepresentation analyses, APOE ε4 stratification and assessment of metabolites' discriminatory performance in AD.RESULTS: In females with AD, vanillylmandelate (tyrosine pathway) was increased and tryptophan betaine (tryptophan pathway) was decreased. The inclusion of these two metabolites (area under curve (AUC) = 0.83, standard error (SE) = 0.029) to a baseline model (covariates + CSF biomarkers, AUC = 0.92, SE = 0.019) resulted in a significantly higher AUC of 0.96 (SE = 0.012). Kynurenate was decreased in males with AD (AUC = 0.679, SE = 0.046).CONCLUSIONS: metabolic sex-specific differences were reported, covering neurotransmission and inflammation pathways with AD endophenotypes. Two metabolites, in pathways related to dopamine and serotonin, were associated to females, paving the way to personalised treatment.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Nyckelord

Alzheimer’s disease
blood
metabolic pathway
metabolomics
sex
tryptophan betaine
vanillylmandelate
Alzheimer’s disease
blood
metabolic pathway
metabolomics
sex
tryptophan betaine
vanillylmandelate

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