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Molecular and Pathology Features of Colorectal Tumors and Patient Outcomes Are Associated with Fusobacterium nucleatum and Its Subspecies animalis

Borozan, Ivan (författare)
Ontario Institute for Cancer Research, ON, Toronto, Canada
Zaidi, Syed H. (författare)
Ontario Institute for Cancer Research, ON, Toronto, Canada
Harrison, Tabitha A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States
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Phipps, Amanda I. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States
Zheng, Jiayin (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States
Lee, Stephen (författare)
Ontario Institute for Cancer Research, ON, Toronto, Canada
Trinh, Quang M. (författare)
Ontario Institute for Cancer Research, ON, Toronto, Canada
Steinfelder, Robert S. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States
Adams, Jeremy (författare)
Ontario Institute for Cancer Research, ON, Toronto, Canada
Banbury, Barbara L. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States
Berndt, Sonja I. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Brezina, Stefanie (författare)
Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria
Buchanan, Daniel D. (författare)
Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, VIC, Parkville, Australia; The University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia; Familial Cancer Clinic, Genetic Medicine, The Royal Melbourne Hospital, VIC, Parkville, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Parkville, Australia
Bullman, Susan (författare)
Human Biology Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Cao, Yin (författare)
Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis, St Louis, MO, United States; Siteman Cancer Center, Washington University School of Medicine in St. Louis, St Louis, MO, United States
Farris III, Alton B. (författare)
Pathology and Laboratory Medicine, Emory University, School of Medicine, GA, Atlanta, United States
Figueiredo, Jane C. (författare)
Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States
Giannakis, Marios (författare)
Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, MA, Boston, United States; Broad Institute of MIT and Harvard, MA, Cambridge, United States
Heisler, Lawrence E. (författare)
Ontario Institute for Cancer Research, ON, Toronto, Canada
Hopper, John L. (författare)
The University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia
Lin, Yi (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States
Luo, Xuemei (författare)
Ontario Institute for Cancer Research, ON, Toronto, Canada
Nishihara, Reiko (författare)
Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States
Mardis, Elaine R. (författare)
The Steve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute, Nationwide Children's Hospital, OH, Columbus, United States
Papadopoulos, Nickolas (författare)
Ludwig Center for Cancer Genetics and Therapeutics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, MD, Baltimore, United States
Qu, Conghui (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States
Reid, Emma E.G. (författare)
Ontario Institute for Cancer Research, ON, Toronto, Canada
Thibodeau, Stephen N. (författare)
Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States
Harlid, Sophia, 1978- (författare)
Umeå universitet,Onkologi
Um, Caroline Y. (författare)
Behavioral and Epidemiology Research Group, American Cancer Society, GA, Atlanta, United States
Hsu, Li (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States; Department of Biostatistics, School of Public Health, University of Washington, WA, Seattle, United States
Gsur, Andrea (författare)
Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria
Campbell, Peter T. (författare)
Behavioral and Epidemiology Research Group, American Cancer Society, GA, Atlanta, United States
Gallinger, Steven (författare)
Ontario Institute for Cancer Research, ON, Toronto, Canada; Lunenfeld-Tanenbaum Research Institute, Sinai Health, University of Toronto, ON, Toronto, Canada; General Surgery, Surgery and Critical Care Program, University Health Network Toronto General Hospital, University of Toronto, ON, Toronto, Canada
Newcomb, Polly A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States
Ogino, Shuji (författare)
Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Cancer Immunology Program, Dana-Farber/Harvard Cancer Center, MA, Boston, United States; Cancer Epidemiology Program, Dana-Farber/Harvard Cancer Center, MA, Boston, United States
Sun, Wei (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States
Hudson, Thomas J. (författare)
Ontario Institute for Cancer Research, ON, Toronto, Canada
Ferretti, Vincent (författare)
Ontario Institute for Cancer Research, ON, Toronto, Canada; CHU Sainte-Justine Research Center, University of Montreal, QC, Montreal, Canada
Peters, Ulrike (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States
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 (creator_code:org_t)
American Association for Cancer Research, 2022
2022
Engelska.
Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 31:1, s. 210-220
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Fusobacterium nucleatum (F. nucleatum) activates oncogenic signaling pathways and induces inflammation to promote colorectal carcinogenesis.Methods: We characterized F. nucleatum and its subspecies in colorectal tumors and examined associations with tumor characteristics and colorectal cancer-specific survival. We conducted deep sequencing of nusA, nusG, and bacterial 16s rRNA genes in tumors from 1,994 patients with colorectal cancer and assessed associations between F. nucleatum presence and clinical characteristics, colorectal cancer-specific mortality, and somatic mutations.Results: F. nucleatum, which was present in 10.3% of tumors, was detected in a higher proportion of right-sided and advanced-stage tumors, particularly subspecies animalis. Presence of F. nucleatum was associated with higher colorectal cancer-specific mortality (HR, 1.97; P = 0.0004). This association was restricted to nonhypermutated, microsatellite-stable tumors (HR, 2.13; P = 0.0002) and those who received chemotherapy [HR, 1.92; confidence interval (CI), 1.07-3.45; P = 0.029). Only F. nucleatum subspecies animalis, the main subspecies detected (65.8%), was associated with colorectal cancer-specific mortality (HR, 2.16; P = 0.0016), subspecies vincentii and nucleatum were not (HR, 1.07; P = 0.86). Additional adjustment for tumor stage suggests that the effect of F. nucleatum on mortality is partly driven by a stage shift. Presence of F. nucleatum was associated with microsatellite instable tumors, tumors with POLE exonuclease domain mutations, and ERBB3 mutations, and suggestively associated with TP53 mutations.Conclusions: F. nucleatum, and particularly subspecies animalis, was associated with a higher colorectal cancer-specific mortality and specific somatic mutated genes.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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