Expression of phosphofructokinase in skeletal muscle is influenced by genetic variation and associated with insulin sensitivity.

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Sökning: onr:"swepub:oai:DiVA.org:uu-275685" > Expression of phosp...

1 av 1
Föregående post
Nästa post
Till träfflistan

Expression of phosphofructokinase in skeletal muscle is influenced by genetic variation and associated with insulin sensitivity.

Keildson, Sarah (författare): Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom,Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

Fadista, Joao (författare): Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University, Malmö, Sweden

Ladenvall, Claes (författare): Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University, Malmö, Sweden

visa fler...

Hedman, Åsa K (författare): Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Elgzyri, Targ (författare): Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University, Malmö, Sweden,Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland

Small, Kerrin S (författare)

Grundberg, Elin (författare): Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

Nica, Alexandra C (författare): Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland

Glass, Daniel (författare): Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

Richards, J Brent (författare): Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

Barrett, Amy (författare): Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom

Nisbet, James (författare): Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

Zheng, Hou-Feng (författare): Department of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Jewish General Hospital, Montreal, QC, Canada

Rönn, Tina (författare): Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University, Malmö, Sweden

Ström, Kristoffer (författare): Mittuniversitetet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Avdelningen för hälsovetenskap,NVC

Eriksson, Karl-Fredrik (författare): Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University, Malmö, Sweden

Prokopenko, Inga (författare): Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Spector, Timothy D (författare): Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

Dermitzakis, Emmanouil T (författare)

Deloukas, Panos (författare): Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

McCarthy, Mark I (författare): Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Rung, Johan (författare): European Molecular Biology Laboratory-European Bioinformatics Institute, Cambridge, United Kingdom

Groop, Leif (författare): Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University, Malmö, Sweden

Franks, Paul (författare): Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Department of Clinical Sciences, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Lund University, Malmö, Sweden

Lindgren, Cecilia M (författare): Broad Institute of Massachusetts Institute of Technology, Harvard University, Cambridge, MA, USA

Hansson, Ola (författare): Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University, Malmö, Sweden

visa färre...

(creator_code:org_t)

2014-02-13
2014
Engelska.
Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 63:3

Relaterad länk:: https://diabetes.dia...; visa fler...; http://dx.doi.org/10...; https://miun.diva-po... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.2...; https://lup.lub.lu.s...; https://urn.kb.se/re...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Using an integrative approach in which genetic variation, gene expression, and clinical phenotypes are assessed in relevant tissues may help functionally characterize the contribution of genetics to disease susceptibility. We sought to identify genetic variation influencing skeletal muscle gene expression (expression quantitative trait loci [eQTLs]) as well as expression associated with measures of insulin sensitivity. We investigated associations of 3,799,401 genetic variants in expression of >7,000 genes from three cohorts (n = 104). We identified 287 genes with cis-acting eQTLs (false discovery rate [FDR] <5%; P < 1.96 × 10(-5)) and 49 expression-insulin sensitivity phenotype associations (i.e., fasting insulin, homeostasis model assessment-insulin resistance, and BMI) (FDR <5%; P = 1.34 × 10(-4)). One of these associations, fasting insulin/phosphofructokinase (PFKM), overlaps with an eQTL. Furthermore, the expression of PFKM, a rate-limiting enzyme in glycolysis, was nominally associated with glucose uptake in skeletal muscle (P = 0.026; n = 42) and overexpressed (Bonferroni-corrected P = 0.03) in skeletal muscle of patients with T2D (n = 102) compared with normoglycemic controls (n = 87). The PFKM eQTL (rs4547172; P = 7.69 × 10(-6)) was nominally associated with glucose uptake, glucose oxidation rate, intramuscular triglyceride content, and metabolic flexibility (P = 0.016-0.048; n = 178). We explored eQTL results using published data from genome-wide association studies (DIAGRAM and MAGIC), and a proxy for the PFKM eQTL (rs11168327; r(2) = 0.75) was nominally associated with T2D (DIAGRAM P = 2.7 × 10(-3)). Taken together, our analysis highlights PFKM as a potential regulator of skeletal muscle insulin sensitivity.

Hitta via bibliotek

Diabetes (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Endokrinologi oc ...

Artiklar i publikationen: Diabetes

Av lärosätet: Uppsala universitet; Lunds universitet; Mittuniversitetet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Expression of phosphofructokinase in skeletal muscle is influenced by genetic variation and associated with insulin sensitivity.

Ämnesord

Publikations- och innehållstyp

Hitta via bibliotek

Till lärosätets databas

Hitta mer i SwePub

Sök utanför SwePub