Sökning: WFRF:(Niméus Emma) >
Regulatory interpla...
Regulatory interplay between mir-181a-5p and estrogen receptor signaling cascade in breast cancer
-
- Benedetti, Rosaria (författare)
- University of Campania Luigi Vanvitelli
-
- Papulino, Chiara (författare)
- University of Campania Luigi Vanvitelli
-
- Sgueglia, Giulia (författare)
- University of Campania Luigi Vanvitelli
-
visa fler...
-
- Chianese, Ugo (författare)
- University of Campania Luigi Vanvitelli
-
- De Marchi, Tommaso (författare)
- Lund University,Lunds universitet,Bröstcancer Proteogenomik,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breast cancer Proteogenomics,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
-
- Iovino, Francesco (författare)
- University of Campania Luigi Vanvitelli
-
- Rotili, Dante (författare)
- Sapienza University of Rome
-
- Mai, Antonello (författare)
- Sapienza University of Rome
-
- Niméus, Emma (författare)
- Lund University,Lunds universitet,Bröstcancer Proteogenomik,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breast cancer Proteogenomics,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
-
- Aversana, Carmela Dell’ (författare)
- CNR Institute Experimental Endocrinology and Oncology "Gaetano Salvatore" (IEOS),University of Campania Luigi Vanvitelli
-
- Altucci, Lucia (författare)
- University of Campania Luigi Vanvitelli
-
visa färre...
-
(creator_code:org_t)
- 2021-02-01
- 2021
- Engelska 19 s.
-
Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 13:3
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://www.mdpi.com...
-
https://lup.lub.lu.s...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- The efficacy and side effects of endocrine therapy in breast cancer (BC) depend largely on estrogen receptor alpha (ERα) expression, the specific drug administered, and treatment scheduling. Although the benefits of endocrine therapy outweigh any adverse effects in the initial stages of BC, later- or advanced-stage tumors acquire resistance to treatments. The mechanisms underlying tumor resistance to therapy are still not well understood, posing a major challenge for BC patient care. Epigenetic regulation and miRNA expression may be involved in the switch from a treatment-sensitive to a treatment-resistant state and could provide a valid therapeutic strategy for ERα negative BC. Here, a hybrid lysine-specific histone demethylase inhibitor, MC3324, displaying selective estrogen receptor down-regulator-like activities in BC, was used to highlight the interplay between epigenetic and ERα signaling. MC3324 anticancer action is mediated by microRNA (miRNA) expression regulation, indicating an innovative function for this molecule. Integrated analysis suggests a crosstalk between estrogen signaling, ERα interactors, miRNAs, and their putative targets. Specifically, miR-181a-5p expression is regulated by MC3324 and has an impact on cellular levels of ERα. A comparison of breast tumor versus healthy mammary tissues confirmed the important role of miR-181a-5p in ERα regulation and points to its putative predictive function in BC therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Breast cancer
- Endocrine therapy
- Epigenetic SERD
- ERα
- Hormone signaling
- MiR-181a-5p
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
-
Cancers
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Benedetti, Rosar ...
-
Papulino, Chiara
-
Sgueglia, Giulia
-
Chianese, Ugo
-
De Marchi, Tomma ...
-
Iovino, Francesc ...
-
visa fler...
-
Rotili, Dante
-
Mai, Antonello
-
Niméus, Emma
-
Aversana, Carmel ...
-
Altucci, Lucia
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Cancers
- Av lärosätet
-
Lunds universitet