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Common variants at 6q22 and 17q21 are associated with intracranial volume

Ikram, M. Arfan (author)
Fornage, Myriam (author)
Smith, Albert V. (author)
show more...
Seshadri, Sudha (author)
Schmidt, Reinhold (author)
Debette, Stephanie (author)
Vrooman, Henri A. (author)
Sigurdsson, Sigurdur (author)
Ropele, Stefan (author)
Taal, H. Rob (author)
Mook-Kanamori, Dennis O. (author)
Coker, Laura H. (author)
Longstreth, W. T., Jr. (author)
Niessen, Wiro J. (author)
DeStefano, Anita L. (author)
Beiser, Alexa (author)
Zijdenbos, Alex P. (author)
Struchalin, Maksim (author)
Jack, Clifford R., Jr. (author)
Rivadeneira, Fernando (author)
Uitterlinden, Andre G. (author)
Knopman, David S. (author)
Hartikainen, Anna-Liisa (author)
Pennell, Craig E. (author)
Thiering, Elisabeth (author)
Steegers, Eric A. P. (author)
Hakonarson, Hakon (author)
Heinrich, Joachim (author)
Palmer, Lyle J. (author)
Jarvelin, Marjo-Riitta (author)
McCarthy, Mark I. (author)
Grant, Struan F. A. (author)
St Pourcain, Beate (author)
Timpson, Nicholas J. (author)
Smith, George Davey (author)
Sovio, Ulla (author)
Nalls, Mike A. (author)
Au, Rhoda (author)
Hofman, Albert (author)
Gudnason, Haukur (author)
van der Lugt, Aad (author)
Harris, Tamara B. (author)
Meeks, William M. (author)
Vernooij, Meike W. (author)
van Buchem, Mark A. (author)
Catellier, Diane (author)
Jaddoe, Vincent W. V. (author)
Gudnason, Vilmundur (author)
Windham, B. Gwen (author)
Wolf, Philip A. (author)
van Duijn, Cornelia M. (author)
Mosley, Thomas H., Jr. (author)
Schmidt, Helena (author)
Launer, Lenore J. (author)
Breteler, Monique M. B. (author)
DeCarli, Charles (author)
Adair, Linda S. (author)
Ang, Wei (author)
Atalay, Mustafa (author)
vanBeijsterveldt, Toos (author)
Bergen, Nienke (author)
Benke, Kelly (author)
Berry, Diane (author)
Coin, Lachlan (author)
Davis, Oliver S. P. (author)
Elliott, Paul (author)
Flexeder, Claudia (author)
Frayling, Tim (author)
Gaillard, Romy (author)
Groen-Blokhuis, Maria (author)
Goh, Liang-Kee (author)
Haworth, Claire M. A. (author)
Hadley, Dexter (author)
Hedebrand, Johannes (author)
Hinney, Anke (author)
Hirschhorn, Joel N. (author)
Holloway, John W. (author)
Holst, Claus (author)
Hottenga, Jouke Jan (author)
Horikoshi, Momoko (author)
Huikari, Ville (author)
Hypponen, Elina (author)
Kilpelainen, Tuomas O. (author)
Kirin, Mirna (author)
Kowgier, Matthew (author)
Lakka, Hanna-Maaria (author)
Lange, Leslie A. (author)
Lawlor, Debbie A. (author)
Lehtimaki, Terho (author)
Lewin, Alex (author)
Lindgren, Cecilia (author)
Lindi, Virpi (author)
Maggi, Reedik (author)
Marsh, Julie (author)
Middeldorp, Christel (author)
Millwood, Iona (author)
Murray, Jeffrey C. (author)
Nivard, Michel (author)
Nohr, Ellen Aagaard (author)
Ntalla, Ioanna (author)
Oken, Emily (author)
Panoutsopoulou, Kalliope (author)
Pararajasingham, Jennifer (author)
Rodriguez, Alina (author)
Mittuniversitetet,Institutionen för samhällsvetenskap (-2013)
Salem, Rany M. (author)
Sebert, Sylvain (author)
Siitonen, Niina (author)
Strachan, David P. (author)
Teo, Yik-Ying (author)
Valcarcel, Beatriz (author)
Willemsen, Gonneke (author)
Zeggini, Eleftheria (author)
Boomsma, Dorret I. (author)
Cooper, Cyrus (author)
Gillman, Matthew (author)
Hocher, Berthold (author)
Lakka, Timo A. (author)
Mohlke, Karen L. (author)
Dedoussis, George V. (author)
Ong, Ken K. (author)
Pearson, Ewan R. (author)
Price, Thomas S. (author)
Power, Chris (author)
Raitakari, Olli T. (author)
Saw, Seang-Mei (author)
Scherag, Andre (author)
Simell, Olli (author)
Sorensen, Thorkild I. A. (author)
Wilson, James F. (author)
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 (creator_code:org_t)
2012-04-15
2012
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:5, s. 539-544
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 x 10(-8)) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 x 10(-11)), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 x 10(-12)), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 x 10(-3) for 6q22 and 1.2 x 10(-3) for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Keyword

aged; article; brain size; cephalometry; chromosome 17q; chromosome 17q21; chromosome 6q; chromosome 6q22; female; gene locus; genetic association; genetic variability; human; male; priority journal

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Ikram, M. Arfan
Fornage, Myriam
Smith, Albert V.
Seshadri, Sudha
Schmidt, Reinhol ...
Debette, Stephan ...
show more...
Vrooman, Henri A ...
Sigurdsson, Sigu ...
Ropele, Stefan
Taal, H. Rob
Mook-Kanamori, D ...
Coker, Laura H.
Longstreth, W. T ...
Niessen, Wiro J.
DeStefano, Anita ...
Beiser, Alexa
Zijdenbos, Alex ...
Struchalin, Maks ...
Jack, Clifford R ...
Rivadeneira, Fer ...
Uitterlinden, An ...
Knopman, David S ...
Hartikainen, Ann ...
Pennell, Craig E ...
Thiering, Elisab ...
Steegers, Eric A ...
Hakonarson, Hako ...
Heinrich, Joachi ...
Palmer, Lyle J.
Jarvelin, Marjo- ...
McCarthy, Mark I ...
Grant, Struan F. ...
St Pourcain, Bea ...
Timpson, Nichola ...
Smith, George Da ...
Sovio, Ulla
Nalls, Mike A.
Au, Rhoda
Hofman, Albert
Gudnason, Haukur
van der Lugt, Aa ...
Harris, Tamara B ...
Meeks, William M ...
Vernooij, Meike ...
van Buchem, Mark ...
Catellier, Diane
Jaddoe, Vincent ...
Gudnason, Vilmun ...
Windham, B. Gwen
Wolf, Philip A.
van Duijn, Corne ...
Mosley, Thomas H ...
Schmidt, Helena
Launer, Lenore J ...
Breteler, Moniqu ...
DeCarli, Charles
Adair, Linda S.
Ang, Wei
Atalay, Mustafa
vanBeijsterveldt ...
Bergen, Nienke
Benke, Kelly
Berry, Diane
Coin, Lachlan
Davis, Oliver S. ...
Elliott, Paul
Flexeder, Claudi ...
Frayling, Tim
Gaillard, Romy
Groen-Blokhuis, ...
Goh, Liang-Kee
Haworth, Claire ...
Hadley, Dexter
Hedebrand, Johan ...
Hinney, Anke
Hirschhorn, Joel ...
Holloway, John W ...
Holst, Claus
Hottenga, Jouke ...
Horikoshi, Momok ...
Huikari, Ville
Hypponen, Elina
Kilpelainen, Tuo ...
Kirin, Mirna
Kowgier, Matthew
Lakka, Hanna-Maa ...
Lange, Leslie A.
Lawlor, Debbie A ...
Lehtimaki, Terho
Lewin, Alex
Lindgren, Cecili ...
Lindi, Virpi
Maggi, Reedik
Marsh, Julie
Middeldorp, Chri ...
Millwood, Iona
Murray, Jeffrey ...
Nivard, Michel
Nohr, Ellen Aaga ...
Ntalla, Ioanna
Oken, Emily
Panoutsopoulou, ...
Pararajasingham, ...
Rodriguez, Alina
Salem, Rany M.
Sebert, Sylvain
Siitonen, Niina
Strachan, David ...
Teo, Yik-Ying
Valcarcel, Beatr ...
Willemsen, Gonne ...
Zeggini, Elefthe ...
Boomsma, Dorret ...
Cooper, Cyrus
Gillman, Matthew
Hocher, Berthold
Lakka, Timo A.
Mohlke, Karen L.
Dedoussis, Georg ...
Ong, Ken K.
Pearson, Ewan R.
Price, Thomas S.
Power, Chris
Raitakari, Olli ...
Saw, Seang-Mei
Scherag, Andre
Simell, Olli
Sorensen, Thorki ...
Wilson, James F.
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
Articles in the publication
Nature Genetics
By the university
Mid Sweden University

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