Sökning: WFRF:(O'Neill Terence W.) >
Association of hypo...
Association of hypogonadism with vitamin D status: the European Male Ageing Study
-
Lee, David M. (författare)
-
Tajar, Abdelouahid (författare)
-
Pye, Stephen R. (författare)
-
visa fler...
-
Boonen, Steven (författare)
-
Vanderschueren, Dirk (författare)
-
Bouillon, Roger (författare)
-
O'Neill, Terence W. (författare)
-
Bartfai, Gyorgy (författare)
-
Casanueva, Felipe F. (författare)
-
Finn, Joseph D. (författare)
-
Forti, Gianni (författare)
-
- Giwercman, Aleksander (författare)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
-
Han, Thang S. (författare)
-
Huhtaniemi, Ilpo T. (författare)
-
Kula, Krzysztof (författare)
-
Lean, Michael E. J. (författare)
-
Pendleton, Neil (författare)
-
Punab, Margus (författare)
-
Wu, Frederick C. W. (författare)
-
visa färre...
-
(creator_code:org_t)
- 2012
- 2012
- Engelska.
-
Ingår i: European Journal of Endocrinology. - 1479-683X. ; 166:1, s. 77-85
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective: Interrelationships between hormones of the hypothalamic-pituitary-testicular (HPT) axis, hypogonadism, vitamin D and seasonality remain poorly defined. We investigated whether HPT axis hormones and hypogonadism are associated with serum levels of 25-hydroxyvitamin D (25(OH)D) in men. Design and methods: Cross-sectional survey of 3369 community-dwelling men aged 40-79 years in eight European centres. Testosterone (T), oestradiol (E(2)) and dihydrotestosterone were measured by gas chromatography-mass spectrometry; LH, FSH, sex hormone binding globulin (SHBG), 25(OH)D and parathyroid hormone by immunoassay. Free T was calculated from total T, SHBG and albumin. Gonadal status was categorised as eugonadal (normal T/LH), secondary (low T, low/normal LH), primary (low T, elevated LH) and compensated (normal T, elevated LH) hypogonadism. Associations of HPT axis hormones with 25(OH)D were examined using linear regression and hypogonadism with vitamin D using multinomial logistic regression. Results: In univariate analyses, free T levels were lower (P=0.02) and E(2) and LH levels were higher (P<0.05) in men with vitamin D deficiency (25(OH)D <50 nmol/l). 25(OH)D was positively associated with total and free T and negatively with E(2) and LH in age- and centre-adjusted linear regressions. After adjusting for health and lifestyle factors, no significant associations were observed between 25(OH)D and individual hormones of the HPT axis. However, vitamin D deficiency was significantly associated with compensated (relative risk ratio (RRR)=1.52, P=0.03) and secondary hypogonadism (RRR=1.16, P=0.05). Seasonal variation was only observed for 25(OH)D (P<0.001). Conclusions: Secondary and compensated hypogonadism were associated with vitamin D deficiency and the clinical significance of this relationship warrants further investigation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Lee, David M.
-
Tajar, Abdelouah ...
-
Pye, Stephen R.
-
Boonen, Steven
-
Vanderschueren, ...
-
Bouillon, Roger
-
visa fler...
-
O'Neill, Terence ...
-
Bartfai, Gyorgy
-
Casanueva, Felip ...
-
Finn, Joseph D.
-
Forti, Gianni
-
Giwercman, Aleks ...
-
Han, Thang S.
-
Huhtaniemi, Ilpo ...
-
Kula, Krzysztof
-
Lean, Michael E. ...
-
Pendleton, Neil
-
Punab, Margus
-
Wu, Frederick C. ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
European Journal ...
- Av lärosätet
-
Lunds universitet