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Activation of mater...
Activation of maternal Epstein-Barr virus infection and risk of acute leukemia in the offspring
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Tedeschi, Rosamaria (författare)
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Bloigu, Aini (författare)
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Ogmundsdottir, Helga M. (författare)
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Marus, Alessia (författare)
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- Dillner, Joakim (författare)
- Karolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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dePaoli, Paolo (författare)
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Gudnadottir, Margret (författare)
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Koskela, Pentti (författare)
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Pukkala, Eero (författare)
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Lehtinen, Tuula (författare)
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Lehtinen, Matti (författare)
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(creator_code:org_t)
- 2006-09-27
- 2007
- Engelska.
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Ingår i: American Journal of Epidemiology. - : Oxford University Press (OUP). - 0002-9262 .- 1476-6256. ; 165:2, s. 134-137
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https://academic.oup...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- After identifying an association between maternal Epstein-Barr virus (EBV) reactivation and acute lymphoblastic leukemia (ALL), the authors analyzed a nested case-control study within Finnish and Icelandic maternity cohorts with 7 million years of follow-up to confirm EBV's role in ALL. Offspring of 550,000 mothers were followed up to age 15 years during 1975-1997 by national cancer registries to identify leukemia cases. Mothers of cases and three quarters of matched mothers of controls were identified by national population registers. First-trimester sera from mothers of 304 ALL cases and 39 non-ALL cases and from 943 mothers of controls were analyzed for antibodies to viral capsid antigen, early antigen, and EBV transactivator protein ZEBRA. Relative risk, estimated as odds ratio (95% confidence interval), was adjusted for birth order and sibship size. Combining early antigen and/or ZEBRA immunoglobulin G antibodies with the presence of viral capsid antigen immunoglobulin M antibodies did not increase the estimate for ALL risk for viral capsid antigen immunoglobulin M alone (odds ratio = 1.9, 95% confidence interval: 1.2, 3.0). Both ZEBRA immunoglobulin G antibodies and viral capsid antigen immunoglobulin M antibodies were associated with an increased risk of non-ALL in the offspring (odds ratio = 4.5, 95% confidence interval: 1.3, 16; odds ratio = 5.6, 95% confidence interval: 1.1, 29, respectively), suggesting EBV reactivation in the mothers of non-ALL cases. EBV reactivation may be associated with a proportion of childhood leukemia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- case-control studies
- antibodies
- child
- Epstein-Barr virus infections
- Iceland
- Finland
- leukemia
- lymphocytic
- acute
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Tedeschi, Rosama ...
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Bloigu, Aini
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Ogmundsdottir, H ...
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Marus, Alessia
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Dillner, Joakim
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dePaoli, Paolo
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visa fler...
-
Gudnadottir, Mar ...
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Koskela, Pentti
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Pukkala, Eero
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Lehtinen, Tuula
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Lehtinen, Matti
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visa färre...
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