Search: WFRF:(Olopade Olufunmilayo I.) >
Ancestry-shift refi...
Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus.
-
Stacey, Simon N (author)
-
Sulem, Patrick (author)
-
Zanon, Carlo (author)
-
show more...
-
Gudjonsson, Sigurjon A (author)
-
Thorleifsson, Gudmar (author)
-
Helgason, Agnar (author)
-
Jonasdottir, Aslaug (author)
-
Besenbacher, Soren (author)
-
Kostic, Jelena P (author)
-
Fackenthal, James D (author)
-
Huo, Dezheng (author)
-
Adebamowo, Clement (author)
-
Ogundiran, Temidayo (author)
-
Olson, Janet E (author)
-
Fredericksen, Zachary S (author)
-
Wang, Xianshu (author)
-
Look, Maxime P (author)
-
Sieuwerts, Anieta M (author)
-
Martens, John W M (author)
-
Pajares, Isabel (author)
-
Garcia-Prats, Maria D (author)
-
Ramon-Cajal, Jose M (author)
-
de Juan, Ana (author)
-
Panadero, Angeles (author)
-
Ortega, Eugenia (author)
-
Aben, Katja K H (author)
-
Vermeulen, Sita H (author)
-
Asadzadeh, Fatemeh (author)
-
van Engelenburg, K C Anton (author)
-
Margolin, Sara (author)
-
Shen, Chen-Yang (author)
-
Wu, Pei-Ei (author)
-
Försti, Asta (author)
-
Lenner, Per (author)
-
Henriksson, Roger (author)
-
Johansson, Robert (author)
-
Enquist, Kerstin (author)
-
Hallmans, Göran (author)
-
Jonsson, Thorvaldur (author)
-
Sigurdsson, Helgi (author)
-
Alexiusdottir, Kristin (author)
-
Gudmundsson, Julius (author)
-
Sigurdsson, Asgeir (author)
-
Frigge, Michael L (author)
-
Gudmundsson, Larus (author)
-
Kristjansson, Kristleifur (author)
-
Halldorsson, Bjarni V (author)
-
Styrkarsdottir, Unnur (author)
-
Gulcher, Jeffrey R (author)
-
Hemminki, Kari (author)
-
Lindblom, Annika (author)
-
Kiemeney, Lambertus A (author)
-
Mayordomo, Jose I (author)
-
Foekens, John A (author)
-
Couch, Fergus J (author)
-
Olopade, Olufunmilayo I (author)
-
Gudbjartsson, Daniel F (author)
-
Thorsteinsdottir, Unnur (author)
-
Rafnar, Thorunn (author)
-
Johannsson, Oskar T (author)
-
Stefansson, Kari (author)
-
show less...
-
(publisher)
-
(publisher)
- Public Library of Science 2010
- 2010
- English.
-
In: PLoS genetics. - 1553-7404. ; 6:7, e1001029
Abstract
Subject headings
Close
- We used an approach that we term ancestry-shift refinement mapping to investigate an association, originally discovered in a GWAS of a Chinese population, between rs2046210[T] and breast cancer susceptibility. The locus is on 6q25.1 in proximity to the C6orf97 and estrogen receptor alpha (ESR1) genes. We identified a panel of SNPs that are correlated with rs2046210 in Chinese, but not necessarily so in other ancestral populations, and genotyped them in breast cancer case:control samples of Asian, European, and African origin, a total of 10,176 cases and 13,286 controls. We found that rs2046210[T] does not confer substantial risk of breast cancer in Europeans and Africans (OR = 1.04, P = 0.099, and OR = 0.98, P = 0.77, respectively). Rather, in those ancestries, an association signal arises from a group of less common SNPs typified by rs9397435. The rs9397435[G] allele was found to confer risk of breast cancer in European (OR = 1.15, P = 1.2 x 10(-3)), African (OR = 1.35, P = 0.014), and Asian (OR = 1.23, P = 2.9 x 10(-4)) population samples. Combined over all ancestries, the OR was 1.19 (P = 3.9 x 10(-7)), was without significant heterogeneity between ancestries (P(het) = 0.36) and the SNP fully accounted for the association signal in each ancestry. Haplotypes bearing rs9397435[G] are well tagged by rs2046210[T] only in Asians. The rs9397435[G] allele showed associations with both estrogen receptor positive and estrogen receptor negative breast cancer. Using early-draft data from the 1,000 Genomes project, we found that the risk allele of a novel SNP (rs77275268), which is closely correlated with rs9397435, disrupts a partially methylated CpG sequence within a known CTCF binding site. These studies demonstrate that shifting the analysis among ancestral populations can provide valuable resolution in association mapping.
Subject headings
- Medical and Health Sciences (hsv)
- Medicin och hälsovetenskap (hsv)
- MEDICINE (svep)
- MEDICIN (svep)
Find in a library
To the university's database
- By the author/editor
-
Stacey, Simon N
-
Sulem, Patrick
-
Zanon, Carlo
-
Gudjonsson, Sigu ...
-
Thorleifsson, Gu ...
-
Helgason, Agnar
-
show more...
-
Jonasdottir, Asl ...
-
Besenbacher, Sor ...
-
Kostic, Jelena P
-
Fackenthal, Jame ...
-
Huo, Dezheng
-
Adebamowo, Cleme ...
-
Ogundiran, Temid ...
-
Olson, Janet E
-
Fredericksen, Za ...
-
Wang, Xianshu
-
Look, Maxime P
-
Sieuwerts, Aniet ...
-
Martens, John W ...
-
Pajares, Isabel
-
Garcia-Prats, Ma ...
-
Ramon-Cajal, Jos ...
-
de Juan, Ana
-
Panadero, Angele ...
-
Ortega, Eugenia
-
Aben, Katja K H
-
Vermeulen, Sita ...
-
Asadzadeh, Fatem ...
-
van Engelenburg, ...
-
Margolin, Sara
-
Shen, Chen-Yang
-
Wu, Pei-Ei
-
Försti, Asta
-
Lenner, Per
-
Henriksson, Roge ...
-
Johansson, Rober ...
-
Enquist, Kerstin
-
Hallmans, Göran
-
Jonsson, Thorval ...
-
Sigurdsson, Helg ...
-
Alexiusdottir, K ...
-
Gudmundsson, Jul ...
-
Sigurdsson, Asge ...
-
Frigge, Michael ...
-
Gudmundsson, Lar ...
-
Kristjansson, Kr ...
-
Halldorsson, Bja ...
-
Styrkarsdottir, ...
-
Gulcher, Jeffrey ...
-
Hemminki, Kari
-
Lindblom, Annika
-
Kiemeney, Lamber ...
-
Mayordomo, Jose ...
-
Foekens, John A
-
Couch, Fergus J
-
Olopade, Olufunm ...
-
Gudbjartsson, Da ...
-
Thorsteinsdottir ...
-
Rafnar, Thorunn
-
Johannsson, Oska ...
-
Stefansson, Kari
-
show less...
- By the university
-
Swepub_uni:_t