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Adjuvant capecitabi...
Adjuvant capecitabine-containing chemotherapy benefit and homologous recombination deficiency in early-stage triple-negative breast cancer patients
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- de Boo, Leonora W. (author)
- Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands
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- Jozwiak, Katarzyna (author)
- Brandenburg Med Sch Theodor Fontane, Inst Biostat & Registry Res, Neuruppin, Germany.;Netherlands Canc Inst, Dept Epidemiol & Biostat, Amsterdam, Netherlands
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- Joensuu, Heikki (author)
- Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland
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- Lindman, Henrik (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Lauttia, Susanna (author)
- Univ Helsinki, Lab Mol Oncol, Biomed Helsinki, Helsinki, Finland
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- Opdam, Mark (author)
- Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands
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- van Steenis, Charlaine (author)
- Netherlands Canc Inst, Genom Core Facil, Amsterdam, Netherlands
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- Brugman, Wim (author)
- Netherlands Canc Inst, Genom Core Facil, Amsterdam, Netherlands
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- Kluin, Roelof J. C. (author)
- Netherlands Canc Inst, Genom Core Facil, Amsterdam, Netherlands
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- Schouten, Philip C. (author)
- Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands
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- Kok, Marleen (author)
- Netherlands Canc Inst, Dept Med Oncol, Amsterdam, Netherlands.;Netherlands Canc Inst, Div Tumor Biol & Immunol, Amsterdam, Netherlands
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- Nederlof, Petra M. (author)
- Antoni van Leeuwenhoek Hosp, Dept Pathol, Netherlands Canc Inst, Amsterdam, Netherlands
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- Hauptmann, Michael (author)
- Brandenburg Med Sch Theodor Fontane, Inst Biostat & Registry Res, Neuruppin, Germany.;Netherlands Canc Inst, Dept Epidemiol & Biostat, Amsterdam, Netherlands
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- Linn, Sabine C. (author)
- Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands.;Netherlands Canc Inst, Dept Med Oncol, Amsterdam, Netherlands.;Univ Med Ctr, Dept Pathol, Utrecht, Netherlands
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Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands Brandenburg Med Sch Theodor Fontane, Inst Biostat & Registry Res, Neuruppin, Germany;Netherlands Canc Inst, Dept Epidemiol & Biostat, Amsterdam, Netherlands (creator_code:org_t)
- 2022-02-05
- 2022
- English.
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In: British Journal of Cancer. - : Springer Nature. - 0007-0920 .- 1532-1827. ; 126:10, s. 1401-1409
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Abstract
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- Background The addition of adjuvant capecitabine to standard chemotherapy of early-stage triple-negative breast cancer (TNBC) patients has improved survival in a few randomised trials and in meta-analyses. However, many patients did not benefit. We evaluated the BRCA1-like DNA copy number signature, indicative of homologous recombination deficiency, as a predictive biomarker for capecitabine benefit in the TNBC subgroup of the FinXX trial.Methods Early-stage TNBC patients were randomised between adjuvant capecitabine-containing (TX + CEX: capecitabine-docetaxel, followed by cyclophosphamide-epirubicin-capecitabine) and conventional chemotherapy (T + CEF: docetaxel, followed by cyclophosphamide-epirubicin-fluorouracil). Tumour BRCA1-like status was determined on low-coverage, whole genome next-generation sequencing data using an established DNA comparative genomic hybridisation algorithm.Results For 129/202 (63.9%) patients the BRCA1-like status could be determined, mostly due to lack of tissue. During a median follow-up of 10.7 years, 35 recurrences and 32 deaths occurred. Addition of capecitabine appears to improve recurrence-free survival more among 61 (47.3%) patients with non-BRCA1-like tumours (HR 0.23, 95% CI 0.08-0.70) compared to 68 (52.7%) patients with BRCA1-like tumours (HR 0.66, 95% CI 0.24-1.81) (P-interaction = 0.17).Conclusion Based on our data, patients with non-BRCA1-like TNBC appear to benefit from the addition of capecitabine to adjuvant chemotherapy. Patients with BRCA1-like TNBC may also benefit. Additional research is needed to define the subgroup within BRCA1-like TNBC patients who may not benefit from adjuvant capecitabine.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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de Boo, Leonora ...
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Jozwiak, Katarzy ...
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Joensuu, Heikki
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Lindman, Henrik
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Lauttia, Susanna
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Opdam, Mark
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van Steenis, Cha ...
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Brugman, Wim
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Kluin, Roelof J. ...
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Schouten, Philip ...
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Kok, Marleen
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Nederlof, Petra ...
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Hauptmann, Micha ...
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Linn, Sabine C.
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- MEDICAL AND HEALTH SCIENCES
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and Clinical Medicin ...
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British Journal ...
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Uppsala University