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Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

Machiela, Mitchell J (author)
Zhou, Weiyin (author)
Karlins, Eric (author)
show more...
Sampson, Joshua N (author)
Freedman, Neal D (author)
Yang, Qi (author)
Hicks, Belynda (author)
Dagnall, Casey (author)
Hautman, Christopher (author)
Jacobs, Kevin B (author)
Abnet, Christian C (author)
Aldrich, Melinda C (author)
Amos, Christopher (author)
Amundadottir, Laufey T (author)
Arslan, Alan A (author)
Beane-Freeman, Laura E (author)
Berndt, Sonja I (author)
Black, Amanda (author)
Blot, William J (author)
Bock, Cathryn H (author)
Bracci, Paige M (author)
Brinton, Louise A (author)
Bueno-de-Mesquita, H Bas (author)
Burdett, Laurie (author)
Buring, Julie E (author)
Butler, Mary A (author)
Canzian, Federico (author)
Carreón, Tania (author)
Chaffee, Kari G (author)
Chang, I-Shou (author)
Chatterjee, Nilanjan (author)
Chen, Chu (author)
Chen, Constance (author)
Chen, Kexin (author)
Chung, Charles C (author)
Cook, Linda S (author)
Crous Bou, Marta (author)
Cullen, Michael (author)
Davis, Faith G (author)
De Vivo, Immaculata (author)
Ding, Ti (author)
Doherty, Jennifer (author)
Duell, Eric J (author)
Epstein, Caroline G (author)
Fan, Jin-Hu (author)
Figueroa, Jonine D (author)
Fraumeni, Joseph F (author)
Friedenreich, Christine M (author)
Fuchs, Charles S (author)
Gallinger, Steven (author)
Gao, Yu-Tang (author)
Gapstur, Susan M (author)
Garcia-Closas, Montserrat (author)
Gaudet, Mia M (author)
Gaziano, J Michael (author)
Giles, Graham G (author)
Gillanders, Elizabeth M (author)
Giovannucci, Edward L (author)
Goldin, Lynn (author)
Goldstein, Alisa M (author)
Haiman, Christopher A (author)
Hallmans, Göran (author)
Umeå universitet,Näringsforskning
Hankinson, Susan E (author)
Harris, Curtis C (author)
Henriksson, Roger (author)
Umeå universitet,Onkologi
Holly, Elizabeth A (author)
Hong, Yun-Chul (author)
Hoover, Robert N (author)
Hsiung, Chao A (author)
Hu, Nan (author)
Hu, Wei (author)
Hunter, David J (author)
Hutchinson, Amy (author)
Jenab, Mazda (author)
Johansen, Christoffer (author)
Khaw, Kay-Tee (author)
Kim, Hee Nam (author)
Kim, Yeul Hong (author)
Kim, Young Tae (author)
Klein, Alison P (author)
Klein, Robert (author)
Koh, Woon-Puay (author)
Kolonel, Laurence N (author)
Kooperberg, Charles (author)
Kraft, Peter (author)
Krogh, Vittorio (author)
Kurtz, Robert C (author)
LaCroix, Andrea (author)
Lan, Qing (author)
Landi, Maria Teresa (author)
Marchand, Loic Le (author)
Li, Donghui (author)
Liang, Xiaolin (author)
Liao, Linda M (author)
Lin, Dongxin (author)
Liu, Jianjun (author)
Lissowska, Jolanta (author)
Lu, Lingeng (author)
Magliocco, Anthony M (author)
Malats, Nuria (author)
Matsuo, Keitaro (author)
McNeill, Lorna H (author)
McWilliams, Robert R (author)
Melin, Beatrice S (author)
Umeå universitet,Onkologi
Mirabello, Lisa (author)
Moore, Lee (author)
Olson, Sara H (author)
Orlow, Irene (author)
Park, Jae Yong (author)
Patiño-Garcia, Ana (author)
Peplonska, Beata (author)
Peters, Ulrike (author)
Petersen, Gloria M (author)
Pooler, Loreall (author)
Prescott, Jennifer (author)
Prokunina-Olsson, Ludmila (author)
Purdue, Mark P (author)
Qiao, You-Lin (author)
Rajaraman, Preetha (author)
Real, Francisco X (author)
Riboli, Elio (author)
Risch, Harvey A (author)
Rodriguez-Santiago, Benjamin (author)
Ruder, Avima M (author)
Savage, Sharon A (author)
Schumacher, Fredrick (author)
Schwartz, Ann G (author)
Schwartz, Kendra L (author)
Seow, Adeline (author)
Wendy Setiawan, Veronica (author)
Severi, Gianluca (author)
Shen, Hongbing (author)
Sheng, Xin (author)
Shin, Min-Ho (author)
Shu, Xiao-Ou (author)
Silverman, Debra T (author)
Spitz, Margaret R (author)
Stevens, Victoria L (author)
Stolzenberg-Solomon, Rachael (author)
Stram, Daniel (author)
Tang, Ze-Zhong (author)
Taylor, Philip R (author)
Teras, Lauren R (author)
Tobias, Geoffrey S (author)
Van Den Berg, David (author)
Visvanathan, Kala (author)
Wacholder, Sholom (author)
Wang, Jiu-Cun (author)
Wang, Zhaoming (author)
Wentzensen, Nicolas (author)
Wheeler, William (author)
White, Emily (author)
Wiencke, John K (author)
Wolpin, Brian M (author)
Wong, Maria Pik (author)
Wu, Chen (author)
Wu, Tangchun (author)
Wu, Xifeng (author)
Wu, Yi-Long (author)
Wunder, Jay S (author)
Xia, Lucy (author)
Yang, Hannah P (author)
Yang, Pan-Chyr (author)
Yu, Kai (author)
Zanetti, Krista A (author)
Zeleniuch-Jacquotte, Anne (author)
Zheng, Wei (author)
Zhou, Baosen (author)
Ziegler, Regina G (author)
Perez-Jurado, Luis A (author)
Caporaso, Neil E (author)
Rothman, Nathaniel (author)
Tucker, Margaret (author)
Dean, Michael C (author)
Yeager, Meredith (author)
Chanock, Stephen J (author)
show less...
 (creator_code:org_t)
2016-06-13
2016
English.
In: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 7
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events >2 Mb in 97 (0.25%) women. Here we show rates for X-chromosome mosaicism are four times higher than mean autosomal rates; X mosaic events more often include the entire chromosome and participants with X events more likely harbour autosomal mosaic events. X mosaicism frequency increases with age (0.11% in 50-year olds; 0.45% in 75-year olds), as reported for Y and autosomes. Methylation array analyses of 33 women with X mosaicism indicate events preferentially involve the inactive X chromosome. Our results provide further evidence that the sex chromosomes undergo mosaic events more frequently than autosomes, which could have implications for understanding the underlying mechanisms of mosaic events and their possible contribution to risk for chronic diseases.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

Biological sciences
Cancer
Genetics

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Machiela, Mitche ...
Zhou, Weiyin
Karlins, Eric
Sampson, Joshua ...
Freedman, Neal D
Yang, Qi
show more...
Hicks, Belynda
Dagnall, Casey
Hautman, Christo ...
Jacobs, Kevin B
Abnet, Christian ...
Aldrich, Melinda ...
Amos, Christophe ...
Amundadottir, La ...
Arslan, Alan A
Beane-Freeman, L ...
Berndt, Sonja I
Black, Amanda
Blot, William J
Bock, Cathryn H
Bracci, Paige M
Brinton, Louise ...
Bueno-de-Mesquit ...
Burdett, Laurie
Buring, Julie E
Butler, Mary A
Canzian, Federic ...
Carreón, Tania
Chaffee, Kari G
Chang, I-Shou
Chatterjee, Nila ...
Chen, Chu
Chen, Constance
Chen, Kexin
Chung, Charles C
Cook, Linda S
Crous Bou, Marta
Cullen, Michael
Davis, Faith G
De Vivo, Immacul ...
Ding, Ti
Doherty, Jennife ...
Duell, Eric J
Epstein, Carolin ...
Fan, Jin-Hu
Figueroa, Jonine ...
Fraumeni, Joseph ...
Friedenreich, Ch ...
Fuchs, Charles S
Gallinger, Steve ...
Gao, Yu-Tang
Gapstur, Susan M
Garcia-Closas, M ...
Gaudet, Mia M
Gaziano, J Micha ...
Giles, Graham G
Gillanders, Eliz ...
Giovannucci, Edw ...
Goldin, Lynn
Goldstein, Alisa ...
Haiman, Christop ...
Hallmans, Göran
Hankinson, Susan ...
Harris, Curtis C
Henriksson, Roge ...
Holly, Elizabeth ...
Hong, Yun-Chul
Hoover, Robert N
Hsiung, Chao A
Hu, Nan
Hu, Wei
Hunter, David J
Hutchinson, Amy
Jenab, Mazda
Johansen, Christ ...
Khaw, Kay-Tee
Kim, Hee Nam
Kim, Yeul Hong
Kim, Young Tae
Klein, Alison P
Klein, Robert
Koh, Woon-Puay
Kolonel, Laurenc ...
Kooperberg, Char ...
Kraft, Peter
Krogh, Vittorio
Kurtz, Robert C
LaCroix, Andrea
Lan, Qing
Landi, Maria Ter ...
Marchand, Loic L ...
Li, Donghui
Liang, Xiaolin
Liao, Linda M
Lin, Dongxin
Liu, Jianjun
Lissowska, Jolan ...
Lu, Lingeng
Magliocco, Antho ...
Malats, Nuria
Matsuo, Keitaro
McNeill, Lorna H
McWilliams, Robe ...
Melin, Beatrice ...
Mirabello, Lisa
Moore, Lee
Olson, Sara H
Orlow, Irene
Park, Jae Yong
Patiño-Garcia, A ...
Peplonska, Beata
Peters, Ulrike
Petersen, Gloria ...
Pooler, Loreall
Prescott, Jennif ...
Prokunina-Olsson ...
Purdue, Mark P
Qiao, You-Lin
Rajaraman, Preet ...
Real, Francisco ...
Riboli, Elio
Risch, Harvey A
Rodriguez-Santia ...
Ruder, Avima M
Savage, Sharon A
Schumacher, Fred ...
Schwartz, Ann G
Schwartz, Kendra ...
Seow, Adeline
Wendy Setiawan, ...
Severi, Gianluca
Shen, Hongbing
Sheng, Xin
Shin, Min-Ho
Shu, Xiao-Ou
Silverman, Debra ...
Spitz, Margaret ...
Stevens, Victori ...
Stolzenberg-Solo ...
Stram, Daniel
Tang, Ze-Zhong
Taylor, Philip R
Teras, Lauren R
Tobias, Geoffrey ...
Van Den Berg, Da ...
Visvanathan, Kal ...
Wacholder, Sholo ...
Wang, Jiu-Cun
Wang, Zhaoming
Wentzensen, Nico ...
Wheeler, William
White, Emily
Wiencke, John K
Wolpin, Brian M
Wong, Maria Pik
Wu, Chen
Wu, Tangchun
Wu, Xifeng
Wu, Yi-Long
Wunder, Jay S
Xia, Lucy
Yang, Hannah P
Yang, Pan-Chyr
Yu, Kai
Zanetti, Krista ...
Zeleniuch-Jacquo ...
Zheng, Wei
Zhou, Baosen
Ziegler, Regina ...
Perez-Jurado, Lu ...
Caporaso, Neil E
Rothman, Nathani ...
Tucker, Margaret
Dean, Michael C
Yeager, Meredith
Chanock, Stephen ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cancer and Oncol ...
Articles in the publication
Nature Communica ...
By the university
Umeå University

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