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Maternal and newbor...
Maternal and newborn plasma oxytocin levels in response to maternal synthetic oxytocin administration during labour, birth and postpartum : a systematic review with implications for the function of the oxytocinergic system
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- Buckley, Sarah (författare)
- Faculty of Medicine, The University of Queensland, Brisbane (AUS)
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- Uvnäs-Moberg, Kerstin (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjurens miljö och hälsa (HMH),Department of Animal Environment and Health,Swedish University of Agricultural Sciences, Uppsala (SWE)
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- Pajalic, Zada (författare)
- Faculty for Health Sciences, VID Specialized University, Oslo (NOR)
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- Luegmair, Karolina (författare)
- Institute for Health Care and Nursing Studies, Martin Luther University Halle-Wittenberg, Halle (DEU)
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- Ekström-Bergström, Anette, 1958- (författare)
- Högskolan Väst,Avdelningen för omvårdnad - avancerad nivå,LOVHH KAMAIL
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- Dencker, Anna, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för vårdvetenskap och hälsa,Institute of Health and Care Sciences,Institute of Health and Care Sciences, The Sahlgrenska Academy, University of Gothenburg, Göteborg (SWE)
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- Massarotti, Claudia (författare)
- Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa (ITA)
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- Kotlowska, Alicja (författare)
- Department of Clinical and Experimental Endocrinology, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk (POL)
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- Callaway, Leonie (författare)
- Faculty of Medicine, The University of Queensland, Brisbane (AUS)
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- Morano, Sandra (författare)
- Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa (ITA)
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- Olza, Ibone (författare)
- European Institute of Perinatal Mental Health, Madrid (ESP)
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- Magistretti, Claudia Meier (författare)
- Institute for Health Policies, Prevention and Health Promotion, Lucerne University of Applied Sciences and Arts, Luzern (CHE)
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(creator_code:org_t)
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- 2023-03-02
- 2023
- Engelska.
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Ingår i: BMC Pregnancy and Childbirth. - : Springer Science and Business Media LLC. - 1471-2393. ; 23:1
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The reproductive hormone oxytocin facilitates labour, birth and postpartum adaptations for women and newborns. Synthetic oxytocin is commonly given to induce or augment labour and to decrease postpartum bleeding.AIM: To systematically review studies measuring plasma oxytocin levels in women and newborns following maternal administration of synthetic oxytocin during labour, birth and/or postpartum and to consider possible impacts on endogenous oxytocin and related systems.METHODS: Systematic searches of PubMed, CINAHL, PsycInfo and Scopus databases followed PRISMA guidelines, including all peer-reviewed studies in languages understood by the authors. Thirty-five publications met inclusion criteria, including 1373 women and 148 newborns. Studies varied substantially in design and methodology, so classical meta-analysis was not possible. Therefore, results were categorized, analysed and summarised in text and tables.RESULTS: Infusions of synthetic oxytocin increased maternal plasma oxytocin levels dose-dependently; doubling the infusion rate approximately doubled oxytocin levels. Infusions below 10 milliunits per minute (mU/min) did not raise maternal oxytocin above the range observed in physiological labour. At high intrapartum infusion rates (up to 32 mU/min) maternal plasma oxytocin reached 2-3 times physiological levels. Postpartum synthetic oxytocin regimens used comparatively higher doses with shorter duration compared to labour, giving greater but transient maternal oxytocin elevations. Total postpartum dose was comparable to total intrapartum dose following vaginal birth, but post-caesarean dosages were higher. Newborn oxytocin levels were higher in the umbilical artery vs. umbilical vein, and both were higher than maternal plasma levels, implying substantial fetal oxytocin production in labour. Newborn oxytocin levels were not further elevated following maternal intrapartum synthetic oxytocin, suggesting that synthetic oxytocin at clinical doses does not cross from mother to fetus.CONCLUSIONS: Synthetic oxytocin infusion during labour increased maternal plasma oxytocin levels 2-3-fold at the highest doses and was not associated with neonatal plasma oxytocin elevations. Therefore, direct effects from synthetic oxytocin transfer to maternal brain or fetus are unlikely. However, infusions of synthetic oxytocin in labour change uterine contraction patterns. This may influence uterine blood flow and maternal autonomic nervous system activity, potentially harming the fetus and increasing maternal pain and stress.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
- SAMHÄLLSVETENSKAP -- Utbildningsvetenskap -- Lärande (hsv//swe)
- SOCIAL SCIENCES -- Educational Sciences -- Learning (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Augmentation of labour
- Induction of labour
- Maternal oxytocin
- Newborn oxytocin
- Oxytocin
- Pitocin
- Postpartum oxytocin
- Synthetic oxytocin
- Syntocinon
- Vårdvetenskap
- Nursing science
- Work Integrated Learning
- Arbetsintegrerat lärande
- Oxytocin
- Maternal oxytocin
- Newborn oxytocin
- Synthetic oxytocin
- Pitocin
- Syntocinon
- Postpartum oxytocin
- Induction of labour
- Augmentation of labour
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Buckley, Sarah
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Uvnäs-Moberg, Ke ...
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Pajalic, Zada
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Luegmair, Karoli ...
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Ekström-Bergströ ...
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Dencker, Anna, 1 ...
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Massarotti, Clau ...
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Kotlowska, Alicj ...
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Callaway, Leonie
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Morano, Sandra
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Olza, Ibone
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Magistretti, Cla ...
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och Omvårdnad
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SAMHÄLLSVETENSKA ...
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och Lärande
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- Av lärosätet
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Högskolan Väst
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Sveriges Lantbruksuniversitet
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Göteborgs universitet