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Do risk factors for...
Do risk factors for schizophrenia predispose to emigration?
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Pedersen, Carsten Bocker (författare)
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Mortensen, Preben Bo (författare)
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- Cantor-Graae, Elizabeth (författare)
- Lund University,Lunds universitet,Socialmedicin och global hälsa,Forskargrupper vid Lunds universitet,Social Medicine and Global Health,Lund University Research Groups
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- Engelska.
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Ingår i: Schizophrenia Research. - : Elsevier BV. - 0920-9964. ; 127:1-3, s. 229-234
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: Increased incidence rates of schizophrenia in immigrants still lack a satisfactory explanation. The aim of this study was to examine the hypothesis that risk factors for schizophrenia also increase the risk of emigration to a foreign country. If valid, Danes emigrating from Denmark carry a higher predisposition to develop schizophrenia compared to Danes living in Denmark. Methods: Utilizing data from the Danish Civil Registration System, we established a population-based cohort of 1.10 million native Danes. We assessed relative risks of emigration to a foreign country in relation to sex, age, urban birth, parental age, and a history of mental illness. Results: Urban birth in Denmark was a significant predictor of emigration to a foreign country. A maternal history of psychiatric contact during childhood and a parental history of bipolar affective disorder increased the risks of emigration. A personal history of mental illness decreased the risk of emigration, mostly for people diagnosed with schizophrenia. Conclusions: Our study provided evidence that Danish emigrants residing in a foreign country have both a higher predisposition of schizophrenia due to differential exposure to birth in urban areas and a lower predisposition of schizophrenia due to differential exposure to a history of mental illness. Although competing selection mechanisms operate, the combined effect of these different selection mechanisms was limited, thus suggesting a potential role for yet to be identified adverse environmental effects operating either before or after emigration. (C) 2011 Elsevier B.V. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Schizophrenia
- Bipolar affective disorder
- Emigration
- Denmark
- Epidemiology
- Risk factor
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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