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Serum proteomic pro...
Serum proteomic profiling at diagnosis predicts clinical course, and need for intensification of treatment in inflammatory bowel disease
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- Kalla, R. (författare)
- Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom; MRC Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, United Kingdom,Univ Edinburgh, Scotland; Univ Edinburgh, Scotland
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- Adams, A. T. (författare)
- Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom; Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom,Univ Edinburgh, Scotland; Univ Oxford, England
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- Bergemalm, Daniel, 1977- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology,Orebro Univ, Sweden
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- Vatn, S. (författare)
- Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway,Akershus Univ Hosp, Norway
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- Kennedy, N. A. (författare)
- Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom; Exeter IBD and Pharmacogenetics group, University of Exeter, United Kingdom,Univ Edinburgh, Scotland; Univ Exeter, England
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- Ricanek, P. (författare)
- Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway,Univ Edinburgh, Scotland; Univ Oslo, Norway
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- Lindstrom, J. (författare)
- Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway,Akershus Univ Hosp, Norway; Univ Oslo, Norway
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- Ocklind, A. (författare)
- Olink Proteomics, Uppsala, Sweden,Olink Prote, Sweden
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- Hjelm, F. (författare)
- Olink Proteomics, Uppsala, Sweden,Olink Prote, Sweden
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- Ventham, N. T. (författare)
- Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom,Univ Edinburgh, Scotland
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- Ho, G. T. (författare)
- MRC Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, United Kingdom,Univ Edinburgh, Scotland
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- Petren, C. (författare)
- Olink Proteomics, Uppsala, Sweden,Olink Prote, Sweden
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- Repsilber, Dirk, 1971- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden
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- Söderholm, Johan D (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US
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- Pierik, M. (författare)
- Maastricht University Medical Centre (MUMC), Department of Gastroenterology and Hepatology, Maastricht, Netherlands,Maastricht Univ Med Ctr MUMC, Netherlands
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- D'Amato, M. (författare)
- Biocruces Health Research Institute, Molecular Genetics of Digestive Diseases, Cruces, Bilbao, Spain; School of Biological Sciences, Monash University, Victoria, Australia,Basque Fdn Sci, Spain; Basque Fdn Sci, Spain; Monash Univ, Australia
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- Gomollón, F. (författare)
- HCU "Lozano Blesa," IIS Aragón, Zaragoza, Spain
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- Olbjorn, C. (författare)
- Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway,Akershus Univ Hosp, Norway; Univ Oslo, Norway
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- Jahnsen, J. (författare)
- Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway,Akershus Univ Hosp, Norway; Univ Oslo, Norway,Orebro Univ, Sweden,Univ Edinburgh, Scotland; Univ Oxford, England
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- Vatn, M. H. (författare)
- Department of Gastroenterology, Akershus UnInstitute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway,Univ Oslo, Norway
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- Halfvarson, Jonas, 1970- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology
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- Satsangi, J. (författare)
- Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom; Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
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(creator_code:org_t)
- 2020-11-17
- 2021
- Engelska.
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Ingår i: Journal of Crohn's & Colitis. - : Elsevier. - 1873-9946 .- 1876-4479. ; 15:5, s. 699-708
- Relaterad länk:
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https://www.ncbi.nlm...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Success in personalised medicine in complex disease is critically dependent on biomarker discovery. We profiled serum proteins using a novel proximity extension assay (PEA) to identify diagnostic and prognostic biomarkers in inflammatory bowel disease (IBD).METHODS: We conducted a prospective case-control study in an inception cohort of 552 patients (328 IBD, 224 non-IBD), profiling proteins recruited across 6 centres. Treatment escalation was characterised by the need for biological agents or surgery after initial disease remission. Nested leave-one-out cross validation was used to examine the performance of diagnostic and prognostic proteins.RESULTS: A total of 66 serum proteins differentiated IBD from symptomatic non-IBD controls including MMP-12 (Holm adjusted p=4.1×10 -23 ) and OSM (p=3.7×10 -16). Nine of these proteins associate with cis- germline variation (59 independent SNPs). Fifteen proteins, all members of TNF independent pathways including IL-1 and OSM predicted escalation, over a median follow-up of 518 (IQR 224-756) days. Nested cross-validation of the entire data set allows characterisation of 5-protein-models (96% comprising five core proteins ITGAV, EpCAM, IL18, SLAMF7, and IL8) which define a high-risk subgroup in IBD (HR 3.90, CI: 2.43-6.26), or allows distinct 2, and 3 protein models for UC and CD respectively.CONCLUSION: We have characterised a simple oligo-protein panel that has the potential to identify IBD from symptomatic controls and to predict future disease course. Further prospective work is required to validate our findings.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Crohn's disease
- OSM
- genetics
- inflammatory bowel diseases (IBD)
- outcomes
- prognosis
- protein quantitative trait loci
- proteins
- proximity extension assay
- ulcerative colitis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Kalla, R.
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Adams, A. T.
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Bergemalm, Danie ...
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Vatn, S.
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Kennedy, N. A.
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Ricanek, P.
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visa fler...
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Lindstrom, J.
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Ocklind, A.
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Hjelm, F.
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Ventham, N. T.
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Ho, G. T.
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Petren, C.
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Repsilber, Dirk, ...
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Söderholm, Johan ...
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Pierik, M.
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D'Amato, M.
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Gomollón, F.
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Olbjorn, C.
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Jahnsen, J.
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Vatn, M. H.
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Halfvarson, Jona ...
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Satsangi, J.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
- Artiklar i publikationen
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Journal of Crohn ...
- Av lärosätet
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Örebro universitet
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Linköpings universitet