Circulating high sensitivity C reactive protein concentrations and risk of lung cancer: nested case-control study within Lung Cancer Cohort Consortium

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Circulating high sensitivity C reactive protein concentrations and risk of lung cancer : nested case-control study within Lung Cancer Cohort Consortium

Muller, David C. (författare): International Agency for Research on Cancer, World Health Organization,Imperial College London

Larose, Tricia L. (författare): Norwegian University of Science and Technology,International Agency for Research on Cancer, World Health Organization

Hodge, Allison (författare): Cancer Council Victoria,University of Melbourne

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Guida, Florence (författare): International Agency for Research on Cancer, World Health Organization

Langhammer, Arnulf (författare): Norwegian University of Science and Technology

Grankvist, Kjell (författare): Umeå University,Umeå universitet,Klinisk kemi

Meyer, Klaus (författare): Bevital AS

Cai, Qiuyin (författare): Vanderbilt University

Arslan, Alan A. (författare): New York University,University of Arizona

Zeleniuch-Jacquotte, Anne (författare): New York University

Albanes, Demetrius (författare): National Cancer Institute, USA

Giles, Graham G. (författare): University of Melbourne,Cancer Council Victoria

Sesso, Howard D. (författare): Harvard University,Brigham and Women's Hospital / Harvard Medical School

Lee, I-Min (författare): Brigham and Women's Hospital / Harvard Medical School,Harvard University

Gaziano, J. Michael (författare): Umeå University

Yuan, Jian-Min (författare): University of Pittsburgh

Bolton, Judith Hoffman (författare): Johns Hopkins Bloomberg School of Public Health

Buring, Julie E. (författare): Harvard University,Brigham and Women's Hospital / Harvard Medical School

Visvanathan, Kala (författare): Johns Hopkins Bloomberg School of Public Health

Le Marchand, Loic (författare)

Purdue, Mark P. (författare): National Cancer Institute, USA,Fred Hutchinson Cancer Research Center

Caporaso, Neil E. (författare): National Cancer Institute, USA

Midttun, Oivind (författare): Bevital AS

Ueland, Per M. (författare): Haukeland University Hospital,University of Bergen

Prentice, Ross L. (författare): University of Bergen,Haukeland University Hospital

Weinstein, Stephanie J. (författare): National Cancer Institute, USA

Stevens, Victoria L. (författare): American Cancer Society

Zheng, Wei (författare): Vanderbilt University

Blot, William J. (författare): Vanderbilt University

Shu, Xiao-Ou (författare): Vanderbilt University

Zhang, Xuehong (författare): Brigham and Women's Hospital / Harvard Medical School

Xiang, Yong-Bing (författare): Renji Hospital

Koh, Woon-Puay (författare): Duke–NUS Medical School

Hveem, Kristian (författare): Italian Institute for Genomic Medicine (IIGM)

Thomson, Cynthia A. (författare)

Pettinger, Mary (författare)

Engström, Gunnar (författare): Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups

Brunnström, Hans (författare): Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,Region Skåne

Milne, Roger L. (författare): University of Melbourne,Cancer Council Victoria

Stampfer, Meir J. (författare): Harvard University,Brigham and Women's Hospital / Harvard Medical School

Han, Jiali (författare)

Johansson, Mikael (författare): Umeå universitet,Onkologi

Brennan, Paul (författare): International Agency for Research on Cancer, World Health Organization

Severi, Gianluca (författare): Cancer Council Victoria,Versailles Saint-Quentin-en-Yvelines University

Johansson, Mattias (författare): International Agency for Research on Cancer, World Health Organization

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(creator_code:org_t)

2019-01-03
2019
Engelska.
Ingår i: The BMJ. - : BMJ Publishing Group Ltd. - 1756-1833 .- 0959-8138. ; 364

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://www.bmj.com/...; http://dx.doi.org/10... (free); https://urn.kb.se/re...; https://doi.org/10.1...; https://lup.lub.lu.s...; visa färre...

Tidskriftsartikel (refereegranskat)

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Objectives To conduct a comprehensive analysis of prospectively measured circulating high sensitivity C reactive protein (hsCRP) concentration and risk of lung cancer overall, by smoking status (never, former, and current smokers), and histological sub-type.Design Nested case-control study.Setting 20 population based cohort studies in Asia, Europe, Australia, and the United States.Participants 5299 patients with incident lung cancer, with individually incidence density matched controls.Exposure Circulating hsCRP concentrations in prediagnostic serum or plasma samples.Main outcome measure Incident lung cancer diagnosis.Results A positive association between circulating hsCRP concentration and the risk of lung cancer for current (odds ratio associated with a doubling in hsCRP concentration 1.09, 95% confidence interval 1.05 to 1.13) and former smokers (1.09, 1.04 to 1.14) was observed, but not for never smokers (P<0.01 for interaction). This association was strong and consistent across all histological subtypes, except for adenocarcinoma, which was not strongly associated with hsCRP concentration regardless of smoking status (odds ratio for adenocarcinoma overall 0.97, 95% confidence interval 0.94 to 1.01). The association between circulating hsCRP concentration and the risk of lung cancer was strongest in the first two years of follow-up for former and current smokers. Including hsCRP concentration in a risk model, in addition to smoking based variables, did not improve risk discrimination overall, but slightly improved discrimination for cancers diagnosed in the first two years of follow-up.Conclusions Former and current smokers with higher circulating hsCRP concentrations had a higher risk of lung cancer overall. Circulating hsCRP concentration was not associated with the risk of lung adenocarcinoma. Circulating hsCRP concentration could be a prediagnostic marker of lung cancer rather than a causal risk factor.

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Av författaren/redakt...: Muller, David C.; Larose, Tricia L ...; Hodge, Allison; Guida, Florence; Langhammer, Arnu ...; Grankvist, Kjell; visa fler...; Meyer, Klaus; Cai, Qiuyin; Arslan, Alan A.; Zeleniuch-Jacquo ...; Albanes, Demetri ...; Giles, Graham G.; Sesso, Howard D.; Lee, I-Min; Gaziano, J. Mich ...; Yuan, Jian-Min; Bolton, Judith H ...; Buring, Julie E.; Visvanathan, Kal ...; Le Marchand, Loi ...; Purdue, Mark P.; Caporaso, Neil E ...; Midttun, Oivind; Ueland, Per M.; Prentice, Ross L ...; Weinstein, Steph ...; Stevens, Victori ...; Zheng, Wei; Blot, William J.; Shu, Xiao-Ou; Zhang, Xuehong; Xiang, Yong-Bing; Koh, Woon-Puay; Hveem, Kristian; Thomson, Cynthia ...; Pettinger, Mary; Engström, Gunnar; Brunnström, Hans; Milne, Roger L.; Stampfer, Meir J ...; Han, Jiali; Johansson, Mikae ...; Brennan, Paul; Severi, Gianluca; Johansson, Matti ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: The BMJ; BMJ

Av lärosätet: Umeå universitet; Lunds universitet

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Circulating high sensitivity C reactive protein concentrations and risk of lung cancer : nested case-control study within Lung Cancer Cohort Consortium

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