Sökning: WFRF:(Peyratout G) >
Blood DNA methylomi...
Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer's disease in the EMIF-AD study
-
- Smith, Rebecca G. (författare)
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Devon, UK
-
- Pishva, Ehsan (författare)
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Devon, UK; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands
-
- Kouhsar, Morteza (författare)
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Devon, UK
-
visa fler...
-
- Imm, Jennifer (författare)
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Devon, UK
-
- Dobricic, Valerija (författare)
- Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany
-
- Johannsen, Peter (författare)
- Danish Dementia Research Centre, Rigshospitalet, Copenhagen, Denmark
-
- Wittig, Michael (författare)
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany
-
- Franke, Andre (författare)
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany
-
- Vandenberghe, Rik (författare)
- Laboratory for Cognitive Neurology, KU Leuven, Leuven Brain Institute, Leuven, Belgium
-
- Schaeverbeke, Jolien (författare)
- Laboratory for Cognitive Neurology, KU Leuven, Leuven Brain Institute, Leuven, Belgium
-
- Freund-Levi, Yvonne, 1956- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden; Department of Geriatrics, Södertälje Hospital, Södertälje, Sweden
-
- Frölich, Lutz (författare)
- Department of Geriatric Psychiatry, Central Institut of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany
-
- Scheltens, Philip (författare)
- Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
-
- Teunissen, Charlotte E. (författare)
- Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
-
- Frisoni, Giovanni (författare)
- Memory center, Geneva University and University Hospitals; AMYPAD consortium, Geneva, Switzerland
-
- Blin, Olivier (författare)
- Aix-Marseille University-CNRS, Marseille, France
-
- Richardson, Jill C. (författare)
- Neuroscience Therapeutic Area, GlaxoSmithKline R&D, Stevenage, Hertfordshire, UK
-
- Bordet, Régis (författare)
- Université de Lille, Lille, Cedex, France
-
- Engelborghs, Sebastiaan (författare)
- Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium; Neuroprotection & Neuromodulation (NEUR) Research Group, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Jette, Brussels, Belgium
-
- de Roeck, Ellen (författare)
- Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
-
- Martinez-Lage, Pablo (författare)
- Center for Research and Advanced Therapies, Fundación CITA-Alzhéimer Fundazioa, San Sebastian, Gipuzkoa, Spain
-
- Altuna, Miren (författare)
- Center for Research and Advanced Therapies, Fundación CITA-Alzhéimer Fundazioa, San Sebastian, Gipuzkoa, Spain
-
- Tainta, Mikel (författare)
- Center for Research and Advanced Therapies, Fundación CITA-Alzhéimer Fundazioa, San Sebastian, Gipuzkoa, Spain
-
- Lleó, Alberto (författare)
- Servicio de Neurología, Centre of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Hospital Sant Pau, Barcelona, Spain
-
- Sala, Isabel (författare)
- Servicio de Neurología, Centre of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Hospital Sant Pau, Barcelona, Spain
-
- Popp, Julius (författare)
- University Hospital of Psychiatry Zürich, University of Zürich, Zürich, Switzerland
-
- Peyratout, Gwendoline (författare)
- Department of Psychiatry, University Hospital of Lausanne (CHUV), Lausanne, Switzerland
-
- Winchester, Laura (författare)
- Department of Psychiatry, University of Oxford, Oxford, UK
-
- Nevado-Holgado, Alejo (författare)
- Department of Psychiatry, University of Oxford, Oxford, UK
-
- Verhey, Frans (författare)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands
-
- Tsolaki, Magda (författare)
- 1st Department of Neurology, School of Medicine, Laboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation, Aristotle University of Thessaloniki, and Alzheimer Hellas, Thessaloniki, Greece
-
- Andreasson, Ulf, 1968 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
- Streffer, Johannes (författare)
- Translational Medicine Neuroscience, UCB Biopharma SRL, Brussels, Belgium
-
- Vos, Stephanie J. B. (författare)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands
-
- Lovestone, Simon (författare)
- Department of Psychiatry, University Hospital of Lausanne (CHUV), Lausanne, Switzerland; Johnson & Johnson Innovative Medicines, Beerse, Belgium
-
- Visser, Pieter Jelle (författare)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
-
- Bertram, Lars (författare)
- Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany
-
- Lunnon, Katie (författare)
- Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Devon, UK
-
visa färre...
-
(creator_code:org_t)
- 2024
- 2024
- Engelska.
-
Ingår i: Alzheimer's & Dementia. - : John Wiley & Sons. - 1552-5260 .- 1552-5279.
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://gup.ub.gu.se...
-
visa färre...
Abstract
Ämnesord
Stäng
- INTRODUCTION: We investigated blood DNA methylation patterns associated with 15 well-established cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) pathophysiology, neuroinflammation, and neurodegeneration.METHODS: We assessed DNA methylation in 885 blood samples from the European Medical Information Framework for Alzheimer's Disease (EMIF-AD) study using the EPIC array.RESULTS: We identified Bonferroni-significant differential methylation associated with CSF YKL-40 (five loci) and neurofilament light chain (NfL; seven loci) levels, with two of the loci associated with CSF YKL-40 levels correlating with plasma YKL-40 levels. A co-localization analysis showed shared genetic variants underlying YKL-40 DNA methylation and CSF protein levels, with evidence that DNA methylation mediates the association between genotype and protein levels. Weighted gene correlation network analysis identified two modules of co-methylated loci correlated with several amyloid measures and enriched in pathways associated with lipoproteins and development.DISCUSSION: We conducted the most comprehensive epigenome-wide association study (EWAS) of AD-relevant CSF biomarkers to date. Future work should explore the relationship between YKL-40 genotype, DNA methylation, and protein levels in the brain.HIGHLIGHTS: Blood DNA methylation was assessed in the EMIF-AD MBD study. Epigenome-wide association studies (EWASs) were performed for 15 Alzheimer's disease (AD)-relevant cerebrospinal fluid (CSF) biomarker measures. Five Bonferroni-significant loci were associated with YKL-40 levels and seven with neurofilament light chain (NfL). DNA methylation in YKL-40 co-localized with previously reported genetic variation. DNA methylation potentially mediates the effect of single-nucleotide polymorphisms (SNPs) in YKL-40 on CSF protein levels.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimer's disease (AD)
- DNA methylation
- YKL‐40
- amyloid
- biomarker
- blood
- cerebrospinal fluid (CSF)
- epigenetics
- epigenome‐wide association study (EWAS)
- genome‐wide association study (GWAS)
- methylation quantitative trait loci (mQTL)
- mild cognitive impairment (MCI)
- neurofilament light (NfL)
- protein quantitative trait loci (pQTL)
- tau
- Alzheimer's disease (AD)
- amyloid
- biomarker
- blood
- cerebrospinal fluid (CSF)
- DNA methylation
- epigenetics
- epigenome-wide association study (EWAS)
- genome-wide association study (GWAS)
- methylation quantitative trait loci (mQTL)
- mild cognitive impairment (MCI)
- neurofilament light (NfL)
- protein quantitative trait loci (pQTL)
- tau
- YKL-40
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Smith, Rebecca G ...
-
Pishva, Ehsan
-
Kouhsar, Morteza
-
Imm, Jennifer
-
Dobricic, Valeri ...
-
Johannsen, Peter
-
visa fler...
-
Wittig, Michael
-
Franke, Andre
-
Vandenberghe, Ri ...
-
Schaeverbeke, Jo ...
-
Freund-Levi, Yvo ...
-
Frölich, Lutz
-
Scheltens, Phili ...
-
Teunissen, Charl ...
-
Frisoni, Giovann ...
-
Blin, Olivier
-
Richardson, Jill ...
-
Bordet, Régis
-
Engelborghs, Seb ...
-
de Roeck, Ellen
-
Martinez-Lage, P ...
-
Altuna, Miren
-
Tainta, Mikel
-
Lleó, Alberto
-
Sala, Isabel
-
Popp, Julius
-
Peyratout, Gwend ...
-
Winchester, Laur ...
-
Nevado-Holgado, ...
-
Verhey, Frans
-
Tsolaki, Magda
-
Andreasson, Ulf, ...
-
Blennow, Kaj, 19 ...
-
Zetterberg, Henr ...
-
Streffer, Johann ...
-
Vos, Stephanie J ...
-
Lovestone, Simon
-
Visser, Pieter J ...
-
Bertram, Lars
-
Lunnon, Katie
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Neurovetenskaper
- Artiklar i publikationen
-
Alzheimer's & De ...
- Av lärosätet
-
Örebro universitet
-
Göteborgs universitet