Apolipoprotein E ε4 genotype and the temporal relationship between depression and dementia

• To investigate how apolipoprotein E (. APOE) affects the temporal relationship between depression and dementia, we conducted a nested case-control study with longitudinal depression and dementia evaluations from several population studies by using 804 dementia cases and 1600 matched controls, totaling 1519 unique individuals. Depression within 10 years of onset of dementia was strongly associated with dementia diagnosis regardless of APOE status (incidence rate ratio [IRR] 5.25, 95% confidence interval [95% CI] 3.32-8.31 for ε4 carriers, IRR 4.40, 95%CI 3.23-5.99 for noncarriers). However, we found a significant interaction between depression more than 10 years before the onset of dementia and APOE (. p= 0.01), with depression more distal to dementia being a risk factor only in ε4 carriers (IRR 3.39, 95% CI 1.69-6.78 for carriers, IRR 1.01, 95% CI 0.60-1.70 for noncarriers). Thus, depression with onset close in time to dementia onset is associated with disease irrespective of APOE genotype, whereas depression more distal to dementia onset is a risk factor only in ε4-carriers. This is the first study to show the interaction between APOE and depression to be dependent on timing of depression onset.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Alzheimer disease

Apolipoprotein e

Dementia

Depression

apolipoprotein E4

adult

aged

Article

case control study

controlled study

disease association

female

gene interaction

genetic risk

genotype

heterozygote

human

incidence

major clinical study

male

onset age

priority journal

genetic association study

genetics

longitudinal study

risk factor

time factor

very elderly

Aged

80 and over

Case-Control Studies

Genetic Association Studies

Humans

Longitudinal Studies

Risk Factors

Time Factors

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)