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Shortened telomere ...
Shortened telomere length is associated with increased risk of cancer : a meta-analysis
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Ma, Hongxia (author)
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Zhou, Ziyuan (author)
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Wei, Sheng (author)
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Liu, Zhensheng (author)
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Pooley, Karen A (author)
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Dunning, Alison M (author)
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- Svenson, Ulrika (author)
- Umeå universitet,Patologi
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- Roos, Göran (author)
- Umeå universitet,Patologi
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Hosgood, H Dean (author)
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Shen, Min (author)
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Wei, Qingyi (author)
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(creator_code:org_t)
- 2011-06-10
- 2011
- English.
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In: PLOS ONE. - San Francisco : Public Library of Science. - 1932-6203. ; 6:6, s. e20466-
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https://umu.diva-por... (primary) (Raw object)
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https://journals.plo...
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Abstract
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- BACKGROUND: Telomeres play a key role in the maintenance of chromosome integrity and stability, and telomere shortening is involved in initiation and progression of malignancies. A series of epidemiological studies have examined the association between shortened telomeres and risk of cancers, but the findings remain conflicting.METHODS: A dataset composed of 11,255 cases and 13,101 controls from 21 publications was included in a meta-analysis to evaluate the association between overall cancer risk or cancer-specific risk and the relative telomere length. Heterogeneity among studies and their publication bias were further assessed by the χ(2)-based Q statistic test and Egger's test, respectively.RESULTS: The results showed that shorter telomeres were significantly associated with cancer risk (OR = 1.35, 95% CI = 1.14-1.60), compared with longer telomeres. In the stratified analysis by tumor type, the association remained significant in subgroups of bladder cancer (OR = 1.84, 95% CI = 1.38-2.44), lung cancer (OR = 2.39, 95% CI = 1.18-4.88), smoking-related cancers (OR = 2.25, 95% CI = 1.83-2.78), cancers in the digestive system (OR = 1.69, 95% CI = 1.53-1.87) and the urogenital system (OR = 1.73, 95% CI = 1.12-2.67). Furthermore, the results also indicated that the association between the relative telomere length and overall cancer risk was statistically significant in studies of Caucasian subjects, Asian subjects, retrospective designs, hospital-based controls and smaller sample sizes. Funnel plot and Egger's test suggested that there was no publication bias in the current meta-analysis (P = 0.532).CONCLUSIONS: The results of this meta-analysis suggest that the presence of shortened telomeres may be a marker for susceptibility to human cancer, but single larger, well-design prospective studies are warranted to confirm these findings.
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PLOS ONE
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- By the author/editor
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Ma, Hongxia
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Zhou, Ziyuan
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Wei, Sheng
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Liu, Zhensheng
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Pooley, Karen A
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Dunning, Alison ...
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show more...
-
Svenson, Ulrika
-
Roos, Göran
-
Hosgood, H Dean
-
Shen, Min
-
Wei, Qingyi
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show less...
- Articles in the publication
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PLOS ONE
- By the university
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Umeå University