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Sökning: onr:"swepub:oai:DiVA.org:uu-327230" > Outcomes after Umbi...

Outcomes after Umbilical Cord Blood Transplantation for Myelodysplastic Syndromes

Gerds, Aaron T. (författare)
Cleveland Clin, Taussig Canc Inst, Hematol & Med Oncol, Cleveland, OH 44106 USA.
Ahn, Kwang Woo (författare)
Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA.
Hu, Zhen-Huan (författare)
Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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Abdel-Azim, Hisham (författare)
Univ Southern Calif, Keck Sch Med, Childrens Hosp Angeles, Div Hematol Oncol & Blood & Marrow Transplantat, Los Angeles, CA 90033 USA.
Akpek, Gorgun (författare)
Rush Univ, Med Ctr, Dept Internal Med, Stem Cell Transplantat & Cell Therapy, Chicago, IL 60612 USA.
Aljurf, Mahmoud (författare)
King Faisal Specialist Hosp & Res Ctr, Dept Oncol, Riyadh, Saudi Arabia.
Ballen, Karen K. (författare)
Massachusetts Gen Hosp, Dept Hematol Oncol, Boston, MA 02114 USA.
Beitinjaneh, Amer (författare)
Univ Miami, Div Hematol & Oncol, Miami, FL USA.
Bacher, Ulrike (författare)
Inselspital Bern, Dept Hematol, Bern, Switzerland.;Univ Canc Ctr Hamburg, Interdisciplinary Clin Stem Cell Transplantat, Hamburg, Germany.
Cahn, Jean-Yves (författare)
Univ Hosp, Dept Hematol, Grenoble, France.
Chhabra, Saurabh (författare)
Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
Cutler, Corey (författare)
Dana Farber Canc Inst, Ctr Hematol Oncol, Boston, MA 02115 USA.
Daly, Andrew (författare)
Tom Baker Canc Clin, Calgary, AB, Canada.
DeFilipp, Zachariah (författare)
Massachusetts Gen Hosp, Dept Hematol Oncol, Boston, MA 02114 USA.
Gale, Robert Peter (författare)
Imperial Coll London, Dept Med, Div Expt Med, Hematol Res Ctr, London, England.
Gergis, Usama (författare)
New York Presbyterian Hosp, Weill Cornell Med Ctr, Dept Med Oncol, Hematolg Malignancies & Bone Marrow Transplant, New York, NY USA.
Grunwald, Michael R. (författare)
Levine Canc Inst, Charlotte, NC USA.
Hale, Gregory A. (författare)
Johns Hopkins All Childrens Hosp, Dept Hematol Oncol, St Petersburg, FL USA.
Hamilton, Betty Ky (författare)
Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA.
Jagasia, Madan (författare)
Vanderbilt Univ, Med Ctr, Div Hematol Oncol, 221 Kirkland Hall, Nashville, TN 37235 USA.
Kamble, Rammurti T. (författare)
Baylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX 77030 USA.
Kindwall-Keller, Tamila (författare)
Univ Virginia Hlth Syst, Div Hematol Oncol, Charlottesville, VA USA.
Nishihori, Taiga (författare)
H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA.
Olsson, Richard F. (författare)
Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Div Therapeut Immunol, Stockholm, Sweden.
Ramanathan, Muthalagu (författare)
UMass Mem Med Ctr, Dept Med, Div Hematol & Oncol, Worcester, MA USA.
Saad, Ayman A. (författare)
Univ Alabama Birmingham, Dept Med, Div Hematol Oncol, Birmingham, AL 35294 USA.
Solh, Melhem (författare)
Northside Hosp, Blood & Marrow Transplant Grp Georgia, Atlanta, GA USA.
Ustun, Celalettin (författare)
Univ Minnesota, Med Ctr, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA.
Valcarcel, David (författare)
Hosp Valle De Hebron, Dept Hematol, Barcelona, Spain.
Warlick, Erica (författare)
Univ Minnesota, Med Ctr, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA.
Wirk, Baldeep M. (författare)
Seattle Canc Care Alliance, Div Bone Marrow Transplant, Seattle, WA USA.
Kalaycio, Matt (författare)
Cleveland Clin, Taussig Canc Inst, Hematol & Med Oncol, Cleveland, OH 44106 USA.
Alyea, Edwin (författare)
Dana Farber Canc Inst, Ctr Hematol Oncol, Boston, MA 02115 USA.
Popat, Uday (författare)
MD Anderson Canc Ctr, Houston, TX USA.
Sobecks, Ronald (författare)
Cleveland Clin, Taussig Canc Inst, Hematol & Med Oncol, Cleveland, OH 44106 USA.
Saber, Wael (författare)
Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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Cleveland Clin, Taussig Canc Inst, Hematol & Med Oncol, Cleveland, OH 44106 USA Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA. (creator_code:org_t)
Elsevier, 2017
2017
Engelska.
Ingår i: Biology of blood and marrow transplantation. - : Elsevier. - 1083-8791 .- 1523-6536. ; 23:6, s. 971-979
Relaterad länk:
http://www.bbmt.org/...
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https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • For patients with hematologic malignancies undergoing allogeneic hematopoietic cell transplantation, umbilical cord blood transplantation (UCBT) has become an acceptable alternative donor source in the absence of a matched sibling or unrelated donor. To date, however, there have been few published series dedicated solely to describing the outcomes of adult patients with myelodysplastic syndrome (MDS) who have undergone UCBT. Between 2004 and 2013, 176 adults with MDS underwent UCBT as reported to the Center for International Blood and Marrow Transplant Research. Median age at the time of transplantation was 56 years (range, 18-73 years). The study group included 10% with very low, 23% with low, 19% with intermediate, 19% with high, and 13% with very high-risk Revised International Prognostic Scoring System (IPSS-R) scores. The 100-day probability of grade II-IV acute graft-versus-host disease (GVHD) was 38%, and the 3-year probability of chronic GVHD was 28%. The probabilities of relapse and transplantation-related mortality (TRM) at 3 years were 32% and 40%, respectively, leading to a 3-year disease-free survival (DFS) of 28% and an overall survival (OS) of 31%. In multivariate analysis, increasing IPSS-R score at the time of HCT was associated with inferior TRM (P = .0056), DFS (P = .018), and OS (P = .0082), but not with GVHD or relapse. The presence of pretransplantation comorbidities was associated with TRM (P = .001), DFS (P = .02), and OS (P = .001). Reduced intensity conditioning was associated with increased risk of relapse (relative risk, 3.95; 95% confidence interval, 1.78-8.75; P < .001), and although a higher proportion of myeloablative UCBTs were performed in patients with high-risk disease, the effect of conditioning regimen intensity was the same regardless of IPSS-R score. For some individuals who lack a matched sibling or unrelated donor, UCBT can result in long-term DFS; however, the success of UCBT in this population is hampered by a high rate of TRM. (C) 2017 American Society for Blood and Marrow Transplantation.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

Nyckelord

Umbilical cord transplantation
Blood and marrow transplantation
Myelodysplastic syndrome

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