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Genome-wide mapping...
Genome-wide mapping of promoter-anchored interactions with close to single-enhancer resolution
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- Sahlén, Pelin (författare)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Abdullayev, Ilgar (författare)
- Karolinska Institutet
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- Ramsköld, Daniel (författare)
- Karolinska Institutet
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- Matskova, Liudmila (författare)
- Karolinska Institutet
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- Rilakovic, Nemanja (författare)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Lötstedt, Britta (författare)
- KTH,Science for Life Laboratory, SciLifeLab
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Albert, Thomas J. (författare)
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- Lundeberg, Joakim (författare)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Sandberg, Rickard (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2015-08-03
- 2015
- Engelska.
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Ingår i: Genome Biology. - : Springer Science and Business Media LLC. - 1465-6906 .- 1474-760X. ; 16
- Relaterad länk:
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https://genomebiolog...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Although the locations of promoters and enhancers have been identified in several cell types, we still have limited information on their connectivity. We developed HiCap, which combines a 4-cutter restriction enzyme Hi-C with sequence capture of promoter regions. Applying the method to mouse embryonic stem cells, we identified promoter-anchored interactions involving 15,905 promoters and 71,984 distal regions. The distal regions were enriched for enhancer marks and transcription, and had a mean fragment size of only 699 bp - close to single-enhancer resolution. High-resolution maps of promoter-anchored interactions with HiCap will be important for detailed characterizations of chromatin interaction landscapes.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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