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Association of subc...
Association of subclinical inflammation with deterioration of glycaemia before the diagnosis of type 2 diabetes : the KORA S4/F4 study
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Klüppelholz, Birgit (author)
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Thorand, Barbara (author)
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Koenig, Wolfgang (author)
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Gala, Tonia de las Heras (author)
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Meisinger, Christa (author)
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Huth, Cornelia (author)
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Giani, Guido (author)
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- Franks, Paul W. (author)
- Umeå University,Lund University,Lunds universitet,Umeå universitet,Medicin,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University
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Roden, Michael (author)
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Rathmann, Wolfgang (author)
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Peters, Annette (author)
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Herder, Christian (author)
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(creator_code:org_t)
- 2015-07-09
- 2015
- English.
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In: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 58:10, s. 2269-2277
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https://link.springe...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Aims/hypothesis The role of biomarkers of subclinical inflammation in the early deterioration of glycaemia before type 2 diabetes is largely unknown. We hypothesised that increased levels of circulating proinflammatory biomarkers and decreased circulating adiponectin would be associated with 7 year increases of HbA1c in non-diabetic individuals.Methods This study was based on individuals who participated in the prospective Cooperative Health Research in the Region of Augsburg (KORA) S4 survey (1999–2001) and the 7 year follow-up KORA F4 (2006–2008) survey. Individuals with type 2 diabetes at baseline or with a diagnosis of diabetes in the period between both surveys were excluded, which left a sample of 850 men and women. Multivariable linear regression analyses were performed to assess associations among baseline values of leucocyte count and levels of acute-phase proteins (high-sensitivity C-reactive protein [hsCRP], serum amyloid A [SAA] and fibrinogen), IL-6 and adiponectin with changes in HbA1c between baseline and follow-up.Results A high leucocyte count and high hsCRP, SAA and IL-6 levels were positively associated with changes in HbA1c after adjusting for age, sex, lifestyle factors and baseline HbA1c. In contrast, the adiponectin level was inversely associated with changes in HbA1c (p value between <0.0001 and 0.020). The associations of leucocyte count and levels of hsCRP and SAA with HbA1c changes remained significant after additional adjustment for waist circumference and circulating lipids at baseline and for the 7 year change in waist circumference (p value between 0.004 and 0.045).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Adiponectin
- Cohort study
- Cytokines
- Glycaemia
- HbA(1c)
- Inflammation
- Type 2 diabetes
- Adiponectin
- Cohort study
- Cytokines
- Glycaemia
- HbA(1c)
- Inflammation
- Type 2 diabetes
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Klüppelholz, Bir ...
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Thorand, Barbara
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Koenig, Wolfgang
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Gala, Tonia de l ...
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Meisinger, Chris ...
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Huth, Cornelia
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show more...
-
Giani, Guido
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Franks, Paul W.
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Roden, Michael
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Rathmann, Wolfga ...
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Peters, Annette
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Herder, Christia ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetologia
- By the university
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Umeå University
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Lund University