Folding and design of helical repeat proteins / Lynne Regan.

• Contents: Repeat proteins versus globular proteins -- Consensus design, the role of conserved hydrophobic residues -- Co-variation can modulate stability, but is not essential to specify a stable fold -- Structure and stability of the designed CTPR proteins -- The thermodynamic behavior of repeat proteins in terms of a 1D Ising model -- Amide H-exchange to study stability on a residue specific basis -- The structure of long TPRs -- Hypervariability defines the ligand binding site: a general result -- Functional TPR designs -- Useful designer proteins -- The awesome power of screens and selections.

Ämnesord

Protein Conformation.  (MeSH)

Protein Folding.  (MeSH)

Proteins.  (MeSH)