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Safety and immunogenicity of a combined DTPa-IPV vaccine administered as a booster from 4 years of age : a review

Jacquet, J M (author)
GlaxoSmithKline Biologicals, Rixensart, Belgium
Bégué, P (author)
Hôpital d’enfants Armand Trousseau, Paris, France
Grimprel, E (author)
Hôpital d’enfants Armand Trousseau, Paris, France
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Reinert, P (author)
Hôpital Intercommunal de Créteil, France
Sandbu, S (author)
Norwegian Institute of Public Health, Oslo, Norway
Silfverdal, S A (author)
Umeå universitet,Pediatrik
Faldella, G (author)
Universita di Bologna, Italy
Nolan, T (author)
Murdoch Children's Research Institute, and the School of Population Health at the University of Melbourne, Parkville, Australia
Lambert, S (author)
Murdoch Children's Research Institute, and the School of Population Health at the University of Melbourne, Parkville, Australia
Richmond, P (author)
University of Western Australia, Perth, Australia
Marshall, H (author)
University of Adelaide, North Adelaide, Australia
Roberton, D (author)
University of Adelaide, North Adelaide, Australia
Schuerman, L (author)
GlaxoSmithKline Biologicals, Rixensart, Belgium
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 (creator_code:org_t)
Elsevier BV, 2006
2006
English.
In: Vaccine. - : Elsevier BV. - 0264-410X .- 1873-2518. ; 24:13, s. 2440-2448
Related links:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • A combined DTPa-IPV booster vaccine was administered as a 4th or 5th dose after DTPa or DTPw priming. Over 99% vaccines developed antibody levels considered to be protective to diphtheria, tetanus and poliovirus, and >95% mounted a response to acellular pertussis antigens. Rectal temperature >39.5 degrees C was observed in at most 3.2% of vaccinees. Swelling >50 mm occurred in 24% of DTPa-primed compared to 5.5% of DTPw-primed children. Large swelling involving the entire upper arm (extending to involve the elbow joint) was reported for up to 1.2% of DTPa-primed subjects, which is consistent with literature reports for other DTPa vaccines.

Keyword

Immunogenicity; Vaccine-associated adverse events; Acellular pertussis vaccine; Booster vaccination

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