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Sökning: onr:"swepub:oai:DiVA.org:uu-463320" > Multicenter evaluat...

Multicenter evaluation of parametric response mapping as an indicator of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation

Cheng, Guang‐Shing (författare)
Clinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington
Selwa, Katherine E. (författare)
University of Michigan Medical School Ann Arbor Michigan
Hatt, Charles (författare)
Imbio, LLC Minneapolis Minneapolis Minnesota
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Ram, Sundaresh (författare)
Department of Radiology Michigan Medicine Ann Arbor Michigan
Fortuna, Aleksa B. (författare)
Department of Radiology Michigan Medicine Ann Arbor Michigan
Guerriero, Margaret (författare)
Seattle Cancer Care Alliance Seattle Washington
Himelhoch, Ben (författare)
Michigan State University College of Human Medicine Lansing Michigan
McAree, Daniel (författare)
Pediatrics University of Michigan Ann Arbor Michigan
Hoffman, Timothy C. (författare)
University of Michigan Medical School Ann Arbor Michigan
Brisson, Joseph (författare)
Blood and Marrow Transplant Program Michigan Medicine Ann Arbor Michigan
Nazareno, Ryan (författare)
Blood and Marrow Transplant Program Michigan Medicine Ann Arbor Michigan
Bloye, Kiernan (författare)
Blood and Marrow Transplant Program Michigan Medicine Ann Arbor Michigan
Johnson, Timothy D. (författare)
Department of Biostatistics University of Michigan School of Public Health Ann Arbor Michigan
Remberger, Mats, Professor, 1955- (författare)
Uppsala universitet,Hematologi,Department of Oncology‐Pathology Karolinska University Hospital Stockholm Sweden
Mattsson, Jonas (författare)
Karolinska Institutet
Vummidi, Dharshan (författare)
Department of Radiology Michigan Medicine Ann Arbor Michigan
Kazerooni, Ella E. (författare)
Department of Radiology Michigan Medicine Ann Arbor Michigan
Lama, Vibha N. (författare)
Division of Pulmonary and Critical Care Medicine Michigan Medicine Ann Arbor Michigan
Galban, Stefanie (författare)
Department of Radiology Michigan Medicine Ann Arbor Michigan
Boeckh, Michael (författare)
Clinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington
Yanik, Gregory A. (författare)
Blood and Marrow Transplant Program Michigan Medicine Ann Arbor Michigan
Galban, Craig J. (författare)
Department of Radiology Michigan Medicine Ann Arbor Michigan
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 (creator_code:org_t)
Wiley, 2020
2020
Engelska.
Ingår i: American Journal of Transplantation. - : Wiley. - 1600-6135 .- 1600-6143. ; 20:8, s. 2198-2205
Relaterad länk:
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Parametric response mapping (PRM) is a novel computed tomography (CT) technology that has shown potential for assessment of bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HCT). The primary aim of this study was to evaluate whether variations in image acquisition under real-world conditions affect the PRM measurements of clinically diagnosed BOS. CT scans were obtained retrospectively from 72 HCT recipients with BOS and graft-versus-host disease from Fred Hutchinson Cancer Research Center, Karolinska Institute, and the University of Michigan. Whole lung volumetric scans were performed at inspiration and expiration using site-specific acquisition and reconstruction protocols. PRM and pulmonary function measurements were assessed. Patients with moderately severe BOS at diagnosis (median forced expiratory volume at 1 second [FEV1] 53.5% predicted) had similar characteristics between sites. Variations in site-specific CT acquisition protocols had a negligible effect on the PRM-derived small airways disease (SAD), that is, BOS measurements. PRM-derived SAD was found to correlate with FEV1% predicted and FEV1/ forced vital capacity (R = −0.236, P = .046; and R = −0.689, P < .0001, respectively), which suggests that elevated levels in the PRM measurements are primarily affected by BOS airflow obstruction and not CT scan acquisition parameters. Based on these results, PRM may be applied broadly for post-HCT diagnosis and monitoring of BOS.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

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