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25(OH)D Levels in I...
25(OH)D Levels in Infancy Is Associated With Celiac Disease Autoimmunity in At-Risk Children : A Case–Control Study
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- Andrén Aronsson, Carin (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Liu, Xiang (author)
- University of South Florida
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- Norris, Jill M. (author)
- Colorado School of Public Health
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- Uusitalo, Ulla (author)
- University of South Florida
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- Butterworth, Martha D. (author)
- University of South Florida
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- Koletzko, Sibylle (author)
- University Hospital Munich,University of Warmia and Mazury
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- Virtanen, Suvi M. (author)
- University of Tampere,Finnish National Institute for Health and Welfare
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- Erlund, Iris (author)
- Finnish National Institute for Health and Welfare
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- Kurppa, Kalle (author)
- University of Tampere,South Ostrobothnia Central Hospital,Tampere University Hospital
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- Hagopian, William A. (author)
- Pacific Northwest Research Institute
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- Rewers, Marian J. (author)
- Barbara Davis Center for Childhood Diabetes
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- She, Jin Xiong (author)
- Medical College of Georgia
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- Toppari, Jorma (author)
- Turku University Hospital,University of Turku
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- Ziegler, Anette G. (author)
- Klinikum rechts der Isar
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- Akolkar, Beena (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Krischer, Jeffrey P. (author)
- University of South Florida
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- Agardh, Daniel (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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(creator_code:org_t)
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- 2021-08-11
- 2021
- English.
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In: Frontiers in Nutrition. - : Frontiers Media SA. - 2296-861X. ; 8
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Abstract
Subject headings
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- Objectives: An observed variation in the risk of celiac disease, according to the season of birth, suggests that vitamin D may affect the development of the disease. The aim of this study was to investigate if vitamin D concentration is associated with the risk of celiac disease autoimmunity (CDA) in genetically at-risk children. Study Design: Children prospectively followed in the multinational The Environmental Determinants of Diabetes in the Young study, conducted at six centers in Europe and the US, were selected for a 1-to-3 nested case–control study. In total, 281 case–control sets were identified. CDA was defined as positivity for tissue transglutaminase autoantibodies (tTGA) on two or more consecutive visits. Vitamin D was measured as 25-hydroxyvitamin D [25(OH)D] concentrations in all plasma samples prior to, and including, the first tTGA positive visit. Conditional logistic regression was used to examine the association between 25(OH)D and risk of CDA. Results: No significant association was seen between 25(OH)D concentrations (per 5 nmol/L increase) and risk for CDA development during early infancy (odds ratio [OR] 0.99, 95% confidence interval [CI] 0.95–1.04) or childhood (OR 1.02, 95% CI 0.97–1.07). When categorizing 25(OH)D concentrations, there was an increased risk of CDA with 25(OH)D concentrations <30 nmol/L (OR 2.23, 95% CI 1.29, 3.84) and >75 nmol/L (OR 2.10, 95% CI 1.28–3.44) in early infancy, as compared with 50–75 nmol/L. Conclusion: This study indicates that 25(OH)D concentrations <30 nmol/L and >75 nmol/L during early infancy were associated with an increased risk of developing CDA in genetically at-risk children. The non-linear relationship raises the need for more studies on the possible role of 25(OH)D in the relation to celiac disease onset.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- celiac disease
- celiac disease autoimmunity
- children
- infants
- TEDDY
- vitamin D
Publication and Content Type
- art (subject category)
- ref (subject category)
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Andrén Aronsson, ...
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Liu, Xiang
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Norris, Jill M.
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Uusitalo, Ulla
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Butterworth, Mar ...
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Koletzko, Sibyll ...
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Virtanen, Suvi M ...
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Erlund, Iris
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Kurppa, Kalle
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Hagopian, Willia ...
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Rewers, Marian J ...
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She, Jin Xiong
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Toppari, Jorma
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Ziegler, Anette ...
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Akolkar, Beena
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Krischer, Jeffre ...
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Agardh, Daniel
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Frontiers in Nut ...
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Lund University