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Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

de las Fuentes, Lisa (författare)
Cardiovascular Division, Department of Medicine, Washington University, MO, St. Louis, United States; Division of Biostatistics, Washington University School of Medicine, MO, St. Louis, United States
Sung, Yun Ju (författare)
Division of Biostatistics, Washington University School of Medicine, MO, St. Louis, United States
Noordam, Raymond (författare)
Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, Netherlands
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Winkler, Thomas (författare)
Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany
Feitosa, Mary F. (författare)
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, MO, St. Louis, United States
Schwander, Karen (författare)
Division of Biostatistics, Washington University School of Medicine, MO, St. Louis, United States
Bentley, Amy R. (författare)
Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, MD, Bethesda, United States
Brown, Michael R. (författare)
Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, TX, Houston, United States
Guo, Xiuqing (författare)
The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, CA, Torrance, United States
Manning, Alisa (författare)
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, MA, Boston, United States; Department of Medicine, Harvard Medical School, MA, Boston, United States
Chasman, Daniel I. (författare)
Division of Preventive Medicine, Brigham and Women’s Hospital, MA, Boston, United States; Harvard Medical School, MA, Boston, United States
Aschard, Hugues (författare)
Department of Epidemiology, Harvard School of Public Health, MA, Boston, United States; Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur, Paris, France
Bartz, Traci M. (författare)
Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, WA, Seattle, United States
Bielak, Lawrence F. (författare)
Department of Epidemiology, School of Public Health, University of Michigan, MI, Ann Arbor, United States
Campbell, Archie (författare)
Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
Cheng, Ching-Yu (författare)
Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Ecy Centre, Singapore, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore
Dorajoo, Rajkumar (författare)
Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore
Hartwig, Fernando P. (författare)
Postgraduate Programme in Epidemiology, Federal University of Pelotas, RS, Pelotas, Brazil; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom
Horimoto, A.R.V.R. (författare)
Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, SP, São Paulo, Brazil
Li, Changwei (författare)
Epidemiology and Biostatistics, University of Georgia at Athens College of Public Health, GA, Athens, United States
Li-Gao, Ruifang (författare)
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Liu, Yongmei (författare)
Public Health Sciences, Epidemiology and Prevention, Wake Forest University Health Sciences, NC, Winston-Salem, United States
Marten, Jonathan (författare)
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
Musani, Solomon K. (författare)
Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, MS, Jackson, United States
Ntalla, Ioanna (författare)
Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
Rankinen, Tuomo (författare)
Human Genomics Laboratory, Pennington Biomedical Research Center, LA, Baton Rouge, United States
Richard, Melissa (författare)
Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, TX, Houston, United States
Sim, Xueling (författare)
Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore
Smith, Albert V. (författare)
Department of Biostatistics, University of Michigan, MI, Ann Arbor, United States; Icelandic Heart Association, Kopavogur, Iceland
Tajuddin, Salman M. (författare)
Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, MD, Baltimore, United States
Tayo, Bamidele O. (författare)
Department of Public Health Sciences, Loyola University Chicago, IL, Maywood, United States
Vojinovic, Dina (författare)
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands
Warren, Helen R. (författare)
Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, London, United Kingdom
Xuan, Deng (författare)
Biostatistics, Boston University School of Public Health, MA, Boston, United States
Alver, Maris (författare)
Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia; Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
Boissel, Mathilde (författare)
CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France
Chai, Jin-Fang (författare)
Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore
Chen, Xu (författare)
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden
Christensen, Kaare (författare)
Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, Southern Denmark University, Odense, Denmark
Divers, Jasmin (författare)
Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, NC, Winston-Salem, United States
Evangelou, Evangelos (författare)
Karolinska Institutet
Gao, Chuan (författare)
Molecular Genetics and Genomics Program, Wake Forest School of Medicine, NC, Winston-Salem, United States
Girotto, Giorgia (författare)
Medical Genetics, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy; Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”, Trieste, Italy
Harris, Sarah E. (författare)
Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom
He, Meian (författare)
Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Hsu, Fang-Chi (författare)
Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, NC, Winston-Salem, United States
Kühnel, Brigitte (författare)
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Laguzzi, Federica (författare)
Karolinska Institutet
Li, Xiaoyin (författare)
Department of Population and Quantitative Health Sciences, Case Western Reserve University, OH, Cleveland, United States; Department of Mathematics and Statistics, University of Minnesota, MN, Duluth, United States
Lyytikäinen, Leo-Pekka (författare)
Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, University of Tampere, Tampere, Finland
Nolte, Ilja M. (författare)
University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, Netherlands
Poveda, Alaitz (författare)
Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital
Rauramaa, Rainer (författare)
Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
Riaz, Muhammad (författare)
College of Medicine, Biological Sciences and Psychology, Health Sciences, The Infant Mortality and Morbidity Studies (TIMMS), Leicester, United Kingdom
Rueedi, Rico (författare)
Department of Computational Biology, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland
Shu, Xiao-ou (författare)
Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, TN, Nashville, United States
Snieder, Harold (författare)
University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, Netherlands
Sofer, Tamar (författare)
Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, MA, Boston, United States
Takeuchi, Fumihiko (författare)
Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
Verweij, Niek (författare)
University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, Netherlands
Ware, Erin B. (författare)
Survey Research Center, Institute for Social Research, University of Michigan, MI, Ann Arbor, United States
Weiss, Stefan (författare)
Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Health), Partner Site Greifswald, Greifswald, Germany
Yanek, Lisa R. (författare)
Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, United States
Amin, Najaf (författare)
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands
Arking, Dan E. (författare)
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, United States
Arnett, Donna K. (författare)
Dean’s Office, University of Kentucky College of Public Health, KY, Lexington, United States
Bergmann, Sven (författare)
Department of Computational Biology, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland
Boerwinkle, Eric (författare)
Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, TX, Houston, United States; Human Genome Sequencing Center, Baylor College of Medicine, TX, Houston, United States
Brody, Jennifer A. (författare)
Cardiovascular Health Research Unit, Medicine, University of Washington, WA, Seattle, United States
Broeckel, Ulrich (författare)
Section of Genomic Pediatrics, Department of Pediatrics, Medicine and Physiology, Medical College of Wisconsin, WI, Milwaukee, United States
Brumat, Marco (författare)
Medical Genetics, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy
Burke, Gregory (författare)
Public Health Sciences, Wake Forest School of Medicine, NC, Winston-Salem, United States
Cabrera, Claudia P. (författare)
Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, London, United Kingdom
Canouil, Mickaël (författare)
CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France
Chee, Miao Li (författare)
Statistics Unit, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
Chen, Yii-Der Ida (författare)
The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, CA, Torrance, United States
Cocca, Massimiliano (författare)
Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”, Trieste, Italy
Connell, John (författare)
Ninewells Hospital & Medical School, University of Dundee, Dundee, United Kingdom
de Silva, H. Janaka (författare)
Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka
de Vries, Paul S. (författare)
Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, TX, Houston, United States
Eiriksdottir, Gudny (författare)
Icelandic Heart Association, Kopavogur, Iceland
Faul, Jessica D. (författare)
Survey Research Center, Institute for Social Research, University of Michigan, MI, Ann Arbor, United States
Fisher, Virginia (författare)
Biostatistics, Boston University School of Public Health, MA, Boston, United States
Forrester, Terrence (författare)
Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Jamaica
Fox, Ervin F. (författare)
Cardiology, Medicine, University of Mississippi Medical Center, MS, Jackson, United States
Friedlander, Yechiel (författare)
Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel
Gao, He (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; MRC-PHE Centre for Environment and Health, Imperial College London, London, United Kingdom
Gigante, Bruna (författare)
Karolinska Institutet
Giulianini, Franco (författare)
Brigham and Women’s Hospital, MA, Boston, United States
Gu, Chi Charles (författare)
Division of Biostatistics, Washington University School of Medicine, MO, St. Louis, United States
Gu, Dongfeng (författare)
Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Harris, Tamara B. (författare)
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, MD, Bethesda, United States
He, Jiang (författare)
Epidemiology, Tulane University School of Public Health and Tropical Medicine, LA, New Orleans, United States; Medicine, Tulane University School of Medicine, LA, New Orleans, United States
Heikkinen, Sami (författare)
Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland
Heng, Chew-Kiat (författare)
Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Khoo Teck Puat – National University Children’s Medical Institute, National University Health System, Singapore, Singapore
Hunt, Steven (författare)
Cardiovascular Genetics, Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States; Weill Cornell Medicine in Qatar, Doha, Qatar
Ikram, M. Arfan (författare)
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, Netherlands
Irvin, Marguerite R. (författare)
Department of Biostatistics, University of Alabama at Birmingham, AL, Birmingham, United States
Kähönen, Mika (författare)
Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland; Department of Clinical Physiology, Finnish Cardiovascular Research Center–Tampere, Faculty of Medicine and Health Technology, University of Tampere, Tampere, Finland
Kavousi, Maryam (författare)
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands
Khor, Chiea Chuen (författare)
Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore; Department of Biochemistry, National University of Singapore, Singapore, Singapore
Kilpeläinen, Tuomas O. (författare)
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, NY, New York, United States
Koh, Woon-Puay (författare)
Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore; Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore
Komulainen, Pirjo (författare)
Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
Kraja, Aldi T. (författare)
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, MO, St. Louis, United States
Krieger, J.E. (författare)
Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, SP, São Paulo, Brazil
Langefeld, Carl D. (författare)
Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, NC, Winston-Salem, United States
Li, Yize (författare)
Division of Biostatistics, Washington University School of Medicine, MO, St. Louis, United States
Liang, Jingjing (författare)
Department of Population and Quantitative Health Sciences, Case Western Reserve University, OH, Cleveland, United States
Liewald, David C. M. (författare)
Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom
Liu, Ching-Ti (författare)
Biostatistics, Boston University School of Public Health, MA, Boston, United States
Liu, Jianjun (författare)
Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore
Lohman, Kurt K. (författare)
Public Health Sciences, Biostatistics and Data Science, Wake Forest University Health Sciences, NC, Winston-Salem, United States
Mägi, Reedik (författare)
Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
McKenzie, Colin A. (författare)
Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Jamaica
Meitinger, Thomas (författare)
Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Human Genetics, Technische Universität München, Munich, Germany
Metspalu, Andres (författare)
Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia; Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
Milaneschi, Yuri (författare)
Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, Netherlands
Milani, Lili (författare)
Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
Mook-Kanamori, Dennis O. (författare)
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands
Nalls, Mike A. (författare)
Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, MD, Bethesda, United States; Data Tecnica International, MD, Glen Echo, United States
Nelson, Christopher P. (författare)
Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom
Norris, Jill M. (författare)
Department of Epidemiology, University of Colorado Denver, CO, Aurora, United States
O’Connell, Jeff (författare)
Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, MD, Baltimore, United States; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, MD, Baltimore, United States
Ogunniyi, Adesola (författare)
Department of Medicine, University of Ibadan, Oyo, Ibadan, Nigeria
Padmanabhan, Sandosh (författare)
British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Palmer, Nicholette D. (författare)
Biochemistry, Wake Forest School of Medicine, NC, Winston-Salem, United States
Pedersen, Nancy L. (författare)
Karolinska Institutet
Perls, Thomas (författare)
Department of Medicine, Geriatrics Section, Boston Medical Center, Boston University School of Medicine, MA, Boston, United States
Peters, Annette (författare)
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Neuherberg, Germany
Petersmann, Astrid (författare)
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
Peyser, Patricia A. (författare)
Department of Epidemiology, School of Public Health, University of Michigan, MI, Ann Arbor, United States
Polasek, Ozren (författare)
University of Split School of Medicine, Split, Croatia; University Hospital Split, Split, Croatia; Psychiatric Hospital “Sveti Ivan”, Zagreb, Croatia
Porteous, David J. (författare)
Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom; Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom
Raffel, Leslie J. (författare)
Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California, CA, Irvine, United States
Rice, Treva K. (författare)
Division of Biostatistics, Washington University School of Medicine, MO, St. Louis, United States
Rotter, Jerome I. (författare)
The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, CA, Torrance, United States
Rudan, Igor (författare)
Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom
Rueda-Ochoa, Oscar-Leonel (författare)
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands
Sabanayagam, Charumathi (författare)
Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Ecy Centre, Singapore, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore
Salako, Babatunde L. (författare)
Department of Medicine, University of Ibadan, Oyo, Ibadan, Nigeria
Schreiner, Pamela J. (författare)
Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, MN, Minneapolis, United States
Shikany, James M. (författare)
Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, AL, Birmingham, United States
Sidney, Stephen S. (författare)
Division of Research, Kaiser Permanente of Northern California, CA, Oakland, United States
Sims, Mario (författare)
Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, MS, Jackson, United States
Sitlani, Colleen M. (författare)
Cardiovascular Health Research Unit, Medicine, University of Washington, WA, Seattle, United States
Smith, Jennifer A. (författare)
Department of Epidemiology, School of Public Health, University of Michigan, MI, Ann Arbor, United States; Survey Research Center, Institute for Social Research, University of Michigan, MI, Ann Arbor, United States
Starr, John M. (författare)
Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom
Strauch, Konstantin (författare)
Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Medical Informatics Biometry and Epidemiology, Ludwig-Maximilians-Universitat Munchen, Munich, Germany
Swertz, Morris A. (författare)
University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, Netherlands
Teumer, Alexander (författare)
DZHK (German Centre for Cardiovascular Health), Partner Site Greifswald, Greifswald, Germany; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
Tham, Yih Chung (författare)
Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Ecy Centre, Singapore, Singapore
Uitterlinden, André G. (författare)
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands
Vaidya, Dhananjay (författare)
Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, United States
van der Ende, M. Yldau (författare)
University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, Netherlands
Waldenberger, Melanie (författare)
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Neuherberg, Germany
Wang, Lihua (författare)
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, MO, St. Louis, United States
Wang, Ya-Xing (författare)
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China
Wei, Wen-Bin (författare)
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China
Weir, David R. (författare)
Survey Research Center, Institute for Social Research, University of Michigan, MI, Ann Arbor, United States
Wen, Wanqing (författare)
Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, TN, Nashville, United States
Yao, Jie (författare)
The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, CA, Torrance, United States
Yu, Bing (författare)
Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, TX, Houston, United States
Yu, Caizheng (författare)
Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Yuan, Jian-Min (författare)
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer, , University of Pittsburgh, PA, Pittsburgh, United States
Zhao, Wei (författare)
Department of Epidemiology, School of Public Health, University of Michigan, MI, Ann Arbor, United States
Zonderman, Alan B. (författare)
Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, MD, Baltimore, United States
Becker, Diane M. (författare)
Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, United States
Bowden, Donald W. (författare)
Biochemistry, Wake Forest School of Medicine, NC, Winston-Salem, United States
Deary, Ian J. (författare)
Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom
Dörr, Marcus (författare)
DZHK (German Centre for Cardiovascular Health), Partner Site Greifswald, Greifswald, Germany; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
Esko, Tõnu (författare)
Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia; Broad Institute of the Massachusetts Institute of Technology and Harvard University, MA, Boston, United States
Freedman, Barry I. (författare)
Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-, NC, Salem, United States
Froguel, Philippe (författare)
CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France; Department of Genomics of Common Disease, Imperial College London, London, United Kingdom
Gasparini, Paolo (författare)
Medical Genetics, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy; Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”, Trieste, Italy
Gieger, Christian (författare)
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
Jonas, Jost Bruno (författare)
Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany; Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Capital Medical University, Beijing, China
Kammerer, Candace M. (författare)
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States
Kato, Norihiro (författare)
Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
Lakka, Timo A. (författare)
Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
Leander, Karin (författare)
Karolinska Institutet
Lehtimäki, Terho (författare)
Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, University of Tampere, Tampere, Finland
Magnusson, Patrik K. E. (författare)
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden
Marques-Vidal, Pedro (författare)
Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Penninx, Brenda W. J. H. (författare)
Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, Netherlands
Samani, Nilesh J. (författare)
Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom
van der Harst, Pim (författare)
University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Ultrecht, Netherlands
Wagenknecht, Lynne E. (författare)
Public Health Sciences, Wake Forest School of Medicine, NC, Winston-Salem, United States
Wu, Tangchun (författare)
Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Zheng, Wei (författare)
Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, TN, Nashville, United States
Zhu, Xiaofeng (författare)
Department of Population and Quantitative Health Sciences, Case Western Reserve University, OH, Cleveland, United States
Bouchard, Claude (författare)
Human Genomics Laboratory, Pennington Biomedical Research Center, LA, Baton Rouge, United States
Cooper, Richard S. (författare)
Department of Public Health Sciences, Loyola University Chicago, IL, Maywood, United States
Correa, Adolfo (författare)
Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, MS, Jackson, United States
Evans, Michele K. (författare)
Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, MD, Baltimore, United States
Gudnason, Vilmundur (författare)
Icelandic Heart Association, Kopavogur, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Hayward, Caroline (författare)
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
Horta, Bernardo L. (författare)
Postgraduate Programme in Epidemiology, Federal University of Pelotas, RS, Pelotas, Brazil
Kelly, Tanika N. (författare)
Epidemiology, Tulane University School of Public Health and Tropical Medicine, LA, New Orleans, United States
Kritchevsky, Stephen B. (författare)
Sticht Center for Health Aging and Alzheimer’s Prevention, Department of Internal Medicine, Wake Forest School of Medicine, NC, Winston-Salem, United States
Levy, Daniel (författare)
NHLBI Framingham Heart Study, MA, Framingham, United States; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH, MD, Bethesda, United States
Palmas, Walter R. (författare)
Division of General Medicine, Department of Medicine, Columbia University Medical Center, NY, New York, United States
Pereira, A.C. (författare)
Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, SP, São Paulo, Brazil
Province, Michael M. (författare)
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, MO, St. Louis, United States
Psaty, Bruce M. (författare)
Cardiovascular Health Research Unit, Epidemiology, Medicine and Health Services, University of Washington, WA, Seattle, United States; Kaiser Permanente Washington Health Research Institute, WA, Seattle, United States
Ridker, Paul M. (författare)
Harvard Medical School, MA, Boston, United States; Brigham and Women’s Hospital, MA, Boston, United States
Rotimi, Charles N. (författare)
Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, MD, Bethesda, United States
Tai, E. Shyong (författare)
Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore; Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
van Dam, Rob M. (författare)
Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
van Duijn, Cornelia M. (författare)
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands; Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Wong, Tien Yin (författare)
Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Ecy Centre, Singapore, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore
Rice, Kenneth (författare)
Department of Biostatistics, University of Washington, WA, Seattle, United States
Gauderman, W. James (författare)
Biostatistics, Preventive Medicine, University of Southern California, CA, Los Angeles, United States
Morrison, Alanna C. (författare)
Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, TX, Houston, United States
North, Kari E. (författare)
Epidemiology, University of North Carolina Gilling School of Global Public Health, NC, Chapel Hill, United States
Kardia, Sharon L. R. (författare)
Department of Epidemiology, School of Public Health, University of Michigan, MI, Ann Arbor, United States
Caulfield, Mark J. (författare)
Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, London, United Kingdom
Elliott, Paul (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; MRC-PHE Centre for Environment and Health, Imperial College London, London, United Kingdom
Munroe, Patricia B. (författare)
Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, London, United Kingdom
Franks, Paul W. (författare)
Umeå University,Lund University,Lunds universitet,Umeå universitet,Avdelningen för hållbar hälsa,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Skåne, Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
Rao, Dabeeru C. (författare)
Division of Biostatistics, Washington University School of Medicine, MO, St. Louis, United States
Fornage, Myriam (författare)
Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, TX, Houston, United States
visa färre...
Cardiovascular Division, Department of Medicine, Washington University, MO, St Louis, United States; Division of Biostatistics, Washington University School of Medicine, MO, St. Louis, United States Division of Biostatistics, Washington University School of Medicine, MO, St. Louis, United States (creator_code:org_t)
et al 
2020-05-05
2021
Engelska.
Ingår i: Molecular Psychiatry. - : Springer Nature. - 1359-4184 .- 1476-5578. ; 26:6, s. 2111-2125
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, “Some College” (yes/no) and “Graduated College” (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects. Analyses were performed for systolic BP, diastolic BP, mean arterial pressure, and pulse pressure. We pursued genome-wide interrogation in Stage 1 studies (N = 117 438) and follow-up on promising variants in Stage 2 studies (N = 293 787) in five ancestry groups. Through combined meta-analyses of Stages 1 and 2, we identified 84 known and 18 novel BP loci at genome-wide significance level (P < 5 × 10-8). Two novel loci were identified based on the 1DF test of interaction with educational attainment, while the remaining 16 loci were identified through the 2DF joint test of genetic and interaction effects. Ten novel loci were identified in individuals of African ancestry. Several novel loci show strong biological plausibility since they involve physiologic systems implicated in BP regulation. They include genes involved in the central nervous system-adrenal signaling axis (ZDHHC17, CADPS, PIK3C2G), vascular structure and function (GNB3, CDON), and renal function (HAS2 and HAS2-AS1, SLIT3). Collectively, these findings suggest a role of educational attainment or SES in further dissection of the genetic architecture of BP.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Nyckelord

adult
ancestry group
article
blood pressure regulation
central nervous system
controlled study
diastolic blood pressure
dissection
female
follow up
human
kidney function
male
mean arterial pressure
mental capacity
meta analysis
protein function
pulse pressure
signal transduction
social status
structure activity relation
systolic blood pressure

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