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Molecular differenc...
Molecular differences in transition zone and peripheral zone prostate tumors
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- Sinnott, Jennifer A. (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston, USA; Department of Biostatistics, Harvard School of Public Health, Boston, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
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- Rider, Jennifer R. (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
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- Carlsson, Jessica, 1984- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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- Gerke, Travis (författare)
- Department of Epidemiology, College of Medicine and College of Public Health and Health Professions, University of Florida, Gainesville, USA
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- Tyekucheva, Svitlana (författare)
- Department of Biostatistics, Harvard School of Public Health, Boston, USA; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, USA
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- Penney, Kathryn L. (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
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- Sesso, Howard D. (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston, USA; Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
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- Loda, Massimo (författare)
- Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, USA
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- Fall, Katja, 1971- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Epidemiology, Harvard School of Public Health, Boston, USA
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- Stampfer, Meir J. (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
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- Mucci, Lorelei A. (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston, USA
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- Pawitan, Yudi (författare)
- Karolinska Institutet
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- Andersson, Sven-Olof, 1949- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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- Andrén, Ove, 1963- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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(creator_code:org_t)
- 2015-04-13
- 2015
- Engelska.
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Ingår i: Carcinogenesis. - Oxford, United Kingdom : Oxford University Press. - 0143-3334 .- 1460-2180. ; 36:6, s. 632-638
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Prostate tumors arise primarily in the peripheral zone (PZ) of the prostate, but 20-30% arise in the transition zone (TZ). Zone of origin may have prognostic value or reflect distinct molecular subtypes; however, it can be difficult to determine in practice. Using whole-genome gene expression, we built a signature of zone using normal tissue from five individuals and found that it successfully classified nine tumors of known zone. Hypothesizing that this signature captures tumor zone of origin, we assessed its relationship with clinical factors among 369 tumors of unknown zone from radical prostatectomies (RPs) and found that tumors that molecularly resembled TZ tumors showed lower mortality (P = 0.09) that was explained by lower Gleason scores (P = 0.009). We further applied the signature to an earlier study of 88 RP and 333 transurethral resection of the prostate (TURP) tumor samples, also of unknown zone, with gene expression on ~6000 genes. We had observed previously substantial expression differences between RP and TURP specimens, and hypothesized that this might be because RPs capture primarily PZ tumors, whereas TURPs capture more TZ tumors. Our signature distinguished these two groups, with an area under the receiver operating characteristic curve of 87% (P < 0.0001). Our findings that zonal differences in normal tissue persist in tumor tissue and that these differences are associated with Gleason score and sample type suggest that subtypes potentially resulting from different etiologic pathways might arise in these zones. Zone of origin may be important to consider in prostate tumor biomarker research.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Onkologi
- Oncology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Sinnott, Jennife ...
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Rider, Jennifer ...
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Carlsson, Jessic ...
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Gerke, Travis
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Tyekucheva, Svit ...
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Penney, Kathryn ...
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visa fler...
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Sesso, Howard D.
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Loda, Massimo
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Fall, Katja, 197 ...
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Stampfer, Meir J ...
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Mucci, Lorelei A ...
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Pawitan, Yudi
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Andersson, Sven- ...
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Andrén, Ove, 196 ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Carcinogenesis
- Av lärosätet
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Örebro universitet
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Karolinska Institutet