Nightmares share genetic risk factors with sleep and psychiatric traits

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Nightmares share genetic risk factors with sleep and psychiatric traits

Ollila, Hanna M. (författare): Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland ; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States ; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States ; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States

Sinnott-Armstrong, Nasa (författare): Department of Genetics, School of Medicine, Stanford University, CA, United States

Kantojärvi, Katri (författare): Population Health, Finnish Institute for Health and Welfare, Helsinki, Finland ; Department of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Finland

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Broberg, Martin (författare): Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland

Palviainen, Teemu (författare): Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland

Jones, Samuel (författare): Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland

Ripatti, Vili (författare): Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland

Pandit, Anita (författare): Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, United States

Rong, Robin (författare): Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, United States

Kristiansson, Kati (författare): Population Health, Finnish Institute for Health and Welfare, Helsinki, Finland

Sandman, Nils (författare): Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland

Valli, Katja, 1973- (författare): Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland,Kognitiv Neurovetenskap och Filosofi, Consciousness and Cognitive Neuroscience

Hublin, Christer (författare): Finnish Institute of Occupational Health, Helsinki, Finland

Ripatti, Samuli (författare): Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland ; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States ; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States

Widen, Elisabeth (författare): Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland

Kaprio, Jaakko (författare): Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland

Saxena, Richa (författare): Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States ; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States ; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States ; Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States

Paunio, Tiina (författare): Population Health, Finnish Institute for Health and Welfare, Helsinki, Finland ; Department of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Finland

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Springer Nature, 2024
2024
Engelska.
Ingår i: Translational Psychiatry. - : Springer Nature. - 2158-3188. ; 14:1

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://his.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Nightmares are vivid, extended, and emotionally negative or negative dreams that awaken the dreamer. While sporadic nightmares and bad dreams are common and generally harmless, frequent nightmares often reflect underlying pathologies of emotional regulation. Indeed, insomnia, depression, anxiety, or alcohol use have been associated with nightmares in epidemiological and clinical studies. However, the connection between nightmares and their comorbidities are poorly understood. Our goal was to examine the genetic risk factors for nightmares and estimate correlation or causality between nightmares and comorbidities. We performed a genome-wide association study (GWAS) in 45,255 individuals using a questionnaire-based assessment on the frequency of nightmares during the past month and genome-wide genotyping data. While the GWAS did not reveal individual risk variants, heritability was estimated at 5%. In addition, the genetic correlation analysis showed a robust correlation (rg > 0.4) of nightmares with anxiety (rg = 0.671, p = 7.507e−06), depressive (rg = 0.562, p = 1.282e−07) and posttraumatic stress disorders (rg = 0.4083, p = 0.0152), and personality trait neuroticism (rg = 0.667, p = 4.516e−07). Furthermore, Mendelian randomization suggested causality from insomnia to nightmares (beta = 0.027, p = 0.0002). Our findings suggest that nightmares share genetic background with psychiatric traits and that insomnia may increase an individual’s liability to experience frequent nightmares. Given the significant correlations with psychiatric and psychological traits, it is essential to grow awareness of how nightmares affect health and disease and systematically collect information about nightmares, especially from clinical samples and larger cohorts.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
SAMHÄLLSVETENSKAP -- Psykologi -- Psykologi (hsv//swe)
SOCIAL SCIENCES -- Psychology -- Psychology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Consciousness and Cognitive Neuroscience
Kognitiv neurovetenskap och filosofi

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