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Advanced parental age as risk factor for childhood acute lymphoblastic leukemia : results from studies of the Childhood Leukemia International Consortium

Petridou, Eleni Th. (författare)
Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden;Univ Athens, Med Sch, Dept Hyg Epidemiol & Med Stat, 75 Mikras Asias Str, Athens 11527, Greece
Georgakis, Marios K. (författare)
Univ Athens, Med Sch, Dept Hyg Epidemiol & Med Stat, 75 Mikras Asias Str, Athens 11527, Greece
Erdmann, Friederike (författare)
Danish Canc Soc Res Ctr, Childhood Canc Survivorship Res Grp, Unit Survivorship, Copenhagen, Denmark;Int Agcy Res Canc, Sect Environm & Radiat, Lyon, France
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Ma, Xiaomei (författare)
Yale Sch Med, Yale Comprehens Canc Ctr, Yale Sch Publ Hlth Canc Prevent & Control, Dept Chron Dis Epidemiol, New Haven, CT USA
Heck, Julia E. (författare)
Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90024 USA
Auvinen, Anssi (författare)
Univ Tampere, Fac Social Sci, Tampere, Finland
Mueller, Beth A. (författare)
Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA;Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, Seattle, WA USA
Spector, Logan G. (författare)
Univ Minnesota, Dept Pediat, Div Epidemiol & Clin Res, Minneapolis, MN 55455 USA
Roman, Eve (författare)
Univ York, Dept Hlth Sci, Epidemiol & Canc Stat Grp, York, N Yorkshire, England
Metayer, Catherine (författare)
Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA
Magnani, Corrado (författare)
Univ Piemonte Orientale, SCDU Epidemiol Tumori, Dipartimento Med Traslazi, Novara, Italy
Pombo-de-Oliveira, Maria S. (författare)
Inst Nacl Canc, Pediat Hematol Oncol Program, Rio De Janeiro, Brazil
Ezzat, Sameera (författare)
Menoufia Univ, Natl Liver Inst, NLI SSI Collaborat Res Ctr, Dept Epidemiol & Prevent Med, Cairo, Egypt
Scheurer, Michael E. (författare)
Baylor Coll Med, Texas Childrens Canc Ctr, Dept Pediat, Houston, TX 77030 USA
Maria Mora, Ana (författare)
Univ Nacl, Cent Amer Inst Studies Toxic Subst IRET, Heredia, Costa Rica
Dockerty, John D. (författare)
Univ Otago, Dunedin Sch Med, Dept Preventat & Social Med, Dunedin, New Zealand
Hansen, Johnni (författare)
Danish Canc Soc, Res Ctr, Copenhagen, Denmark
Kang, Alice Y. (författare)
Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA
Wang, Rong (författare)
Yale Sch Med, Yale Comprehens Canc Ctr, Yale Sch Publ Hlth Canc Prevent & Control, Dept Chron Dis Epidemiol, New Haven, CT USA
Doody, David R. (författare)
Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, Seattle, WA USA
Kane, Eleanor (författare)
Univ York, Dept Hlth Sci, Epidemiol & Canc Stat Grp, York, N Yorkshire, England
Rashed, Waffa M. (författare)
Childrens Canc Hosp Egypt, Res Dept, Cairo, Egypt;Armed Forces Coll Med, Biomed Res Dept, Cairo, Egypt
Dessypris, Nick (författare)
Univ Athens, Med Sch, Dept Hyg Epidemiol & Med Stat, 75 Mikras Asias Str, Athens 11527, Greece
Schuz, Joachim (författare)
Int Agcy Res Canc, Sect Environm & Radiat, Lyon, France
Infante-Rivard, Claire (författare)
McGill Univ, Fac Med, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada
Skalkidou, Alkistis, 1977- (författare)
Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning
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 (creator_code:org_t)
2018-05-14
2018
Engelska.
Ingår i: European Journal of Epidemiology. - : SPRINGER. - 0393-2990 .- 1573-7284. ; 33:10, s. 965-976
Relaterad länk:
https://europepmc.or...
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https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Advanced parental age has been associated with adverse health effects in the offspring including childhood (0-14 years) acute lymphoblastic leukemia (ALL), as reported in our meta-analysis of published studies. We aimed to further explore the association using primary data from 16 studies participating in the Childhood Leukemia International Consortium. Data were contributed by 11 case-control (CC) studies (7919 cases and 12,942 controls recruited via interviews) and five nested case-control (NCC) studies (8801 cases and 29,690 controls identified through record linkage of population-based health registries) with variable enrollment periods (1968-2015). Five-year paternal and maternal age increments were introduced in two meta-analyses by study design using adjusted odds ratios (OR) derived from each study. Increased paternal age was associated with greater ALL risk in the offspring (ORCC 1.05, 95% CI 1.00-1.11; ORNCC 1.04, 95% CI 1.01-1.07). A similar positive association with advanced maternal age was observed only in the NCC results (ORCC 0.99, 95% CI 0.91-1.07, heterogeneity I (2) = 58%, p = 0.002; ORNCC 1.05, 95% CI 1.01-1.08). The positive association between parental age and risk of ALL was most marked among children aged 1-5 years and remained unchanged following mutual adjustment for the collinear effect of the paternal and maternal age variables; analyses of the relatively small numbers of discordant paternal-maternal age pairs were not fully enlightening. Our results strengthen the evidence that advanced parental age is associated with increased childhood ALL risk; collinearity of maternal with paternal age complicates causal interpretation. Employing datasets with cytogenetic information may further elucidate involvement of each parental component and clarify underlying mechanisms.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Nyckelord

Maternal age
Paternal age
Acute lymphoblastic leukemia
Childhood
Risk factors
Case-control

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