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Establishment and c...
Establishment and characterization of a mouse strain (TLL) that spontaneously develops T-cell lymphomas/leukemia
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- Eriksson, Björn (författare)
- Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
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- Johansson, Ann-Sofie, 1967- (författare)
- Umeå universitet,Onkologi
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- Roos, Göran (författare)
- Umeå universitet,Institutionen för medicinsk biovetenskap
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Levan, Göran (författare)
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- Holmberg, Dan (författare)
- Umeå universitet,Institutionen för medicinsk biovetenskap
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(creator_code:org_t)
- 1999
- 1999
- Engelska.
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Ingår i: Experimental Hematology. - 0301-472X .- 1873-2399. ; 27:4, s. 682-688
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In this study, a mouse strain (TLL) that spontaneously develops T-cell lymphomas/leukemia with an early onset and high incidence was established and characterized. All tumors analyzed were found to express the alpha,beta T-cell receptor, and the majority of them had a mature, CD3+CD4+CD8- immunophenotype. In a few cases, tumors with a more immature CD3+CD4+CD8+ phenotype were isolated. Expanded phenotyping using a broad panel of lymphocyte differentiation markers confirmed the mature T-cell phenotype of the tumors. Histologic and cell cycle analysis of the tumors revealed an aggressive lymphoblastic malignancy with a very high proliferation rate and widespread engagement of bone marrow and lymphoid as well as nonlymphoid organs. Thus, the TLL mouse strain represents a unique model for the analysis of the oncogenesis and progression of mature T-cell tumors and for the development of therapeutic measures to combat such tumors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- T-cell lymphoma
- t-cell leukemia
- cd3 antigen
- cd4 antigen
- cd8 antigen
- Oncology
- Onkologi
- onkologi
- Oncology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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