Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.

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Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.

Cheng, Yu-Ching (author): University of Maryland

Stanne, Tara M, 1979 (author): University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology

Giese, Anne-Katrin (author): University of Rostock

Ho, Weang Kee (author): University of Nottingham

Traylor, Matthew (author): University of Cambridge

Amouyel, Philippe (author): Pasteur Institute of Lille

Holliday, Elizabeth G (author): University of Newcastle

Malik, Rainer (author): Ludwig-Maximilian University of Munich

Xu, Huichun (author): University of Maryland

Kittner, Steven J (author): University of Maryland

Cole, John W (author)

O'Connell, Jeffrey R (author)

Danesh, John (author)

Rasheed, Asif (author)

Zhao, Wei (author)

Engelter, Stefan (author)

Grond-Ginsbach, Caspar (author)

Kamatani, Yoichiro (author)

Lathrop, Mark (author)

Leys, Didier (author)

Thijs, Vincent (author)

Metso, Tiina M (author)

Tatlisumak, Turgut (author)

Pezzini, Alessandro (author)

Parati, Eugenio A (author)

Norrving, Bo (author): Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Stroke policy och kvalitetsregisterforskning,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Stroke policy and quality register research,Lund University Research Groups

Bevan, Steve (author)

Rothwell, Peter M (author)

Sudlow, Cathie (author)

Slowik, Agnieszka (author)

Lindgren, Arne (author): Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups

Walters, Matthew R (author)

Jannes, Jim (author)

Shen, Jess (author)

Crosslin, David (author)

Doheny, Kimberly (author)

Laurie, Cathy C (author)

Kanse, Sandip M (author)

Bis, Joshua C (author)

Fornage, Myriam (author)

Mosley, Thomas H (author)

Hopewell, Jemma C (author)

Strauch, Konstantin (author)

Müller-Nurasyid, Martina (author)

Gieger, Christian (author)

Waldenberger, Melanie (author)

Peters, Annette (author)

Meisinger, Christine (author)

Ikram, M Arfan (author)

Longstreth, W T (author)

Meschia, James F (author)

Seshadri, Sudha (author)

Sharma, Pankaj (author)

Worrall, Bradford (author)

Jern, Christina, 1962 (author): Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology

Levi, Christopher (author)

Dichgans, Martin (author)

Boncoraglio, Giorgio B (author)

Markus, Hugh S (author)

Debette, Stephanie (author)

Rolfs, Arndt (author)

Saleheen, Danish (author)

Mitchell, Braxton D (author)

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(creator_code:org_t)

2016
2016
English.
In: Stroke; a journal of cerebral circulation. - 1524-4628. ; 47:2, s. 307-16

Related links:: http://www.ncbi.nlm....; show more...; http://dx.doi.org/10...; https://gup.ub.gu.se...; https://doi.org/10.1...; https://lup.lub.lu.s...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

BACKGROUND Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show pleiotropy; that is, they are also associated with other diseases or traits. OBJECTIVES This study sought to systematically test if genetic variants identified for non-CAD diseases/traits also associate with CAD and to undertake a comprehensive analysis of the extent of pleiotropy of all CAD loci. METHODS In discovery analyses involving 42,335 CAD cases and 78,240 control subjects we tested the association of 29,383 common (minor allele frequency >5%) single nucleotide polymorphisms available on the exome array, which included a substantial proportion of known or suspected single nucleotide polymorphisms associated with common diseases or traits as of 2011. Suggestive association signals were replicated in an additional 30,533 cases and 42,530 control subjects. To evaluate pleiotropy, we tested CAD loci for association with cardiovascular risk factors (lipid traits, blood pressure phenotypes, body mass index, diabetes, and smoking behavior), as well as with other diseases/traits through interrogation of currently available genome-wide association study catalogs. RESULTS We identified 6 new loci associated with CAD at genome-wide significance: on 2q37 (KCNJ13-GIGYF2), 6p21 (C2), 11p15 (MRVI1-CTR9), 12q13 (LRP1), 12q24 (SCARB1), and 16q13 (CETP). Risk allele frequencies ranged from 0.15 to 0.86, and odds ratio per copy of the risk allele ranged from 1.04 to 1.09. Of 62 new and known CAD loci, 24 (38.7%) showed statistical association with a traditional cardiovascular risk factor, with some showing multiple associations, and 29 (47%) showed associations at p < 1 x 10(-4) with a range of other diseases/traits. CONCLUSIONS We identified 6 loci associated with CAD at genome-wide significance. Several CAD loci show substantial pleiotropy, which may help us understand the mechanisms by which these loci affect CAD risk.

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By the author/editor: Cheng, Yu-Ching; Stanne, Tara M, ...; Giese, Anne-Katr ...; Ho, Weang Kee; Traylor, Matthew; Amouyel, Philipp ...; show more...; Holliday, Elizab ...; Malik, Rainer; Xu, Huichun; Kittner, Steven ...; Cole, John W; O'Connell, Jeffr ...; Danesh, John; Rasheed, Asif; Zhao, Wei; Engelter, Stefan; Grond-Ginsbach, ...; Kamatani, Yoichi ...; Lathrop, Mark; Leys, Didier; Thijs, Vincent; Metso, Tiina M; Tatlisumak, Turg ...; Pezzini, Alessan ...; Parati, Eugenio ...; Norrving, Bo; Bevan, Steve; Rothwell, Peter ...; Sudlow, Cathie; Slowik, Agnieszk ...; Lindgren, Arne; Walters, Matthew ...; Jannes, Jim; Shen, Jess; Crosslin, David; Doheny, Kimberly; Laurie, Cathy C; Kanse, Sandip M; Bis, Joshua C; Fornage, Myriam; Mosley, Thomas H; Hopewell, Jemma ...; Strauch, Konstan ...; Müller-Nurasyid, ...; Gieger, Christia ...; Waldenberger, Me ...; Peters, Annette; Meisinger, Chris ...; Ikram, M Arfan; Longstreth, W T; Meschia, James F; Seshadri, Sudha; Sharma, Pankaj; Worrall, Bradfor ...; Jern, Christina, ...; Levi, Christophe ...; Dichgans, Martin; Boncoraglio, Gio ...; Markus, Hugh S; Debette, Stephan ...; Rolfs, Arndt; Saleheen, Danish; Mitchell, Braxto ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

Articles in the publication: Stroke; a journa ...

By the university: University of Gothenburg; Lund University

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Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.

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