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Simple cardiovascul...
Simple cardiovascular risk stratification by replacing total serum cholesterol with anthropometric measures : The MORGAM prospective cohort project
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- Rosberg, Victoria (författare)
- Department of Cardiology, North Zealand Hospital, Hillerød, Denmark
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- Vishram-Nielsen, Julie KK (författare)
- Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark, Copenhagen, Frederiksberg, Denmark,Finnish National Institute for Health and Welfare
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- Kristensen, Anna M. Dyrvig (författare)
- Department of Cardiology, North Zealand Hospital, Hillerød, Denmark,University Hospital Of Strasbourg
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- Pareek, Manan (författare)
- Department of Cardiology, North Zealand Hospital, Hillerød, Denmark; Department of Internal Medicine, Yale New Haven Hospital, Yale University School of Medicine, CT, New Haven, United States
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- Sehested, Thomas S.G. (författare)
- Umeå University,UiT The Arctic University of Norway, Tromsø
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- Nilsson, Peter M. (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Linneberg, Allan (författare)
- Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark, Copenhagen, Frederiksberg, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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- Palmieri, Luigi (författare)
- Department of Cardiovascular, Endocrine-metabolic Diseases and Aging, Istituto Superiore di Sanità (ISS), Rome, Italy,Italian National Institute of Health (ISS)
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- Giampaoli, Simona (författare)
- Department of Cardiovascular, Endocrine-metabolic Diseases and Aging, Istituto Superiore di Sanità (ISS), Rome, Italy
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- Donfrancesco, Chiara (författare)
- Department of Cardiovascular, Endocrine-metabolic Diseases and Aging, Istituto Superiore di Sanità (ISS), Rome, Italy,Italian National Institute of Health (ISS)
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- Kee, Frank (författare)
- Centre for Public Health, The Queeńs University of Belfast, Ireland
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- Mancia, Giuseppe (författare)
- University of Milano-Bicocca and Policlinico di Monza, Monza, Italy
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- Cesana, Giancarlo (författare)
- Research Centre on Public Health, University of Milano Bicocca, Villa Serena, Monza, Italy
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- Veronesi, Giovanni (författare)
- Research Centre in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Italy
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- Grassi, Guido (författare)
- Clinica Medica, University Milano Bicocca, Monza, Italy
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- Kuulasmaa, Kari (författare)
- Finnish Institute for Health and Welfare (THL), Helsinki, Finland
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- Salomaa, Veikko (författare)
- Finnish Institute for Health and Welfare (THL), Helsinki, Finland,Finnish National Institute for Health and Welfare
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- Palosaari, Tarja (författare)
- Finnish Institute for Health and Welfare (THL), Helsinki, Finland,Finnish National Institute for Health and Welfare
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- Sans, Susana (författare)
- Catalan Department of Health, Barcelona, Spain
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- Ferrieres, Jean (författare)
- Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse Cedex 9, France
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- Dallongeville, Jean (författare)
- Institut Pasteur de Lille, Lille Cedex, France
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- Söderberg, Stefan (författare)
- Umeå universitet,Kardiologi
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- Moitry, Marie (författare)
- Department of Epidemiology and Public Health, University of Strasbourg and University Hospital of Strasbourg, Strasbourg, France
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- Drygas, Wojciech (författare)
- Department of Epidemiology, CVD Prevention and Health Promotion, National Institute of Cardiology, Warsaw, Poland,Cardinal Wyszynski National Institute of Cardiology
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- Tamosiunas, Abdonas (författare)
- Lithuanian University of Health Sciences, Institute of Cardiology, Kaunas, Lithuania
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- Peters, Annette (författare)
- Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
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- Brenner, Hermann (författare)
- German Cancer Research Center (DKFZ), Heidelberg, Germany, Network Aging Research (NAR), Heidelberg University, Heidelberg, Germany
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- Schöttker, Ben (författare)
- Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany
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- Grimsgaard, Sameline (författare)
- Department of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway
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- Biering-Sørensen, Tor (författare)
- Department of Cardiology, Herlev and Gentofte Hospital, Copenhagen, Denmark; Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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- Olsen, Michael H (författare)
- Department of Internal Medicine, Steno Diabetes Center Zealand, Holbaek Hospital, Holbaek, Denmark; Department of Regional Health Research, University of Southern Denmark, Denmark
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Preventive Medicine Reports. - : Elsevier. - 2211-3355. ; 26
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- To assess whether anthropometric measures (body mass index [BMI], waist-hip ratio [WHR], and estimated fat mass [EFM]) are independently associated with major adverse cardiovascular events (MACE), and to assess their added prognostic value compared with serum total-cholesterol. The study population comprised 109,509 individuals (53% men) from the MORGAM-Project, aged 19–97 years, without established cardiovascular disease, and not on antihypertensive treatment. While BMI was reported in all, WHR and EFM were reported in ∼52,000 participants. Prognostic importance of anthropometric measurements and total-cholesterol was evaluated using adjusted Cox proportional-hazards regression, logistic regression, area under the receiver-operating-characteristic curve (AUCROC), and net reclassification improvement (NRI). The primary endpoint was MACE, a composite of stroke, myocardial infarction, or death from coronary heart disease. Age interacted significantly with anthropometric measures and total-cholesterol on MACE (P ≤ 0.003), and therefore age-stratified analyses (<50 versus ≥ 50 years) were performed. BMI, WHR, EFM, and total-cholesterol were independently associated with MACE (P ≤ 0.003) and resulted in significantly positive NRI when added to age, sex, smoking status, and systolic blood pressure. Only total-cholesterol increased discrimination ability (AUCROC difference; P < 0.001). In subjects < 50 years, the prediction model with total-cholesterol was superior to the model including BMI, but not superior to models containing WHR or EFM, while in those ≥ 50 years, the model with total-cholesterol was superior to all models containing anthropometric variables, whether assessed individually or combined. We found a potential role for replacing total-cholesterol with anthropometric measures for MACE-prediction among individuals < 50 years when laboratory measurements are unavailable, but not among those ≥ 50 years.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Adipose tissue
- Assessment
- risk
- Body mass index
- Cardiovascular diseases
- Cholesterol
- Waist-hip ratio
- Adipose tissue
- Assessment, risk
- Body mass index
- Cardiovascular diseases
- Cholesterol
- Waist-hip ratio
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Rosberg, Victori ...
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Vishram-Nielsen, ...
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Kristensen, Anna ...
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Pareek, Manan
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Sehested, Thomas ...
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Nilsson, Peter M ...
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visa fler...
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Linneberg, Allan
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Palmieri, Luigi
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Giampaoli, Simon ...
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Donfrancesco, Ch ...
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Kee, Frank
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Mancia, Giuseppe
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Cesana, Giancarl ...
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Veronesi, Giovan ...
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Grassi, Guido
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Kuulasmaa, Kari
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Salomaa, Veikko
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Palosaari, Tarja
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Sans, Susana
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Ferrieres, Jean
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Dallongeville, J ...
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Söderberg, Stefa ...
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Moitry, Marie
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Drygas, Wojciech
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Tamosiunas, Abdo ...
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Peters, Annette
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Brenner, Hermann
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Schöttker, Ben
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Grimsgaard, Same ...
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Biering-Sørensen ...
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Olsen, Michael H
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Preventive Medic ...
- Av lärosätet
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Umeå universitet
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Lunds universitet