Impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in patients with severe asthma

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Impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in patients with severe asthma

Perez-de-Llano, Luis (författare): University Hospital Lucus Augusti

Scelo, Ghislaine (författare): Observational and Pragmatic Research Institute Pte Ltd

Canonica, G. Walter (författare): Humanitas University,Humanitas Research Hospital

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Chen, Wenjia (författare): National University of Singapore

Henley, William (författare): University of Exeter,Observational and Pragmatic Research Institute Pte Ltd

Larenas-Linnemann, Désirée (författare)

Peters, Matthew J. (författare): Concord Repatriation General Hospital,Macquarie University, Sydney

Pfeffer, Paul E. (författare): Barts Health NHS Trust,Queen Mary University

Tran, Trung N. (författare): AstraZeneca, UK

Ulrik, Charlotte Suppli (författare): Hvidovre Hospital

Popov, Todor A. (författare): University Hospital St. Ivan Rilski

Sadatsafavi, Mohsen (författare): University of British Columbia

Hew, Mark (författare): Monash University

Máspero, Jorge (författare): University of Buenos Aires

Gibson, Peter G. (författare): Hunter Medical Research Institute, Australia,University of Newcastle

Christoff, George C. (författare): Medical University of Sofia

Fitzgerald, J. Mark (författare): University of British Columbia

Torres-Duque, Carlos A. (författare): University Of La Sabana

Porsbjerg, Celeste M. (författare): Bispebjerg Hospital

Papadopoulos, Nikolaos G (författare): National and Kapodistrian University of Athens,University of Manchester

Papaioannou, Andriana I. (författare): National and Kapodistrian University of Athens

Heffler, Enrico (författare): Humanitas University,Humanitas Research Hospital

Iwanaga, Takashi (författare)

Al-Ahmad, Mona (författare): Kuwait University

Kuna, Piotr (författare): Medical University of Lodz

Fonseca, João A. (författare): University of Porto

Al-Lehebi, Riyad (författare): Alfaisal University

Rhee, Chin Kook (författare)

Koh, Mariko Siyue (författare): Singapore General Hospital

Cosio, Borja G. (författare): Hospital Universitario Son Espases

Perng (Steve), Diahn Warng (författare): Taipei Veterans General Hospital,National Yang-Ming University Taiwan

Mahboub, Bassam (författare)

Menzies-Gow, Andrew N. (författare): Royal Brompton and Harefield NHS Foundation Trust,AstraZeneca, UK

Jackson, David J. (författare): Guy's Hospital

Busby, John (författare)

Heaney, Liam G. (författare): Queen's University Belfast

Patel, Pujan H. (författare): Royal Brompton Hospital

Wang, Eileen (författare): University of Colorado School of Medicine

Wechsler, Michael E. (författare): National Jewish Health

Altraja, Alan (författare): University of Tartu

Lehtimäki, Lauri (författare): Tampere University Hospital,University of Tampere

Bourdin, Arnaud (författare)

Bjermer, Leif (författare): Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk lungmedicin,Forskargrupper vid Lunds universitet,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Respiratory Medicine,Lund University Research Groups,Skåne University Hospital

Bulathsinhala, Lakmini (författare): Observational and Pragmatic Research Institute Pte Ltd

Carter, Victoria (författare): Observational and Pragmatic Research Institute Pte Ltd

Murray, Ruth (författare)

Beastall, Aaron (författare): Observational and Pragmatic Research Institute Pte Ltd

Denton, Eve (författare): Monash University

Price, David B. (författare): Observational and Pragmatic Research Institute Pte Ltd,University of Aberdeen

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Engelska.
Ingår i: Annals of Allergy, Asthma and Immunology. - 1081-1206.

Relaterad länk:: http://dx.doi.org/10... (free); visa fler...; https://lup.lub.lu.s...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Background: There is little agreement on clinically useful criteria for identifying real-world responders to biologic treatments for asthma. Objective: To investigate the impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in adults with severe asthma. Methods: This was a longitudinal, cohort study across 22 countries participating in the International Severe Asthma Registry (https://isaregistries.org/) between May 2017 and January 2023. Change in 4 asthma domains (exacerbation rate, asthma control, long-term oral corticosteroid [LTOCS] dose, and lung function) was assessed from biologic initiation to 1 year post-treatment (minimum 24 weeks). Pre- to post-biologic changes for responders and nonresponders were described along a categorical gradient for each domain derived from pre-biologic distributions (exacerbation rate: 0 to 6+/y; asthma control: well controlled to uncontrolled; LTOCS: 0 to >30 mg/d; percent-predicted forced expiratory volume in 1 second [ppFEV1]: <50% to ≥80%). Results: Percentage of biologic responders (ie, those with a category improvement pre- to post-biologic) varied by domain and increased with greater pre-biologic impairment, increasing from 70.2% to 90.0% for exacerbation rate, 46.3% to 52.3% for asthma control, 31.1% to 58.5% for LTOCS daily dose, and 35.8% to 50.6% for ppFEV1. The proportion of patients having improvement post-biologic tended to be greater for anti–IL-5/5R compared with for anti-IgE for exacerbation, asthma control, and ppFEV1 domains, irrespective of pre-biologic impairment. Conclusion: Our results provide realistic outcome-specific post-biologic expectations for both physicians and patients, will be foundational to inform future work on a multidimensional approach to define and assess biologic responders and response, and may enhance appropriate patient selection for biologic therapies. Trial Registration: The ISAR database has ethical approval from the Anonymous Data Ethics Protocols and Transparency (ADEPT) committee (ADEPT0218) and is registered with the European Union Electronic Register of Post-Authorization studies (ENCEPP/DSPP/23720). The study was designed, implemented, and reported in compliance with the European Network Centres for Pharmacoepidemiology and Pharmacovigilance (ENCEPP) Code of Conduct (EUPAS38288) and with all applicable local and international laws and regulation, and registered with ENCEPP (https://www.encepp.eu/encepp/viewResource.htm?id=38289). Governance was provided by ADEPT (registration number: ADEPT1220).

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Annals of Allergy, Asthma and Immunology (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Perez-de-Llano, ...; Scelo, Ghislaine; Canonica, G. Wal ...; Chen, Wenjia; Henley, William; Larenas-Linneman ...; visa fler...; Peters, Matthew ...; Pfeffer, Paul E.; Tran, Trung N.; Ulrik, Charlotte ...; Popov, Todor A.; Sadatsafavi, Moh ...; Hew, Mark; Máspero, Jorge; Gibson, Peter G.; Christoff, Georg ...; Fitzgerald, J. M ...; Torres-Duque, Ca ...; Porsbjerg, Celes ...; Papadopoulos, Ni ...; Papaioannou, And ...; Heffler, Enrico; Iwanaga, Takashi; Al-Ahmad, Mona; Kuna, Piotr; Fonseca, João A.; Al-Lehebi, Riyad; Rhee, Chin Kook; Koh, Mariko Siyu ...; Cosio, Borja G.; Perng (Steve), D ...; Mahboub, Bassam; Menzies-Gow, And ...; Jackson, David J ...; Busby, John; Heaney, Liam G.; Patel, Pujan H.; Wang, Eileen; Wechsler, Michae ...; Altraja, Alan; Lehtimäki, Lauri; Bourdin, Arnaud; Bjermer, Leif; Bulathsinhala, L ...; Carter, Victoria; Murray, Ruth; Beastall, Aaron; Denton, Eve; Price, David B.; visa färre...

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Av lärosätet: Lunds universitet

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Impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in patients with severe asthma

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