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Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

de Vries, Paul S. (author)
University of Texas
Brown, Michael R. (author)
Bentley, Amy R. (author)
show more...
Sung, Yun J. (author)
Winkler, Thomas W. (author)
Ntalla, Ioanna (author)
Schwander, Karen (author)
Kraja, Aldi T. (author)
Guo, Xiuqing (author)
Franceschini, Nora (author)
Cheng, Ching-Yu (author)
Sim, Xueling (author)
Vojinovic, Dina (author)
Huffman, Jennifer E. (author)
Musani, Solomon K. (author)
Li, Changwei (author)
Feitosa, Mary F. (author)
Richard, Melissa A. (author)
Noordam, Raymond (author)
Aschard, Hugues (author)
Bartz, Traci M. (author)
Bielak, Lawrence F. (author)
Deng, Xuan (author)
Dorajoo, Rajkumar (author)
Lohman, Kurt K. (author)
Manning, Alisa K. (author)
Rankinen, Tuomo (author)
Smith, Albert V. (author)
Tajuddin, Salman M. (author)
Evangelou, Evangelos (author)
Karolinska Institutet
Graff, Mariaelisa (author)
Alver, Maris (author)
Boissel, Mathilde (author)
Chai, Jin Fang (author)
Chen, Xu (author)
Karolinska Institutet
Divers, Jasmin (author)
Gandin, Ilaria (author)
Gao, Chuan (author)
Goel, Anuj (author)
Hagemeijer, Yanick (author)
Harris, Sarah E. (author)
Hartwig, Fernando P. (author)
He, Meian (author)
Horimoto, Andrea R. V. R. (author)
Hsu, Fang-Chi (author)
Jackson, Anne U. (author)
Kasturiratne, Anuradhani (author)
Komulainen, Pirjo (author)
Kuehnel, Brigitte (author)
Laguzzi, Federica (author)
Karolinska Institutet
Lee, Joseph H. (author)
Luan, Jian'an (author)
Lyytikainen, Leo-Pekka (author)
Matoba, Nana (author)
Nolte, Ilja M. (author)
Pietzner, Maik (author)
Riaz, Muhammad (author)
Said, M. Abdullah (author)
Scott, Robert A. (author)
Sofer, Tamar (author)
Stancakova, Alena (author)
Takeuchi, Fumihiko (author)
Tayo, Bamidele O. (author)
van der Most, Peter J. (author)
V. Varga, Tibor (author)
Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital
Wang, Yajuan (author)
Ware, Erin B. (author)
Wen, Wanqing (author)
Yanek, Lisa R. (author)
Zhang, Weihua (author)
Zhao, Jing Hua (author)
Afaq, Saima (author)
Amin, Najaf (author)
Amini, Marzyeh (author)
Arking, Dan E. (author)
Aung, Tin (author)
Ballantyne, Christie (author)
Boerwinkle, Eric (author)
Broeckel, Ulrich (author)
Campbell, Archie (author)
Canouil, Mickael (author)
Charumathi, Sabanayagam (author)
Chen, Yii-Der Ida (author)
Connell, John M. (author)
de Faire, Ulf (author)
Karolinska Institutet
de las Fuentes, Lisa (author)
de Mutsert, Renee (author)
de Silva, H. Janaka (author)
Ding, Jingzhong (author)
Dominiczak, Anna F. (author)
Duan, Qing (author)
Eaton, Charles B. (author)
Eppinga, Ruben N. (author)
Faul, Jessica D. (author)
Fisher, Virginia (author)
Forrester, Terrence (author)
Franco, Oscar H. (author)
Friedlander, Yechiel (author)
Ghanbari, Mohsen (author)
Giulianini, Franco (author)
Grabe, Hans J. (author)
Grove, Megan L. (author)
Gu, C. Charles (author)
Harris, Tamara B. (author)
Heikkinen, Sami (author)
Heng, Chew-Kiat (author)
Hirata, Makoto (author)
Hixson, James E. (author)
Howard, Barbara V. (author)
Ikram, M. Arfan (author)
Jacobs, David R., Jr. (author)
Johnson, Craig (author)
Jonas, Jost Bruno (author)
Kammerer, Candace M. (author)
Katsuya, Tomohiro (author)
Khor, Chiea Chuen (author)
Kilpelainen, Tuomas O. (author)
Koh, Woon-Puay (author)
Koistinen, Heikki A. (author)
Kolcic, Ivana (author)
Kooperberg, Charles (author)
Krieger, Jose E. (author)
Kritchevsky, Steve B. (author)
Kubo, Michiaki (author)
Kuusisto, Johanna (author)
Lakka, Timo A. (author)
Langefeld, Carl D. (author)
Langenberg, Claudia (author)
Launer, Lenore J. (author)
Lehne, Benjamin (author)
Lemaitre, Rozenn N. (author)
Li, Yize (author)
Liang, Jingjing (author)
Liu, Jianjun (author)
Liu, Kiang (author)
Loh, Marie (author)
Louie, Tin (author)
Magi, Reedik (author)
Manichaikul, Ani W. (author)
McKenzie, Colin A. (author)
Meitinger, Thomas (author)
Metspalu, Andres (author)
Milaneschi, Yuri (author)
Milani, Lili (author)
Mohlke, Karen L. (author)
Karolinska Institutet
Mosley, Thomas H., Jr. (author)
Mukamal, Kenneth J. (author)
Nalls, Mike A. (author)
Nauck, Matthias (author)
Nelson, Christopher P. (author)
Sotoodehnia, Nona (author)
O'Connell, Jeff R. (author)
Palmer, Nicholette D. (author)
Pazoki, Raha (author)
Pedersen, Nancy L. (author)
Karolinska Institutet
Peters, Annette (author)
Peyser, Patricia A. (author)
Polasek, Ozren (author)
Poulter, Neil (author)
Raffel, Leslie J. (author)
Raitakari, Olli T. (author)
Reiner, Alex P. (author)
Rice, Treva K. (author)
Rich, Stephen S. (author)
Robino, Antonietta (author)
Robinson, Jennifer G. (author)
Rose, Lynda M. (author)
Rudan, Igor (author)
Schmidt, Carsten O. (author)
Schreiner, Pamela J. (author)
Scott, William R. (author)
Sever, Peter (author)
Shi, Yuan (author)
Sidney, Stephen (author)
Sims, Mario (author)
Smith, Blair H. (author)
Smith, Jennifer A. (author)
Snieder, Harold (author)
Starr, John M. (author)
Strauch, Konstantin (author)
Tan, Nicholas (author)
Taylor, Kent D. (author)
Teo, Yik Ying (author)
Tham, Yih Chung (author)
Uitterlinden, Andre G. (author)
van Heemst, Diana (author)
Vuckovic, Dragana (author)
Waldenberger, Melanie (author)
Wang, Lihua (author)
Wang, Yujie (author)
Wang, Zhe (author)
Wei, Wen Bin (author)
Williams, Christine (author)
Wilson, Gregory, Sr. (author)
Wojczynski, Mary K. (author)
Yao, Jie (author)
Yu, Bing (author)
Yu, Caizheng (author)
Yuan, Jian-Min (author)
Zhao, Wei (author)
Zonderman, Alan B. (author)
Becker, Diane M. (author)
Boehnke, Michael (author)
Bowden, Donald W. (author)
Chambers, John C. (author)
Deary, Ian J. (author)
Esko, Tonu (author)
Farrall, Martin (author)
Franks, Paul W. (author)
Umeå University,Lund University,Lunds universitet,Umeå universitet,Avdelningen för medicin,Department of Nutrition, T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Medical Sciences Division, University of Oxford, Oxford, United Kingdom,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
Freedman, Barry I. (author)
Froguel, Philippe (author)
Gasparini, Paolo (author)
Gieger, Christian (author)
Horta, Bernardo L. (author)
Kamatani, Yoichiro (author)
Kato, Norihiro (author)
Kooner, Jaspal S. (author)
Laakso, Markku (author)
Leander, Karin (author)
Lehtimaki, Terho (author)
Magnusson, Patrik K. E. (author)
Penninx, Brenda (author)
Pereira, Alexandre C. (author)
Rauramaa, Rainer (author)
Samani, Nilesh J. (author)
Scott, James (author)
Shu, Xiao-Ou (author)
van der Harst, Pim (author)
Wagenknecht, Lynne E. (author)
Wang, Ya Xing (author)
Wareham, Nicholas J. (author)
Watkins, Hugh (author)
Weir, David R. (author)
Wickremasinghe, Ananda R. (author)
Zheng, Wei (author)
Elliott, Paul (author)
North, Kari E. (author)
Bouchard, Claude (author)
Evans, Michele K. (author)
Gudnason, Vilmundur (author)
Liu, Ching-Ti (author)
Liu, Yongmei (author)
Psaty, Bruce M. (author)
Ridker, Paul M. (author)
van Dam, Rob M. (author)
Kardia, Sharon L. R. (author)
Zhu, Xiaofeng (author)
Rotimi, Charles N. (author)
Mook-Kanamori, Dennis O. (author)
Fornage, Myriam (author)
Kelly, Tanika N. (author)
Fox, Ervin R. (author)
Hayward, Caroline (author)
van Duijn, Cornelia M. (author)
Tai, E. Shyong (author)
Wong, Tien Yin (author)
Liu, Jingmin (author)
Rotter, Jerome I. (author)
Gauderman, W. James (author)
Province, Michael A. (author)
Munroe, Patricia B. (author)
Rice, Kenneth (author)
Chasman, Daniel I. (author)
Cupples, L. Adrienne (author)
Rao, Dabeeru C. (author)
Morrison, Alanna C. (author)
University of Texas
show less...
 (creator_code:org_t)
et al 
2019-01-29
2019
English.
In: American Journal of Epidemiology. - : Oxford University Press. - 0002-9262 .- 1476-6256. ; 188:6, s. 1033-1054
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in stage 1 (genome-wide discovery) and 66 studies in stage 2 (focused follow-up), for a total of 394,584 individuals from 5 ancestry groups. Analyses covered the period July 2014-November 2017. Genetic main effects and interaction effects were jointly assessed by means of a 2-degrees-of-freedom (df) test, and a 1-df test was used to assess the interaction effects alone. Variants at 495 loci were at least suggestively associated (P < 1 x 10(-6)) with lipid levels in stage 1 and were evaluated in stage 2, followed by combined analyses of stage 1 and stage 2. In the combined analysis of stages 1 and 2, a total of 147 independent loci were associated with lipid levels at P < 5 x 10(-8) using 2-df tests, of which 18 were novel. No genome-wide-significant associations were found testing the interaction effect alone. The novel loci included several genes (proprotein convertase subtilisin/kexin type 5 (PCSK5), vascular endothelial growth factor B (VEGFB), and apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1) complementation factor (A1CF)) that have a putative role in lipid metabolism on the basis of existing evidence from cellular and experimental models.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Keyword

alcohol consumption
cholesterol
gene-environment interactions
gene-lifestyle interactions
genome-wide association studies
lipids
triglycerides
alcohol consumption
cholesterol
gene-environment interactions
gene-lifestyle interactions
genome-wide association studies
lipids
triglycerides

Publication and Content Type

ref (subject category)
art (subject category)

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de Vries, Paul S ...
Brown, Michael R ...
Bentley, Amy R.
Sung, Yun J.
Winkler, Thomas ...
Ntalla, Ioanna
show more...
Schwander, Karen
Kraja, Aldi T.
Guo, Xiuqing
Franceschini, No ...
Cheng, Ching-Yu
Sim, Xueling
Vojinovic, Dina
Huffman, Jennife ...
Musani, Solomon ...
Li, Changwei
Feitosa, Mary F.
Richard, Melissa ...
Noordam, Raymond
Aschard, Hugues
Bartz, Traci M.
Bielak, Lawrence ...
Deng, Xuan
Dorajoo, Rajkuma ...
Lohman, Kurt K.
Manning, Alisa K ...
Rankinen, Tuomo
Smith, Albert V.
Tajuddin, Salman ...
Evangelou, Evang ...
Graff, Mariaelis ...
Alver, Maris
Boissel, Mathild ...
Chai, Jin Fang
Chen, Xu
Divers, Jasmin
Gandin, Ilaria
Gao, Chuan
Goel, Anuj
Hagemeijer, Yani ...
Harris, Sarah E.
Hartwig, Fernand ...
He, Meian
Horimoto, Andrea ...
Hsu, Fang-Chi
Jackson, Anne U.
Kasturiratne, An ...
Komulainen, Pirj ...
Kuehnel, Brigitt ...
Laguzzi, Federic ...
Lee, Joseph H.
Luan, Jian'an
Lyytikainen, Leo ...
Matoba, Nana
Nolte, Ilja M.
Pietzner, Maik
Riaz, Muhammad
Said, M. Abdulla ...
Scott, Robert A.
Sofer, Tamar
Stancakova, Alen ...
Takeuchi, Fumihi ...
Tayo, Bamidele O ...
van der Most, Pe ...
V. Varga, Tibor
Wang, Yajuan
Ware, Erin B.
Wen, Wanqing
Yanek, Lisa R.
Zhang, Weihua
Zhao, Jing Hua
Afaq, Saima
Amin, Najaf
Amini, Marzyeh
Arking, Dan E.
Aung, Tin
Ballantyne, Chri ...
Boerwinkle, Eric
Broeckel, Ulrich
Campbell, Archie
Canouil, Mickael
Charumathi, Saba ...
Chen, Yii-Der Id ...
Connell, John M.
de Faire, Ulf
de las Fuentes, ...
de Mutsert, Rene ...
de Silva, H. Jan ...
Ding, Jingzhong
Dominiczak, Anna ...
Duan, Qing
Eaton, Charles B ...
Eppinga, Ruben N ...
Faul, Jessica D.
Fisher, Virginia
Forrester, Terre ...
Franco, Oscar H.
Friedlander, Yec ...
Ghanbari, Mohsen
Giulianini, Fran ...
Grabe, Hans J.
Grove, Megan L.
Gu, C. Charles
Harris, Tamara B ...
Heikkinen, Sami
Heng, Chew-Kiat
Hirata, Makoto
Hixson, James E.
Howard, Barbara ...
Ikram, M. Arfan
Jacobs, David R. ...
Johnson, Craig
Jonas, Jost Brun ...
Kammerer, Candac ...
Katsuya, Tomohir ...
Khor, Chiea Chue ...
Kilpelainen, Tuo ...
Koh, Woon-Puay
Koistinen, Heikk ...
Kolcic, Ivana
Kooperberg, Char ...
Krieger, Jose E.
Kritchevsky, Ste ...
Kubo, Michiaki
Kuusisto, Johann ...
Lakka, Timo A.
Langefeld, Carl ...
Langenberg, Clau ...
Launer, Lenore J ...
Lehne, Benjamin
Lemaitre, Rozenn ...
Li, Yize
Liang, Jingjing
Liu, Jianjun
Liu, Kiang
Loh, Marie
Louie, Tin
Magi, Reedik
Manichaikul, Ani ...
McKenzie, Colin ...
Meitinger, Thoma ...
Metspalu, Andres
Milaneschi, Yuri
Milani, Lili
Mohlke, Karen L.
Mosley, Thomas H ...
Mukamal, Kenneth ...
Nalls, Mike A.
Nauck, Matthias
Nelson, Christop ...
Sotoodehnia, Non ...
O'Connell, Jeff ...
Palmer, Nicholet ...
Pazoki, Raha
Pedersen, Nancy ...
Peters, Annette
Peyser, Patricia ...
Polasek, Ozren
Poulter, Neil
Raffel, Leslie J ...
Raitakari, Olli ...
Reiner, Alex P.
Rice, Treva K.
Rich, Stephen S.
Robino, Antoniet ...
Robinson, Jennif ...
Rose, Lynda M.
Rudan, Igor
Schmidt, Carsten ...
Schreiner, Pamel ...
Scott, William R ...
Sever, Peter
Shi, Yuan
Sidney, Stephen
Sims, Mario
Smith, Blair H.
Smith, Jennifer ...
Snieder, Harold
Starr, John M.
Strauch, Konstan ...
Tan, Nicholas
Taylor, Kent D.
Teo, Yik Ying
Tham, Yih Chung
Uitterlinden, An ...
van Heemst, Dian ...
Vuckovic, Dragan ...
Waldenberger, Me ...
Wang, Lihua
Wang, Yujie
Wang, Zhe
Wei, Wen Bin
Williams, Christ ...
Wilson, Gregory, ...
Wojczynski, Mary ...
Yao, Jie
Yu, Bing
Yu, Caizheng
Yuan, Jian-Min
Zhao, Wei
Zonderman, Alan ...
Becker, Diane M.
Boehnke, Michael
Bowden, Donald W ...
Chambers, John C ...
Deary, Ian J.
Esko, Tonu
Farrall, Martin
Franks, Paul W.
Freedman, Barry ...
Froguel, Philipp ...
Gasparini, Paolo
Gieger, Christia ...
Horta, Bernardo ...
Kamatani, Yoichi ...
Kato, Norihiro
Kooner, Jaspal S ...
Laakso, Markku
Leander, Karin
Lehtimaki, Terho
Magnusson, Patri ...
Penninx, Brenda
Pereira, Alexand ...
Rauramaa, Rainer
Samani, Nilesh J ...
Scott, James
Shu, Xiao-Ou
van der Harst, P ...
Wagenknecht, Lyn ...
Wang, Ya Xing
Wareham, Nichola ...
Watkins, Hugh
Weir, David R.
Wickremasinghe, ...
Zheng, Wei
Elliott, Paul
North, Kari E.
Bouchard, Claude
Evans, Michele K ...
Gudnason, Vilmun ...
Liu, Ching-Ti
Liu, Yongmei
Psaty, Bruce M.
Ridker, Paul M.
van Dam, Rob M.
Kardia, Sharon L ...
Zhu, Xiaofeng
Rotimi, Charles ...
Mook-Kanamori, D ...
Fornage, Myriam
Kelly, Tanika N.
Fox, Ervin R.
Hayward, Carolin ...
van Duijn, Corne ...
Tai, E. Shyong
Wong, Tien Yin
Liu, Jingmin
Rotter, Jerome I ...
Gauderman, W. Ja ...
Province, Michae ...
Munroe, Patricia ...
Rice, Kenneth
Chasman, Daniel ...
Cupples, L. Adri ...
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Morrison, Alanna ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Health Sciences
and Public Health Gl ...
Articles in the publication
American Journal ...
By the university
Umeå University
Lund University
Karolinska Institutet

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