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Monoamine related f...
Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers.
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- Jönsson, Erik G (author)
- Karolinska Institutet
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- Bah Rösman, Jessica, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology
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- Melke, Jonas, 1971 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology
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Abou Jamra, Rami (author)
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Schumacher, Johannes (author)
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- Westberg, Lars, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology
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Ivo, Roland (author)
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Cichon, Sven (author)
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Propping, Peter (author)
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Nöthen, Markus M (author)
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- Eriksson, Elias, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology
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Sedvall, Göran C (author)
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(creator_code:org_t)
- 2004
- 2004
- English.
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In: BMC psychiatry. - 1471-244X. ; 4
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: Concentrations of monoamine metabolites in human cerebrospinal fluid (CSF) have been used extensively as indirect estimates of monoamine turnover in the brain. CSF monoamine metabolite concentrations are partly determined by genetic influences. METHODS: We investigated possible relationships between DNA polymorphisms in the serotonin 2C receptor (HTR2C), the serotonin 3A receptor (HTR3A), the dopamine D4 receptor (DRD4), and the dopamine beta-hydroxylase (DBH) genes and CSF concentrations of 5-hydroxyindolacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy volunteers (n = 90). RESULTS: The HTR3A 178 C/T variant was associated with 5-HIAA levels (p = 0.02). The DBH-1021 heterozygote genotype was associated with 5-HIAA (p = 0.0005) and HVA (p = 0.009) concentrations. Neither the HTR2C Cys23Ser variant, nor the DRD4 -521 C/T variant were significantly associated with any of the monoamine metabolites. CONCLUSIONS: The present results suggest that the HTR3A and DBH genes may participate in the regulation of dopamine and serotonin turnover rates in the central nervous system.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Brain
- Dopamine
- genetics
- Female
- Gene Frequency
- Genotype
- Homovanillic Acid
- cerebrospinal fluid
- metabolism
- Humans
- Hydroxyindoleacetic Acid
- cerebrospinal fluid
- metabolism
- Longitudinal Studies
- Male
- Methoxyhydroxyphenylglycol
- cerebrospinal fluid
- metabolism
- Middle Aged
- Polymorphism
- Genetic
- Psychiatric Status Rating Scales
- Receptor
- Serotonin
- 5-HT2C
- genetics
- Receptors
- Dopamine D2
- genetics
- Receptors
- Dopamine D4
- Receptors
- Serotonin
- 5-HT3
- genetics
- Serotonin
- metabolism
- Variation (Genetics)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Jönsson, Erik G
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Bah Rösman, Jess ...
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Melke, Jonas, 19 ...
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Abou Jamra, Rami
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Schumacher, Joha ...
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Westberg, Lars, ...
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show more...
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Ivo, Roland
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Cichon, Sven
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Propping, Peter
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Nöthen, Markus M
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Eriksson, Elias, ...
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Sedvall, Göran C
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
- Articles in the publication
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BMC psychiatry
- By the university
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University of Gothenburg
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Karolinska Institutet