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Pregnancy induces p...
Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes
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- Espes, Daniel, 1985- (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Transplantation och regenerativ medicin,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Sweden; Uppsala Univ, Sweden
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- Magnusson, Louise, 1992- (författare)
- Linköpings universitet,Uppsala universitet,Institutionen för medicinska vetenskaper,Linköping University, Department of Biomedical and Clinical Sciences, Division of Children and Women health,Per-Ola Carlsson,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Uppsala Univ, Sweden
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- Caballero-Corbalán, José (författare)
- Uppsala universitet,Transplantation och regenerativ medicin,Uppsala Univ, Sweden
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- Schwarcz, Erik (författare)
- Örebro University Hospital, Department of Internal Medicine,Orebro Univ Hosp, Sweden
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- Casas, Rosaura (författare)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten
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- Carlsson, Per-Ola (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Transplantation och regenerativ medicin,Uppsala Univ, Sweden; Uppsala Univ, Sweden
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(creator_code:org_t)
- 2022-11-08
- 2022
- Engelska.
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Ingår i: BMJ Open Diabetes Research & Care. - : BMJ Publishing Group Ltd. - 2052-4897. ; 10:6
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Introduction: Pregnancy entails both pancreatic adaptations with increasing beta-cell mass and immunological alterations in healthy women. In this study, we have examined the effects of pregnancy on beta-cell function and immunological processes in long-standing type 1 diabetes (L-T1D).Research design and methods: Fasting and stimulated C-peptide were measured after an oral glucose tolerance test in pregnant women with L-T1D (n=17) during the first trimester, third trimester, and 5-8 weeks post partum. Two 92-plex Olink panels were used to measure proteins in plasma. Non-pregnant women with L-T1D (n=30) were included for comparison.Results: Fasting C-peptide was detected to a higher degree in women with L-T1D during gestation and after parturition (first trimester: 64.7%, third trimester: 76.5%, and post partum: 64.7% vs 26.7% in non-pregnant women). Also, total insulin secretion and peak C-peptide increased during pregnancy. The plasma protein levels in pregnant women with L-T1D was dynamic, but few analytes were functionally related. Specifically, peripheral levels of prolactin (PRL), prokineticin (PROK)-1, and glucagon (GCG) were elevated during gestation whereas levels of proteins related to leukocyte migration (CCL11), T cell activation (CD28), and antigen presentation (such as CD83) were reduced.Conclusions: In summary, we have found that some C-peptide secretion, that is, an indirect measurement of endogenous insulin production, is regained in women with L-T1D during pregnancy, which might be attributed to elevated peripheral levels of PRL, PROK-1, or GCG.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Type 1 diabetes
- pregnancy
- β-cell function
- prolactin
- prokineticin-1
- glucagon
- immunomodulation
- Endocrinology and Diabetology
- Endokrinologi och Diabetologi
- Obstetrik och gynekologi
- Obstetrics and Gynaecology
- Biology with specialization in Molecular Immunology
- Biologi med inriktning mot molekylär immunologi
- Klinisk immunologi
- Clinical Immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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