A Large-Scale Genome-Wide Gene-Gene Interaction Study of Lung Cancer Susceptibility in Europeans With a Trans-Ethnic Validation in Asians

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A Large-Scale Genome-Wide Gene-Gene Interaction Study of Lung Cancer Susceptibility in Europeans With a Trans-Ethnic Validation in Asians

Zhang, Ruyang (författare): Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Massachusetts, Boston; China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, China

Shen, Sipeng (författare): Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Massachusetts, Boston; China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, China; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China

Wei, Yongyue (författare): Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Massachusetts, Boston; China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, China

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Zhu, Ying (författare): Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China

Li, Yi (författare): Department of Biostatistics, University of Michigan, MI, Ann Arbor, United States

Chen, Jiajin (författare): Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China

Guan, Jinxing (författare): Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China

Pan, Zoucheng (författare): Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China

Wang, Yuzhuo (författare): Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China

Zhu, Meng (författare): Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China

Xie, Junxing (författare): Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China

Xiao, Xiangjun (författare): The Institute for Clinical and Translational Research, Department of Medicine, Baylor College of Medicine, Texas, Houston

Zhu, Dakai (författare): The Institute for Clinical and Translational Research, Department of Medicine, Baylor College of Medicine, Texas, Houston

Li, Yafang (författare): The Institute for Clinical and Translational Research, Department of Medicine, Baylor College of Medicine, Texas, Houston

Albanes, Demetrios (författare): Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Maryland, Bethesda

Landi, Maria Teresa (författare): Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Maryland, Bethesda

Caporaso, Neil E. (författare): Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Maryland, Bethesda

Lam, Stephen (författare): Department of Medicine, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada

Tardon, Adonina (författare): Faculty of Medicine, University of Oviedo and CIBERESP, Oviedo, Spain

Chen, Chu (författare): Department of Epidemiology, University of Washington School of Public Health, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States

Bojesen, Stig E. (författare): Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark

Johansson, Mattias (författare): Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France

Risch, Angela (författare): Department of Biosciences and Cancer Cluster Salzburg, University of Salzburg, Salzburg, Austria

Bickeböller, Heike (författare): Department of Genetic Epidemiology, University Medical Center, Georg August University Göttingen, Göttingen, Germany

Wichmann, H-Erich (författare): Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians University, Munich, Germany

Rennert, Gadi (författare): Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Carmel, Israel

Arnold, Susanne (författare): Markey Cancer Center, University of Kentucky, Kentucky, Lexington

Brennan, Paul (författare): Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France

McKay, James D. (författare): Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France

Field, John K. (författare): Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom

Shete, Sanjay S. (författare): Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Texas, Houston

Le Marchand, Loic (författare): Epidemiology Program, University of Hawaii Cancer Center, HI, Honolulu, United States

Liu, Geoffrey (författare): Princess Margaret Cancer Centre, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada

Andrew, Angeline S. (författare): Department of Epidemiology, Department of Community and Family Medicine, Dartmouth Geisel School of Medicine, New Hampshire, Hanover

Kiemeney, Lambertus A. (författare): Department for Health Evidence, Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands

Zienolddiny-Narui, Shan (författare): National Institute of Occupational Health, Oslo, Norway

Behndig, Annelie F., 1963- (författare): Umeå universitet,Avdelningen för medicin

Johansson, Mikael (författare): Umeå universitet,Onkologi

Cox, Angela (författare): Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, United Kingdom

Lazarus, Philip (författare): Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, WA, Spokane, United States

Schabath, Matthew B. (författare): Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Florida, Tampa

Aldrich, Melinda C. (författare): Department of Thoracic Surgery and Division of Epidemiology, Vanderbilt University Medical Center, TN, Nashville, United States

Dai, Juncheng (författare): Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China

Ma, Hongxia (författare): Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China

Zhao, Yang (författare): Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China

Hu, Zhibin (författare): China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, China; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China

Hung, Rayjean J. (författare): Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Dalla Lana School of Public Health, University of Toronto, ON, Toronto, Canada

Amos, Christopher I. (författare): The Institute for Clinical and Translational Research, Department of Medicine, Baylor College of Medicine, Texas, Houston

Shen, Hongbing (författare): China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, China; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China

Chen, Feng (författare): Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China; China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China

Christiani, David C. (författare): Department of Environmental Health, Harvard T. H. Chan School of Public Health, Massachusetts, Boston; Pulmonary and Critical Care Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Massachusetts, Boston

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Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Environmental Health, Harvard T H. Chan School of Public Health, Massachusetts, Boston; China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, China Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Massachusetts, Boston; China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, China; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China (creator_code:org_t)

Elsevier, 2022
2022
Engelska.
Ingår i: Journal of Thoracic Oncology. - : Elsevier. - 1556-0864 .- 1556-1380. ; 17:8, s. 974-990

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

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Introduction: Although genome-wide association studies have been conducted to investigate genetic variation of lung tumorigenesis, little is known about gene-gene (G × G) interactions that may influence the risk of non-small cell lung cancer (NSCLC).Methods: Leveraging a total of 445,221 European-descent participants from the International Lung Cancer Consortium OncoArray project, Transdisciplinary Research in Cancer of the Lung and UK Biobank, we performed a large-scale genome-wide G × G interaction study on European NSCLC risk by a series of analyses. First, we used BiForce to evaluate and rank more than 58 billion G × G interactions from 340,958 single-nucleotide polymorphisms (SNPs). Then, the top interactions were further tested by demographically adjusted logistic regression models. Finally, we used the selected interactions to build lung cancer screening models of NSCLC, separately, for never and ever smokers.Results: With the Bonferroni correction, we identified eight statistically significant pairs of SNPs, which predominantly appeared in the 6p21.32 and 5p15.33 regions (e.g., rs521828C6orf10 and rs204999PRRT1, ORinteraction = 1.17, p = 6.57 × 10−13; rs3135369BTNL2 and rs2858859HLA-DQA1, ORinteraction = 1.17, p = 2.43 × 10−13; rs2858859HLA-DQA1 and rs9275572HLA-DQA2, ORinteraction = 1.15, p = 2.84 × 10−13; rs2853668TERT and rs62329694CLPTM1L, ORinteraction = 0.73, p = 2.70 × 10−13). Notably, even with much genetic heterogeneity across ethnicities, three pairs of SNPs in the 6p21.32 region identified from the European-ancestry population remained significant among an Asian population from the Nanjing Medical University Global Screening Array project (rs521828C6orf10 and rs204999PRRT1, ORinteraction = 1.13, p = 0.008; rs3135369BTNL2 and rs2858859HLA-DQA1, ORinteraction = 1.11, p = 5.23 × 10−4; rs3135369BTNL2 and rs9271300HLA-DQA1, ORinteraction = 0.89, p = 0.006). The interaction-empowered polygenetic risk score that integrated classical polygenetic risk score and G × G information score was remarkable in lung cancer risk stratification.Conclusions: Important G × G interactions were identified and enriched in the 5p15.33 and 6p21.32 regions, which may enhance lung cancer screening models.

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Av författaren/redakt...: Zhang, Ruyang; Shen, Sipeng; Wei, Yongyue; Zhu, Ying; Li, Yi; Chen, Jiajin; visa fler...; Guan, Jinxing; Pan, Zoucheng; Wang, Yuzhuo; Zhu, Meng; Xie, Junxing; Xiao, Xiangjun; Zhu, Dakai; Li, Yafang; Albanes, Demetri ...; Landi, Maria Ter ...; Caporaso, Neil E ...; Lam, Stephen; Tardon, Adonina; Chen, Chu; Bojesen, Stig E.; Johansson, Matti ...; Risch, Angela; Bickeböller, Hei ...; Wichmann, H-Eric ...; Rennert, Gadi; Arnold, Susanne; Brennan, Paul; McKay, James D.; Field, John K.; Shete, Sanjay S.; Le Marchand, Loi ...; Liu, Geoffrey; Andrew, Angeline ...; Kiemeney, Lamber ...; Zienolddiny-Naru ...; Behndig, Annelie ...; Johansson, Mikae ...; Cox, Angela; Lazarus, Philip; Schabath, Matthe ...; Aldrich, Melinda ...; Dai, Juncheng; Ma, Hongxia; Zhao, Yang; Hu, Zhibin; Hung, Rayjean J.; Amos, Christophe ...; Shen, Hongbing; Chen, Feng; Christiani, Davi ...; visa färre...

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A Large-Scale Genome-Wide Gene-Gene Interaction Study of Lung Cancer Susceptibility in Europeans With a Trans-Ethnic Validation in Asians

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